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- W3204800145 abstract "Leishmania parasites, endemic in (sub)tropical regions, cause a neglected tropical disease affecting ∼12 million cases worldwide. The spectrum of pathologies ranges from cutaneous leishmaniasis to progressive fatal visceral disease. Both in humans and mice, healing is associated with successful development of IFN-γ‒producing T helper type (Th)1/Tc1 cells, whereas Th2-, Th17-, and regulatory T-cell‒predominant responses are associated with progression and/or nonhealing lesions ( Kautz-Neu et al., 2011 Kautz-Neu K. Noordegraaf M. Dinges S. Bennett C.L. John D. Clausen B.E. et al. Langerhans cells are negative regulators of the anti-Leishmania response. J Exp Med. 2011; 208: 885-891 Google Scholar ; Sacks and Noben-Trauth, 2002 Sacks D. Noben-Trauth N. The immunology of susceptibility and resistance to Leishmania major in mice. Nat Rev Immunol. 2002; 2: 845-858 Google Scholar ). After transmission, Leishmania major primarily resides in skin-resident macrophages. Lesion infiltrating IFN-γ+ T cells activate macrophages to eliminate parasites through nitric oxide ( Sacks and Noben-Trauth, 2002 Sacks D. Noben-Trauth N. The immunology of susceptibility and resistance to Leishmania major in mice. Nat Rev Immunol. 2002; 2: 845-858 Google Scholar ). In contrast to the silent invasion of macrophages, parasite internalization by dendritic cells (DCs) triggers DC activation ( Woelbing et al., 2006 Woelbing F. Susanna L.K. Moelle K. Belkaid Y. Sunderkoetter C. Verbeek S. et al. Uptake of Leishmania major by dendritic cells is mediated by Fcgamma receptors and facilitates acquisition of protective immunity. J Exp Med. 2006; 203: 177-188 Google Scholar ), and infected DCs are considered to induce protection by IL-12 ( von Stebut et al., 1998 von Stebut E. Belkaid Y. Jakob T. Sacks D.L. Udey M.C. Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: implications for the initiation of anti-Leishmania immunity. J Exp Med. 1998; 188: 1547-1552 Google Scholar ) and by priming T cells against L. major antigens. These early events after parasite inoculation are critical for disease outcome." @default.
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- W3204800145 date "2022-04-01" @default.
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- W3204800145 title "Exclusive Expression of MyD88 on Dendritic Cells Is Sufficient to Induce Protection against Experimental Leishmaniasis" @default.
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- W3204800145 doi "https://doi.org/10.1016/j.jid.2021.07.184" @default.
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