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- W3204804300 abstract "Summary Thalamo-cortical networks are central to seizures, yet it’s unclear how these circuits initiate the seizures. Here, we test the hypothesis that a facial region of the thalamus, the VPM, is a source of convulsive, tonic-clonic seizures. We devised an in vivo optogenetic mouse model to elicit tonic-clonic seizures by driving convergent input to the VPM. With viral tracing, we show dense cerebellar and cerebral cortical afferent input to the VPM. Lidocaine microinfusions into the cerebellar nuclei selectively block seizure initiation. We perform single-unit electrophysiology recordings during awake, convulsive seizures to define the local activity of thalamic neurons before, during, and after seizure onset. We find highly dynamic activity with biphasic properties, raising the possibility that heterogenous activity patterns promote seizures. These data reveal the VPM as a source of tonic-clonic seizures, with cerebellar input providing the predominant signals." @default.
- W3204804300 created "2021-10-11" @default.
- W3204804300 creator A5016253930 @default.
- W3204804300 creator A5016499365 @default.
- W3204804300 creator A5018073672 @default.
- W3204804300 creator A5025289533 @default.
- W3204804300 creator A5028598270 @default.
- W3204804300 creator A5047948555 @default.
- W3204804300 creator A5065038541 @default.
- W3204804300 creator A5079586132 @default.
- W3204804300 date "2021-10-04" @default.
- W3204804300 modified "2023-10-10" @default.
- W3204804300 title "The cerebellum initiates severe tonic-clonic seizures by altering neuronal activity in the ventral posteromedial nucleus (VPM) of the thalamus" @default.
- W3204804300 cites W1488963943 @default.
- W3204804300 cites W1536140107 @default.
- W3204804300 cites W1540527416 @default.
- W3204804300 cites W1561828919 @default.
- W3204804300 cites W1571175443 @default.
- W3204804300 cites W1573130913 @default.
- W3204804300 cites W1584032916 @default.
- W3204804300 cites W1595628840 @default.
- W3204804300 cites W1597791432 @default.
- W3204804300 cites W1852864209 @default.
- W3204804300 cites W1875008998 @default.
- W3204804300 cites W1885768053 @default.
- W3204804300 cites W1886118302 @default.
- W3204804300 cites W1923144898 @default.
- W3204804300 cites W1925702297 @default.
- W3204804300 cites W1968028223 @default.
- W3204804300 cites W1970604942 @default.
- W3204804300 cites W1970716388 @default.
- W3204804300 cites W1972536156 @default.
- W3204804300 cites W1974622727 @default.
- W3204804300 cites W1974809694 @default.
- W3204804300 cites W1974913796 @default.
- W3204804300 cites W1976004204 @default.
- W3204804300 cites W1983669692 @default.
- W3204804300 cites W1985383576 @default.
- W3204804300 cites W1987332330 @default.
- W3204804300 cites W1988904564 @default.
- W3204804300 cites W1991097570 @default.
- W3204804300 cites W1991499234 @default.
- W3204804300 cites W1994308963 @default.
- W3204804300 cites W1994404120 @default.
- W3204804300 cites W1998182517 @default.
- W3204804300 cites W2000057974 @default.
- W3204804300 cites W2001108771 @default.
- W3204804300 cites W2002538792 @default.
- W3204804300 cites W2004017387 @default.
- W3204804300 cites W2005078450 @default.
- W3204804300 cites W2013931634 @default.
- W3204804300 cites W2014384074 @default.
- W3204804300 cites W2014721375 @default.
- W3204804300 cites W2015041423 @default.
- W3204804300 cites W2016033291 @default.
- W3204804300 cites W2016815767 @default.
- W3204804300 cites W2017398416 @default.
- W3204804300 cites W2017400430 @default.
- W3204804300 cites W2017500569 @default.
- W3204804300 cites W2017728569 @default.
- W3204804300 cites W2020317154 @default.
- W3204804300 cites W2021661569 @default.
- W3204804300 cites W2027794117 @default.
- W3204804300 cites W2027853280 @default.
- W3204804300 cites W2034737047 @default.
- W3204804300 cites W2038017090 @default.
- W3204804300 cites W2041093905 @default.
- W3204804300 cites W2041154430 @default.
- W3204804300 cites W2041180517 @default.
- W3204804300 cites W2042729163 @default.
- W3204804300 cites W2046463158 @default.
- W3204804300 cites W2046846097 @default.
- W3204804300 cites W2051703153 @default.
- W3204804300 cites W2052990681 @default.
- W3204804300 cites W2053785929 @default.
- W3204804300 cites W2054926428 @default.
- W3204804300 cites W2057342244 @default.
- W3204804300 cites W2058511752 @default.
- W3204804300 cites W2058627363 @default.
- W3204804300 cites W2058979471 @default.
- W3204804300 cites W2062693892 @default.
- W3204804300 cites W2063199558 @default.
- W3204804300 cites W2063454012 @default.
- W3204804300 cites W2063569651 @default.
- W3204804300 cites W20638205 @default.
- W3204804300 cites W2064139020 @default.
- W3204804300 cites W2068102319 @default.
- W3204804300 cites W2069328624 @default.
- W3204804300 cites W2074069661 @default.
- W3204804300 cites W2075385578 @default.
- W3204804300 cites W2076862449 @default.
- W3204804300 cites W2076993158 @default.
- W3204804300 cites W2077594923 @default.
- W3204804300 cites W2078361688 @default.
- W3204804300 cites W2083785141 @default.
- W3204804300 cites W2084473005 @default.
- W3204804300 cites W2089513832 @default.
- W3204804300 cites W2091071848 @default.
- W3204804300 cites W2092665614 @default.
- W3204804300 cites W2094656460 @default.