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- W3204808624 abstract "Abstract Vessel models are a first step in developing endovascular medical devices. However, these models, often made from glass or silicone, do not accurately represent the mechanical properties of human vascular tissue, limiting their use to basic training and proof‐of‐concept testing. This study outlines methods to quantify human vascular tissue mechanical properties and synthetic biomaterials for creating representative vessel models. Human vascular tissue was assessed and compared to silicone and new UV‐cured polymers (VC‐A30) using the following eight mechanical tests: compressive, shear, tensile dynamic elastic modulus, Poisson's ratio, hardness, radial force, compliance, and lubricity. Half of these testing methods were nondestructive, allowing for multiple mechanical and histological characterizations of the same human tissue sample. Histological evaluation of the cellular and extracellular matrix of the human vessels verified that the dynamic moduli and Poison's ratio tests were nondestructive. Fluid absorption by VC‐A30 showed statistically significant softening of mechanical properties, stabilizing after 4 days in phosphate‐buffered saline (PBS). Human vasculature exhibited notably similar results to VC‐A30 in five of eight mechanical tests (≤30% difference) versus two of eight for standard silicone (≤38% difference). Results show that VC‐A30 provides a new option for 3D‐printing translucent in vitro vascular models with anatomically relevant mechanical properties. These new vessel analogs may simulate patient‐specific vessel disease states, improve surgical training models, accelerate new endovascular device developments, and ultimately reduce the need for animal models." @default.
- W3204808624 created "2021-10-11" @default.
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- W3204808624 date "2021-10-06" @default.
- W3204808624 modified "2023-10-17" @default.
- W3204808624 title "Application of nondestructive mechanical characterization testing for creating in vitro vessel models with material properties similar to human neurovasculature" @default.
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- W3204808624 doi "https://doi.org/10.1002/jbm.a.37314" @default.
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