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- W3204826500 endingPage "10411" @default.
- W3204826500 startingPage "10411" @default.
- W3204826500 abstract "Neurotrophins (NTs) and their signal-transducing Trk receptors play a crucial role in the development and maintenance of specific neuronal subpopulations in nervous and sensory systems. NTs are supposed to regulate two sensory systems in fish, the inner ear and the lateral line system (LLS). The latter is one of the major mechanosensory systems in fish. Considering that annual fishes of the genus Nothobranchius, with their short life expectancy, have become a suitable model for aging studies and that the occurrence and distribution of neurotrophin Trk receptors have never been investigated in the inner ear and LLS of killifish (Nothobranchius guentheri), our study aimed to investigate the localization of neurotrophin-specific Trk receptors in mechanosensory systems of N. guentheri. For histological and immunohistochemical analysis, adult specimens of N. guentheri were processed using antibodies against Trk receptors and S100 protein. An intense immunoreaction for TrkA and TrkC was found in the sensory cells of the inner ear as well as in the hair cells of LLS. Moreover, also the neurons localized in the acoustic ganglia displayed a specific immunoreaction for all Trk receptors (TrkA, B, and C) analyzed. Taken together, our results demonstrate, for the first time, that neurotrophins and their specific receptors could play a pivotal role in the biology of the sensory cells of the inner ear and LLS of N. guentheri and might also be involved in the hair cells regeneration process in normal and aged conditions." @default.
- W3204826500 created "2021-10-11" @default.
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- W3204826500 date "2021-09-27" @default.
- W3204826500 modified "2023-10-16" @default.
- W3204826500 title "Localization of Neurotrophin Specific Trk Receptors in Mechanosensory Systems of Killifish (Nothobranchius guentheri)" @default.
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- W3204826500 doi "https://doi.org/10.3390/ijms221910411" @default.
- W3204826500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8508645" @default.
- W3204826500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34638748" @default.
- W3204826500 hasPublicationYear "2021" @default.
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