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- W3204835639 abstract "Abstract Aims Mammalian models have been instrumental in investigating adult heart function and human disease. However, electrophysiological differences with human hearts and high costs motivate the need for non-mammalian models. The zebrafish is a well-established genetic model to study cardiovascular development and function; however, analysis of cardiovascular phenotypes in adult specimens is particularly challenging as they are opaque. Methods and results Here, we optimized and combined multiple imaging techniques including echocardiography, magnetic resonance imaging, and micro-computed tomography to identify and analyse cardiovascular phenotypes in adult zebrafish. Using alk5a/tgfbr1a mutants as a case study, we observed morphological and functional cardiovascular defects that were undetected with conventional approaches. Correlation analysis of multiple parameters revealed an association between haemodynamic defects and structural alterations of the heart, as observed clinically. Conclusion We report a new, comprehensive, and sensitive platform to identify otherwise indiscernible cardiovascular phenotypes in adult zebrafish." @default.
- W3204835639 created "2021-10-11" @default.
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- W3204835639 date "2021-10-05" @default.
- W3204835639 modified "2023-10-17" @default.
- W3204835639 title "Integration of multiple imaging platforms to uncover cardiovascular defects in adult zebrafish" @default.
- W3204835639 cites W1559457086 @default.
- W3204835639 cites W1586710766 @default.
- W3204835639 cites W1597037822 @default.
- W3204835639 cites W1802842093 @default.
- W3204835639 cites W1868639450 @default.
- W3204835639 cites W195929454 @default.
- W3204835639 cites W1963577861 @default.
- W3204835639 cites W1964506754 @default.
- W3204835639 cites W1966140207 @default.
- W3204835639 cites W1970727687 @default.
- W3204835639 cites W1978760292 @default.
- W3204835639 cites W1979704028 @default.
- W3204835639 cites W1984568594 @default.
- W3204835639 cites W1987814308 @default.
- W3204835639 cites W1988204416 @default.
- W3204835639 cites W1992521055 @default.
- W3204835639 cites W2005378212 @default.
- W3204835639 cites W2007077541 @default.
- W3204835639 cites W2007294720 @default.
- W3204835639 cites W2009476579 @default.
- W3204835639 cites W201005056 @default.
- W3204835639 cites W2011268646 @default.
- W3204835639 cites W2013756638 @default.
- W3204835639 cites W2016120432 @default.
- W3204835639 cites W2025900960 @default.
- W3204835639 cites W2027378077 @default.
- W3204835639 cites W2028460986 @default.
- W3204835639 cites W2039577288 @default.
- W3204835639 cites W2042486735 @default.
- W3204835639 cites W2043699909 @default.
- W3204835639 cites W2047286882 @default.
- W3204835639 cites W2050987730 @default.
- W3204835639 cites W2051761500 @default.
- W3204835639 cites W2054351373 @default.
- W3204835639 cites W2060940665 @default.
- W3204835639 cites W2062748955 @default.
- W3204835639 cites W2067751321 @default.
- W3204835639 cites W2072890764 @default.
- W3204835639 cites W2080127892 @default.
- W3204835639 cites W2081800993 @default.
- W3204835639 cites W2093971209 @default.
- W3204835639 cites W2101218471 @default.
- W3204835639 cites W2101427309 @default.
- W3204835639 cites W2106242560 @default.
- W3204835639 cites W2110477765 @default.
- W3204835639 cites W2112779993 @default.
- W3204835639 cites W2114232003 @default.
- W3204835639 cites W2122867046 @default.
- W3204835639 cites W2124821411 @default.
- W3204835639 cites W2125070706 @default.
- W3204835639 cites W2126747203 @default.
- W3204835639 cites W2128084148 @default.
- W3204835639 cites W2128492413 @default.
- W3204835639 cites W2133306079 @default.
- W3204835639 cites W2141279088 @default.
- W3204835639 cites W2148058963 @default.
- W3204835639 cites W2148989249 @default.
- W3204835639 cites W2150627711 @default.
- W3204835639 cites W2153784828 @default.
- W3204835639 cites W2154562061 @default.
- W3204835639 cites W2170324158 @default.
- W3204835639 cites W2171905803 @default.
- W3204835639 cites W2192521069 @default.
- W3204835639 cites W2223222705 @default.
- W3204835639 cites W2232186714 @default.
- W3204835639 cites W2247019433 @default.
- W3204835639 cites W2254920228 @default.
- W3204835639 cites W2258633410 @default.
- W3204835639 cites W2261166893 @default.
- W3204835639 cites W2265858828 @default.
- W3204835639 cites W2287791542 @default.
- W3204835639 cites W2318839711 @default.
- W3204835639 cites W2324395766 @default.
- W3204835639 cites W2337015397 @default.
- W3204835639 cites W2341037699 @default.
- W3204835639 cites W2341459206 @default.
- W3204835639 cites W2444473664 @default.
- W3204835639 cites W2473620344 @default.
- W3204835639 cites W2474518089 @default.
- W3204835639 cites W2539363761 @default.
- W3204835639 cites W2554653915 @default.