Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204868158> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W3204868158 endingPage "71" @default.
- W3204868158 startingPage "65" @default.
- W3204868158 abstract "Neutralization ability of some antiviral nanobodies was computed against the receptor binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2). CoDockPP Server and COVID-19 Docking Server respectively was applied for a protein-protein molecular docking. The affinity of candidate nonobodies was investigated for blocking of RBD against the human angiotensin coverting enzyme 2 (ACE2). The neutralization ability of nonobodies was compared with natural nanobodies of Ty1, H11-H4, EY6A, H11-D4 and synthetic construct of Sb23, ybody MR17, sybody MR17-K99Y, and SR4 that experimentally was involved against the RBD of SARS-COV 2. It was seen, the 15 reported VHH was able for blocking with an estimated binding energy greater than -235.55 (kcal/mol) for Ty1 with the lowest affinity to the RBD. VHH 7A, VHH PVSP29F, Cameld VHH 9, VHH PVSS8A, VHH 12B, VHH 59H10, VHH PVSP6A, VHH 10E, VHH 17B and VHH 59H10 respectively was proposed for neutralization of RBD while the two last VHH are more confidence due to the greater values of affinity against -342.56 (kcal/mol) for SR4. The energy maps of ACE2, VHH 17B and VHH 59H10 was identified that hydrogen donor, steric, hydrogen acceptor and electrostatic interactions respectively were significant for blocking RBD of SARS-COV 2. This study conform structural insight for neutralization of RBD spike glycoprotein of SARS-COV 2 by nanobodies and suggest VHH that may serve as useful therapeutics during the pandemic." @default.
- W3204868158 created "2021-10-11" @default.
- W3204868158 creator A5012420457 @default.
- W3204868158 creator A5067084350 @default.
- W3204868158 date "2021-06-01" @default.
- W3204868158 modified "2023-09-28" @default.
- W3204868158 title "Molecular docking study and mapping the binding site of some antiviral nanobodies against receptor binding domain (RBD) of SARS-COV 2" @default.
- W3204868158 doi "https://doi.org/10.22036/ncr.2021.01.006" @default.
- W3204868158 hasPublicationYear "2021" @default.
- W3204868158 type Work @default.
- W3204868158 sameAs 3204868158 @default.
- W3204868158 citedByCount "0" @default.
- W3204868158 crossrefType "journal-article" @default.
- W3204868158 hasAuthorship W3204868158A5012420457 @default.
- W3204868158 hasAuthorship W3204868158A5067084350 @default.
- W3204868158 hasConcept C107824862 @default.
- W3204868158 hasConcept C14086860 @default.
- W3204868158 hasConcept C142724271 @default.
- W3204868158 hasConcept C153911025 @default.
- W3204868158 hasConcept C159047783 @default.
- W3204868158 hasConcept C159110408 @default.
- W3204868158 hasConcept C185592680 @default.
- W3204868158 hasConcept C2522874641 @default.
- W3204868158 hasConcept C2779134260 @default.
- W3204868158 hasConcept C3007834351 @default.
- W3204868158 hasConcept C3008058167 @default.
- W3204868158 hasConcept C41685203 @default.
- W3204868158 hasConcept C51639874 @default.
- W3204868158 hasConcept C524204448 @default.
- W3204868158 hasConcept C55493867 @default.
- W3204868158 hasConcept C71924100 @default.
- W3204868158 hasConcept C86803240 @default.
- W3204868158 hasConceptScore W3204868158C107824862 @default.
- W3204868158 hasConceptScore W3204868158C14086860 @default.
- W3204868158 hasConceptScore W3204868158C142724271 @default.
- W3204868158 hasConceptScore W3204868158C153911025 @default.
- W3204868158 hasConceptScore W3204868158C159047783 @default.
- W3204868158 hasConceptScore W3204868158C159110408 @default.
- W3204868158 hasConceptScore W3204868158C185592680 @default.
- W3204868158 hasConceptScore W3204868158C2522874641 @default.
- W3204868158 hasConceptScore W3204868158C2779134260 @default.
- W3204868158 hasConceptScore W3204868158C3007834351 @default.
- W3204868158 hasConceptScore W3204868158C3008058167 @default.
- W3204868158 hasConceptScore W3204868158C41685203 @default.
- W3204868158 hasConceptScore W3204868158C51639874 @default.
- W3204868158 hasConceptScore W3204868158C524204448 @default.
- W3204868158 hasConceptScore W3204868158C55493867 @default.
- W3204868158 hasConceptScore W3204868158C71924100 @default.
- W3204868158 hasConceptScore W3204868158C86803240 @default.
- W3204868158 hasIssue "1" @default.
- W3204868158 hasLocation W32048681581 @default.
- W3204868158 hasOpenAccess W3204868158 @default.
- W3204868158 hasPrimaryLocation W32048681581 @default.
- W3204868158 hasRelatedWork W2013424931 @default.
- W3204868158 hasRelatedWork W2035391106 @default.
- W3204868158 hasRelatedWork W2168127380 @default.
- W3204868158 hasRelatedWork W2742103419 @default.
- W3204868158 hasRelatedWork W2915219798 @default.
- W3204868158 hasRelatedWork W2949858554 @default.
- W3204868158 hasRelatedWork W3014931477 @default.
- W3204868158 hasRelatedWork W3016198677 @default.
- W3204868158 hasRelatedWork W3016501928 @default.
- W3204868158 hasRelatedWork W3038701172 @default.
- W3204868158 hasRelatedWork W3046019655 @default.
- W3204868158 hasRelatedWork W3091450729 @default.
- W3204868158 hasRelatedWork W3099641350 @default.
- W3204868158 hasRelatedWork W3124140604 @default.
- W3204868158 hasRelatedWork W3125019546 @default.
- W3204868158 hasRelatedWork W3161124376 @default.
- W3204868158 hasRelatedWork W3200077157 @default.
- W3204868158 hasRelatedWork W3200349451 @default.
- W3204868158 hasRelatedWork W3202799865 @default.
- W3204868158 hasRelatedWork W3214036783 @default.
- W3204868158 hasVolume "6" @default.
- W3204868158 isParatext "false" @default.
- W3204868158 isRetracted "false" @default.
- W3204868158 magId "3204868158" @default.
- W3204868158 workType "article" @default.