FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204885078> ?p ?o ?g. }

• W3204885078 abstract "Background: Amantadine has been proposed to inhibit E-channel conductance in reconstituted lipid bilayers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We aimed to study whether patients on amantadine have altered risks of contracting COVID-19 infection. Methods: We conducted a hospital-based, observational, retrospective cohort study using data for patients on amantadine supported by data given by the patients through an online questionnaire. We included registered amantadine users in our hospital for 6 months or more on March 1, 2020, and non-amantadine users to act as the control group. We used forced entry, multiple logistic regression models to estimate adjusted ORs for amantadine adjusting for the confounders. Findings: Between September 1, 2019, and March 1, 2020, 212 patients with Parkinson's disease (PD) or multiple sclerosis (MS) received greater than one equal to two prescriptions of amantadine. We selected a random sample of diagnoses which matched 424 patients of non-amantadine users (1:2) as a control group (424 patients). Between March 1, 2020, and March 1, 2021, 256 patients responded to our online questionnaire, 87 patients were on amantadine (group I), and 169 patients were not (control group, group II). COVID-19 disease infection proved to be 5.7 and 11.8% in group I and II patients, respectively. Increased odds of COVID-19 in multivariable-adjusted models were associated with old age and history of contact with COVID cases. Amantadine was associated with a significantly reduced risk of COVID-19 disease infection (adjusted OR 0.256, 95% CI 0.074-0.888). Interpretation: Amantadine is associated with a reduced risk of COVID-19 infection after adjusting for a broad range of variables. History of contact with COVID cases and old age are risk factors for COVID-19 infection. Therefore, we recommended randomized clinical trials investigating amantadine use for the prevention of COVID-19." @default.
• W3204885078 created "2021-10-11" @default.
• W3204885078 creator A5015301748 @default.
• W3204885078 creator A5017841123 @default.
• W3204885078 creator A5019022858 @default.
• W3204885078 creator A5019938629 @default.
• W3204885078 creator A5024966646 @default.
• W3204885078 creator A5044265911 @default.
• W3204885078 date "2021-10-07" @default.
• W3204885078 modified "2023-09-30" @default.
• W3204885078 title "Effect of Pre-exposure Use of Amantadine on COVID-19 Infection: A Hospital-Based Cohort Study in Patients With Parkinson's Disease or Multiple Sclerosis" @default.
• W3204885078 cites W1218702023 @default.
• W3204885078 cites W1999592443 @default.
• W3204885078 cites W2031636396 @default.
• W3204885078 cites W2036385867 @default.
• W3204885078 cites W2126572359 @default.
• W3204885078 cites W2270371264 @default.
• W3204885078 cites W2397464061 @default.
• W3204885078 cites W2782638015 @default.
• W3204885078 cites W2792345410 @default.
• W3204885078 cites W3011896036 @default.
• W3204885078 cites W3014200959 @default.
• W3204885078 cites W3019078988 @default.
• W3204885078 cites W3019860502 @default.
• W3204885078 cites W3026398710 @default.
• W3204885078 cites W3030881596 @default.
• W3204885078 cites W3034823740 @default.
• W3204885078 cites W3087467629 @default.
• W3204885078 cites W3091843962 @default.
• W3204885078 cites W3110852579 @default.
• W3204885078 cites W3127069434 @default.
• W3204885078 doi "https://doi.org/10.3389/fneur.2021.704186" @default.
• W3204885078 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8529185" @default.
• W3204885078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34690911" @default.
• W3204885078 hasPublicationYear "2021" @default.
• W3204885078 type Work @default.
• W3204885078 sameAs 3204885078 @default.
• W3204885078 citedByCount "13" @default.
• W3204885078 countsByYear W32048850782021 @default.
• W3204885078 countsByYear W32048850782022 @default.
• W3204885078 countsByYear W32048850782023 @default.
• W3204885078 crossrefType "journal-article" @default.
• W3204885078 hasAuthorship W3204885078A5015301748 @default.
• W3204885078 hasAuthorship W3204885078A5017841123 @default.
• W3204885078 hasAuthorship W3204885078A5019022858 @default.
• W3204885078 hasAuthorship W3204885078A5019938629 @default.
• W3204885078 hasAuthorship W3204885078A5024966646 @default.
• W3204885078 hasAuthorship W3204885078A5044265911 @default.
• W3204885078 hasBestOaLocation W32048850781 @default.
• W3204885078 hasConcept C126322002 @default.
• W3204885078 hasConcept C146304588 @default.
• W3204885078 hasConcept C151956035 @default.
• W3204885078 hasConcept C156957248 @default.
• W3204885078 hasConcept C159047783 @default.
• W3204885078 hasConcept C167135981 @default.
• W3204885078 hasConcept C201903717 @default.
• W3204885078 hasConcept C2777374534 @default.
• W3204885078 hasConcept C2779134260 @default.
• W3204885078 hasConcept C71924100 @default.
• W3204885078 hasConcept C72563966 @default.
• W3204885078 hasConcept C77350462 @default.
• W3204885078 hasConceptScore W3204885078C126322002 @default.
• W3204885078 hasConceptScore W3204885078C146304588 @default.
• W3204885078 hasConceptScore W3204885078C151956035 @default.
• W3204885078 hasConceptScore W3204885078C156957248 @default.
• W3204885078 hasConceptScore W3204885078C159047783 @default.
• W3204885078 hasConceptScore W3204885078C167135981 @default.
• W3204885078 hasConceptScore W3204885078C201903717 @default.
• W3204885078 hasConceptScore W3204885078C2777374534 @default.
• W3204885078 hasConceptScore W3204885078C2779134260 @default.
• W3204885078 hasConceptScore W3204885078C71924100 @default.
• W3204885078 hasConceptScore W3204885078C72563966 @default.
• W3204885078 hasConceptScore W3204885078C77350462 @default.
• W3204885078 hasLocation W32048850781 @default.
• W3204885078 hasLocation W32048850782 @default.
• W3204885078 hasLocation W32048850783 @default.
• W3204885078 hasLocation W32048850784 @default.
• W3204885078 hasOpenAccess W3204885078 @default.
• W3204885078 hasPrimaryLocation W32048850781 @default.
• W3204885078 hasRelatedWork W1978203409 @default.
• W3204885078 hasRelatedWork W1993555144 @default.
• W3204885078 hasRelatedWork W2164301666 @default.
• W3204885078 hasRelatedWork W2414098320 @default.
• W3204885078 hasRelatedWork W2519069507 @default.
• W3204885078 hasRelatedWork W2782964653 @default.
• W3204885078 hasRelatedWork W3152215807 @default.
• W3204885078 hasRelatedWork W3206855180 @default.
• W3204885078 hasRelatedWork W4220662621 @default.
• W3204885078 hasRelatedWork W4254545923 @default.
• W3204885078 hasVolume "12" @default.
• W3204885078 isParatext "false" @default.
• W3204885078 isRetracted "false" @default.
• W3204885078 magId "3204885078" @default.
• W3204885078 workType "article" @default.