Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204902321> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W3204902321 abstract "Abstract Dynamic contacts are formed between endoplasmic reticulum (ER) and mitochondria that enable the exchange of calcium and phospholipids. Disturbed contacts between ER and mitochondria impair mitochondrial dynamics and are a molecular hallmark of Parkinson’s disease. Cystein-rich with EGF-like domain (Creld) are ER-proteins associated with atrioventricular septal defects, but human CRELD1 is also a poorly characterized risk gene for Parkinson’s disease. Here we show that Creld is required for ER-mitochondria communication. Loss of Creld leads to mitochondrial hyperfusion and reduced ROS signaling in Drosophila melanogaster, Xenopus tropicalis and human cells. We found that reduced respiratory complex I activity lowers hydrogen peroxide levels, which disturbs neuronal activity and leads to impaired locomotion in Creld mutants. Our study presents a new paradigm of neuron dysfunction as a result of impaired ER-mitochondria communication and a new model for Parkinson’s disease." @default.
- W3204902321 created "2021-10-11" @default.
- W3204902321 creator A5005291290 @default.
- W3204902321 creator A5008190985 @default.
- W3204902321 creator A5009687756 @default.
- W3204902321 creator A5011998711 @default.
- W3204902321 creator A5012796183 @default.
- W3204902321 creator A5017158319 @default.
- W3204902321 creator A5026490427 @default.
- W3204902321 creator A5051144118 @default.
- W3204902321 creator A5051588560 @default.
- W3204902321 creator A5052320996 @default.
- W3204902321 creator A5067302375 @default.
- W3204902321 creator A5078340433 @default.
- W3204902321 creator A5087922972 @default.
- W3204902321 date "2021-09-24" @default.
- W3204902321 modified "2023-09-26" @default.
- W3204902321 title "The ER protein Creld regulates ER-mitochondria contact dynamics and respiratory complex 1 activity" @default.
- W3204902321 cites W1968909025 @default.
- W3204902321 cites W1994648165 @default.
- W3204902321 cites W2004112725 @default.
- W3204902321 cites W2006963424 @default.
- W3204902321 cites W2018211893 @default.
- W3204902321 cites W2338757051 @default.
- W3204902321 cites W2766056404 @default.
- W3204902321 cites W2768013550 @default.
- W3204902321 cites W2794137713 @default.
- W3204902321 cites W2891311921 @default.
- W3204902321 cites W2896422558 @default.
- W3204902321 cites W3105272973 @default.
- W3204902321 cites W3151553656 @default.
- W3204902321 doi "https://doi.org/10.21203/rs.3.rs-911428/v1" @default.
- W3204902321 hasPublicationYear "2021" @default.
- W3204902321 type Work @default.
- W3204902321 sameAs 3204902321 @default.
- W3204902321 citedByCount "1" @default.
- W3204902321 countsByYear W32049023212022 @default.
- W3204902321 crossrefType "posted-content" @default.
- W3204902321 hasAuthorship W3204902321A5005291290 @default.
- W3204902321 hasAuthorship W3204902321A5008190985 @default.
- W3204902321 hasAuthorship W3204902321A5009687756 @default.
- W3204902321 hasAuthorship W3204902321A5011998711 @default.
- W3204902321 hasAuthorship W3204902321A5012796183 @default.
- W3204902321 hasAuthorship W3204902321A5017158319 @default.
- W3204902321 hasAuthorship W3204902321A5026490427 @default.
- W3204902321 hasAuthorship W3204902321A5051144118 @default.
- W3204902321 hasAuthorship W3204902321A5051588560 @default.
- W3204902321 hasAuthorship W3204902321A5052320996 @default.
- W3204902321 hasAuthorship W3204902321A5067302375 @default.
- W3204902321 hasAuthorship W3204902321A5078340433 @default.
- W3204902321 hasAuthorship W3204902321A5087922972 @default.
- W3204902321 hasBestOaLocation W32049023211 @default.
- W3204902321 hasConcept C104317684 @default.
- W3204902321 hasConcept C126322002 @default.
- W3204902321 hasConcept C139447449 @default.
- W3204902321 hasConcept C158617107 @default.
- W3204902321 hasConcept C2779134260 @default.
- W3204902321 hasConcept C2779535977 @default.
- W3204902321 hasConcept C2779734285 @default.
- W3204902321 hasConcept C2780104201 @default.
- W3204902321 hasConcept C28859421 @default.
- W3204902321 hasConcept C55493867 @default.
- W3204902321 hasConcept C57600042 @default.
- W3204902321 hasConcept C71924100 @default.
- W3204902321 hasConcept C86803240 @default.
- W3204902321 hasConcept C95444343 @default.
- W3204902321 hasConceptScore W3204902321C104317684 @default.
- W3204902321 hasConceptScore W3204902321C126322002 @default.
- W3204902321 hasConceptScore W3204902321C139447449 @default.
- W3204902321 hasConceptScore W3204902321C158617107 @default.
- W3204902321 hasConceptScore W3204902321C2779134260 @default.
- W3204902321 hasConceptScore W3204902321C2779535977 @default.
- W3204902321 hasConceptScore W3204902321C2779734285 @default.
- W3204902321 hasConceptScore W3204902321C2780104201 @default.
- W3204902321 hasConceptScore W3204902321C28859421 @default.
- W3204902321 hasConceptScore W3204902321C55493867 @default.
- W3204902321 hasConceptScore W3204902321C57600042 @default.
- W3204902321 hasConceptScore W3204902321C71924100 @default.
- W3204902321 hasConceptScore W3204902321C86803240 @default.
- W3204902321 hasConceptScore W3204902321C95444343 @default.
- W3204902321 hasLocation W32049023211 @default.
- W3204902321 hasOpenAccess W3204902321 @default.
- W3204902321 hasPrimaryLocation W32049023211 @default.
- W3204902321 hasRelatedWork W1994289493 @default.
- W3204902321 hasRelatedWork W1996952569 @default.
- W3204902321 hasRelatedWork W2127356527 @default.
- W3204902321 hasRelatedWork W2151417687 @default.
- W3204902321 hasRelatedWork W2884569230 @default.
- W3204902321 hasRelatedWork W2946174637 @default.
- W3204902321 hasRelatedWork W3034386412 @default.
- W3204902321 hasRelatedWork W3120897771 @default.
- W3204902321 hasRelatedWork W3138176027 @default.
- W3204902321 hasRelatedWork W3215296738 @default.
- W3204902321 isParatext "false" @default.
- W3204902321 isRetracted "false" @default.
- W3204902321 magId "3204902321" @default.
- W3204902321 workType "article" @default.