Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204903367> ?p ?o ?g. }
- W3204903367 endingPage "1566" @default.
- W3204903367 startingPage "1551" @default.
- W3204903367 abstract "The aim was to perform an umbrella review to summarise the existing evidence on proton-pump inhibitor (PPI) use and adverse outcomes and to grade the certainty of evidence.Electronic databases were searched up to July 2021 for meta-analyses of cohort studies and/or randomised controlled trials (RCTs). Summary effect sizes from a random-effects model, between-study heterogeneity, 95% prediction interval, small-study effect, excess significance and credibility ceilings were devised to classify the credibility of evidence from meta-analyses of cohort studies, whereas the GRADE approach was used for meta-analyses of RCTs.In meta-analyses of cohort studies, 52 of the 91 examined associations were statistically significant (P ≤ .05). Convincing evidence emerged from main analysis for the association between PPI use and risk of all-site fracture and chronic kidney disease in the elderly population. However, none of these associations remained supported by convincing evidence after sensitivity analyses. The use of PPI is also associated with an increased risk of mortality due to COVID-19 infection and other related adverse outcomes, but the quality of evidence was weak. In meta-analyses of RCTs, 38 of the 63 examined associations were statistically significant. However, no associations were supported by high or moderate-quality evidence.This study's findings imply that most putative adverse outcomes associated with PPI use may not be supported by high-quality evidence and are likely to have been affected by underlying confounding factors. Future research is needed to confirm the causal association between PPI use and risk of fracture and chronic kidney disease." @default.
- W3204903367 created "2021-10-11" @default.
- W3204903367 creator A5008105139 @default.
- W3204903367 creator A5013349830 @default.
- W3204903367 creator A5021457387 @default.
- W3204903367 creator A5031442144 @default.
- W3204903367 creator A5044348871 @default.
- W3204903367 creator A5044392782 @default.
- W3204903367 creator A5053038836 @default.
- W3204903367 creator A5053753652 @default.
- W3204903367 creator A5057670631 @default.
- W3204903367 creator A5058126906 @default.
- W3204903367 creator A5083299273 @default.
- W3204903367 date "2021-10-31" @default.
- W3204903367 modified "2023-10-13" @default.
- W3204903367 title "Association of proton‐pump inhibitor use with adverse health outcomes: A systematic umbrella review of meta‐analyses of cohort studies and randomised controlled trials" @default.
- W3204903367 cites W1489584806 @default.
- W3204903367 cites W1496904506 @default.
- W3204903367 cites W1759444692 @default.
- W3204903367 cites W1806512189 @default.
- W3204903367 cites W1973914781 @default.
- W3204903367 cites W1978559333 @default.
- W3204903367 cites W1979423827 @default.
- W3204903367 cites W1980111788 @default.
- W3204903367 cites W1984850666 @default.
- W3204903367 cites W2001871336 @default.
- W3204903367 cites W2010361292 @default.
- W3204903367 cites W2037053629 @default.
- W3204903367 cites W2073677120 @default.
- W3204903367 cites W2080815850 @default.
- W3204903367 cites W2104675861 @default.
- W3204903367 cites W2105377907 @default.
- W3204903367 cites W2107328434 @default.
- W3204903367 cites W2108868101 @default.
- W3204903367 cites W2113443314 @default.
- W3204903367 cites W2125435699 @default.
- W3204903367 cites W2133413753 @default.
- W3204903367 cites W2144766297 @default.
- W3204903367 cites W2153049285 @default.
- W3204903367 cites W2157823046 @default.
- W3204903367 cites W2163408766 @default.
- W3204903367 cites W2171710347 @default.
- W3204903367 cites W2206022736 @default.
- W3204903367 cites W2284502548 @default.
- W3204903367 cites W2371838261 @default.
- W3204903367 cites W2395736350 @default.
- W3204903367 cites W2482994559 @default.
- W3204903367 cites W2483193311 @default.
- W3204903367 cites W2510105370 @default.
- W3204903367 cites W2531269403 @default.
- W3204903367 cites W2550831966 @default.
- W3204903367 cites W2570328141 @default.
- W3204903367 cites W2589903002 @default.
- W3204903367 cites W2593141353 @default.
- W3204903367 cites W2609793605 @default.
- W3204903367 cites W2616090804 @default.
- W3204903367 cites W2616141209 @default.
- W3204903367 cites W2737359938 @default.
- W3204903367 cites W2749316061 @default.
- W3204903367 cites W2756578555 @default.
- W3204903367 cites W2759589333 @default.
- W3204903367 cites W2766776218 @default.
- W3204903367 cites W2781278043 @default.
- W3204903367 cites W2782932232 @default.
- W3204903367 cites W2783295940 @default.
- W3204903367 cites W2787360615 @default.
- W3204903367 cites W2793094926 @default.
- W3204903367 cites W2794435124 @default.
- W3204903367 cites W2795948121 @default.
- W3204903367 cites W2799865262 @default.
- W3204903367 cites W2802643432 @default.
- W3204903367 cites W2811131397 @default.
- W3204903367 cites W2886144609 @default.
- W3204903367 cites W2888861054 @default.
- W3204903367 cites W2890396148 @default.
- W3204903367 cites W2891986754 @default.
- W3204903367 cites W2896782950 @default.
- W3204903367 cites W2897234648 @default.
- W3204903367 cites W2898214921 @default.
- W3204903367 cites W2901230849 @default.
- W3204903367 cites W2903706901 @default.
- W3204903367 cites W2907074747 @default.
- W3204903367 cites W2921669446 @default.
- W3204903367 cites W2929614885 @default.
- W3204903367 cites W2931824106 @default.
- W3204903367 cites W2943411653 @default.
- W3204903367 cites W2946868571 @default.
- W3204903367 cites W2955331731 @default.
- W3204903367 cites W2961265388 @default.
- W3204903367 cites W2964183949 @default.
- W3204903367 cites W2972361570 @default.
- W3204903367 cites W2977696925 @default.
- W3204903367 cites W2980261817 @default.
- W3204903367 cites W2991567289 @default.
- W3204903367 cites W2998775006 @default.
- W3204903367 cites W2999251310 @default.
- W3204903367 cites W2999930483 @default.
- W3204903367 cites W3006822124 @default.