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- W3204912499 abstract "Parkinson's disease (PD) is the second-most common neurodegenerative disorder after Alzheimer's disease. The discovery of gene mutations associated with the onset of PD has allowed the creation of multiple animal models of PD to better understand the molecular mechanisms and pathophysiology of this disorder. Autophagy is an essential catabolic process that regulates cellular homeostasis. Autophagy also plays a role in safeguarding energy homeostasis, and dysregulation of this process often leads to neurodegeneration. Strikingly, many of the genes identified as causing inherited forms of PD have functional roles in various aspects of autophagy, and the mutations that cause or contribute to PD can also disrupt normal autophagic activity. This chapter introduces the pathophysiological interplay of autophagy and PD with a focus on Parkin, PTEN-induced putative kinase 1, α-synuclein, vacuolar protein sorting-associated protein 35, PARK7 (aka DJ-1), leucine-rich repeat kinase 2, and synaptojanin-1 and the roles they play in regulating autophagy and the onset of PD. In summary, this chapter discusses novel therapeutic approaches that aim to treat PD by targeting autophagic pathways." @default.
- W3204912499 created "2021-10-11" @default.
- W3204912499 creator A5036957067 @default.
- W3204912499 creator A5041696149 @default.
- W3204912499 creator A5055742429 @default.
- W3204912499 creator A5066818655 @default.
- W3204912499 creator A5087392254 @default.
- W3204912499 date "2022-01-01" @default.
- W3204912499 modified "2023-09-26" @default.
- W3204912499 title "Altered autophagy on the path to Parkinson's disease" @default.
- W3204912499 cites W1408841334 @default.
- W3204912499 cites W1561072761 @default.
- W3204912499 cites W1838543656 @default.
- W3204912499 cites W1953962861 @default.
- W3204912499 cites W1965709240 @default.
- W3204912499 cites W1965940344 @default.
- W3204912499 cites W1987155530 @default.
- W3204912499 cites W1993201929 @default.
- W3204912499 cites W1999679029 @default.
- W3204912499 cites W2003638886 @default.
- W3204912499 cites W2008886854 @default.
- W3204912499 cites W2026175550 @default.
- W3204912499 cites W2027096397 @default.
- W3204912499 cites W2044775784 @default.
- W3204912499 cites W2046237540 @default.
- W3204912499 cites W2051362437 @default.
- W3204912499 cites W2058568944 @default.
- W3204912499 cites W2059107485 @default.
- W3204912499 cites W2064127635 @default.
- W3204912499 cites W2068288454 @default.
- W3204912499 cites W2074833985 @default.
- W3204912499 cites W2075407995 @default.
- W3204912499 cites W2075832622 @default.
- W3204912499 cites W2080967954 @default.
- W3204912499 cites W2091704417 @default.
- W3204912499 cites W2100300726 @default.
- W3204912499 cites W2108326484 @default.
- W3204912499 cites W2110157421 @default.
- W3204912499 cites W2112001589 @default.
- W3204912499 cites W2119399459 @default.
- W3204912499 cites W2126478464 @default.
- W3204912499 cites W2128184553 @default.
- W3204912499 cites W2130444809 @default.
- W3204912499 cites W2133962007 @default.
- W3204912499 cites W2148635688 @default.
- W3204912499 cites W2150634893 @default.
- W3204912499 cites W2155015733 @default.
- W3204912499 cites W2163628807 @default.
- W3204912499 cites W2166348969 @default.
- W3204912499 cites W2292412857 @default.
- W3204912499 cites W2319983227 @default.
- W3204912499 cites W2329808372 @default.
- W3204912499 cites W2343459310 @default.
- W3204912499 cites W2354149992 @default.
- W3204912499 cites W2411236419 @default.
- W3204912499 cites W2425597023 @default.
- W3204912499 cites W2498411827 @default.
- W3204912499 cites W2525996450 @default.
- W3204912499 cites W2527601118 @default.
- W3204912499 cites W2527849633 @default.
- W3204912499 cites W2529778423 @default.
- W3204912499 cites W2582220264 @default.
- W3204912499 cites W2582745502 @default.
- W3204912499 cites W2586065799 @default.
- W3204912499 cites W2591120401 @default.
- W3204912499 cites W2592067246 @default.
- W3204912499 cites W2599105491 @default.
- W3204912499 cites W2599766179 @default.
- W3204912499 cites W2600495731 @default.
- W3204912499 cites W2601351914 @default.
- W3204912499 cites W2603225623 @default.
- W3204912499 cites W2605074507 @default.
- W3204912499 cites W2609085690 @default.
- W3204912499 cites W2612991505 @default.
- W3204912499 cites W2739956201 @default.
- W3204912499 cites W2743091325 @default.
- W3204912499 cites W2746951261 @default.
- W3204912499 cites W2754278602 @default.
- W3204912499 cites W2755007939 @default.
- W3204912499 cites W2766395183 @default.
- W3204912499 cites W2766537970 @default.
- W3204912499 cites W2771146782 @default.
- W3204912499 cites W2771688344 @default.
- W3204912499 cites W2775438617 @default.
- W3204912499 cites W2782592927 @default.
- W3204912499 cites W2791425412 @default.
- W3204912499 cites W2792440034 @default.
- W3204912499 cites W2794133709 @default.
- W3204912499 cites W2794376990 @default.
- W3204912499 cites W2795906582 @default.
- W3204912499 cites W2800058412 @default.
- W3204912499 cites W2805183985 @default.
- W3204912499 cites W2805234895 @default.
- W3204912499 cites W2806031622 @default.
- W3204912499 cites W2807129716 @default.
- W3204912499 cites W2824830902 @default.
- W3204912499 cites W2842695692 @default.
- W3204912499 cites W2883183613 @default.