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- W3204934178 abstract "Oxidative stress plays an important role in the development of inflammatory diseases including allergy, heart disease, diabetes and cancer. Nanomaterial-mediated antioxidant therapy is regarded as a promising strategy to treat oxidative stress-mediated inflammation. Herein, defective Ag-In-S/ZnS quantum dots (AIS/ZnS QDs) with oxygen-derived radical-scavenging capabilities are developed. Owing to their intrinsic defects and abundant surface functional groups, these quantum dots exhibit excellent oxygen-derived free radical removal efficiency in vitro. In macrophages, AIS/ZnS QDs can eliminate intracellular excessive ROS stimulated by either H2O2 or lipopolysaccharide (LPS), thus can effectively protect macrophages against ROS-induced oxidative injury. Moreover, in the model of LPS-triggered macrophage inflammation, they exhibit benign anti-inflammatory ability by inhibiting the expression of related proinflammatory cytokines (e.g., TNF-α and IL-6). These findings indicate that AIS/ZnS QDs hold great potential for the treatment of ROS-related inflammatory disorders." @default.
- W3204934178 created "2021-10-11" @default.
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- W3204934178 date "2021-01-01" @default.
- W3204934178 modified "2023-10-18" @default.
- W3204934178 title "Defective Ag–In–S/ZnS quantum dots: an oxygen-derived free radical scavenger for mitigating macrophage inflammation" @default.
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- W3204934178 doi "https://doi.org/10.1039/d1tb01681d" @default.
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