Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204951202> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W3204951202 endingPage "115" @default.
- W3204951202 startingPage "115" @default.
- W3204951202 abstract "Objective: Quercetin-3-O-β-D-glucuronide (QG) can alleviate immunological bone marrow failure (BMF) by increasing platelet counts. However, the principal mechanism is less known. This study aimed at deciphering the possible underlying mechanism of QG that is indicated in thrombocytopenic purpura. Methods: In vitro and in vivo experiments were carried out for investigating the mechanism behind QG-facilitated inhibition of mitochondrial pathway-mediated excessive apoptosis of platelets through the phosphatidylinositol-3-kinase (PI3K)/AKT pathway. Results: Our results revealed that QG, the main effective ingredient of Herba Sarcandrae, increases the number of platelets and decreases the expression of Bax, Bad, Bid, and caspase-9 in immunological BMF, indicating the inhibition of mitochondrial pathway-mediated apoptosis. Moreover, we found that the protein and mRNA expressions, as well as the phosphorylated levels of PI3K and AKT, were increased significantly by QG, suggesting the activation of the PI3K/AKT pathway. Furthermore, the inhibition of the PI3K/AKT pathway by LY294002 antagonizes the effects of QG on platelet counts and mitochondrial pathway-mediated apoptosis. Conclusion: We demonstrate that QG inhibits the mitochondria pathway-mediated platelet apoptosis via the PI3K/AKT pathway in immunological BMF. This study thus sheds light on exploring the possible regulatory mechanism of traditional Chinese medicine in the treatment of thrombocytopenia induced by BMF." @default.
- W3204951202 created "2021-10-11" @default.
- W3204951202 creator A5003324293 @default.
- W3204951202 creator A5033844087 @default.
- W3204951202 creator A5060124456 @default.
- W3204951202 creator A5062253236 @default.
- W3204951202 creator A5070115510 @default.
- W3204951202 creator A5070302653 @default.
- W3204951202 creator A5086385437 @default.
- W3204951202 creator A5089209050 @default.
- W3204951202 date "2022-01-01" @default.
- W3204951202 modified "2023-09-25" @default.
- W3204951202 title "Quercetin-3-O-β-D-glucuronide inhibits mitochondria pathway-mediated platelet apoptosis via the phosphatidylinositol-3-kinase/AKT pathway in immunological bone marrow failure" @default.
- W3204951202 cites W1564187542 @default.
- W3204951202 cites W1980301780 @default.
- W3204951202 cites W1998100237 @default.
- W3204951202 cites W2039889642 @default.
- W3204951202 cites W2119503768 @default.
- W3204951202 cites W2121939895 @default.
- W3204951202 cites W2128904039 @default.
- W3204951202 cites W2134580924 @default.
- W3204951202 cites W2161241686 @default.
- W3204951202 cites W2164412125 @default.
- W3204951202 cites W2346277053 @default.
- W3204951202 cites W2781859546 @default.
- W3204951202 cites W2884544738 @default.
- W3204951202 cites W2923776014 @default.
- W3204951202 cites W3017153035 @default.
- W3204951202 cites W3027436419 @default.
- W3204951202 cites W966804235 @default.
- W3204951202 doi "https://doi.org/10.4103/wjtcm.wjtcm_44_21" @default.
- W3204951202 hasPublicationYear "2022" @default.
- W3204951202 type Work @default.
- W3204951202 sameAs 3204951202 @default.
- W3204951202 citedByCount "7" @default.
- W3204951202 countsByYear W32049512022022 @default.
- W3204951202 countsByYear W32049512022023 @default.
- W3204951202 crossrefType "journal-article" @default.
- W3204951202 hasAuthorship W3204951202A5003324293 @default.
- W3204951202 hasAuthorship W3204951202A5033844087 @default.
- W3204951202 hasAuthorship W3204951202A5060124456 @default.
- W3204951202 hasAuthorship W3204951202A5062253236 @default.
- W3204951202 hasAuthorship W3204951202A5070115510 @default.
- W3204951202 hasAuthorship W3204951202A5070302653 @default.
- W3204951202 hasAuthorship W3204951202A5086385437 @default.
- W3204951202 hasAuthorship W3204951202A5089209050 @default.
- W3204951202 hasBestOaLocation W32049512021 @default.
- W3204951202 hasConcept C185592680 @default.
- W3204951202 hasConcept C190283241 @default.
- W3204951202 hasConcept C203014093 @default.
- W3204951202 hasConcept C2776912716 @default.
- W3204951202 hasConcept C2780007613 @default.
- W3204951202 hasConcept C2780610907 @default.
- W3204951202 hasConcept C502942594 @default.
- W3204951202 hasConcept C55493867 @default.
- W3204951202 hasConcept C62478195 @default.
- W3204951202 hasConcept C75217442 @default.
- W3204951202 hasConcept C86554907 @default.
- W3204951202 hasConcept C86803240 @default.
- W3204951202 hasConcept C89560881 @default.
- W3204951202 hasConcept C95444343 @default.
- W3204951202 hasConcept C98274493 @default.
- W3204951202 hasConceptScore W3204951202C185592680 @default.
- W3204951202 hasConceptScore W3204951202C190283241 @default.
- W3204951202 hasConceptScore W3204951202C203014093 @default.
- W3204951202 hasConceptScore W3204951202C2776912716 @default.
- W3204951202 hasConceptScore W3204951202C2780007613 @default.
- W3204951202 hasConceptScore W3204951202C2780610907 @default.
- W3204951202 hasConceptScore W3204951202C502942594 @default.
- W3204951202 hasConceptScore W3204951202C55493867 @default.
- W3204951202 hasConceptScore W3204951202C62478195 @default.
- W3204951202 hasConceptScore W3204951202C75217442 @default.
- W3204951202 hasConceptScore W3204951202C86554907 @default.
- W3204951202 hasConceptScore W3204951202C86803240 @default.
- W3204951202 hasConceptScore W3204951202C89560881 @default.
- W3204951202 hasConceptScore W3204951202C95444343 @default.
- W3204951202 hasConceptScore W3204951202C98274493 @default.
- W3204951202 hasIssue "1" @default.
- W3204951202 hasLocation W32049512021 @default.
- W3204951202 hasLocation W32049512022 @default.
- W3204951202 hasOpenAccess W3204951202 @default.
- W3204951202 hasPrimaryLocation W32049512021 @default.
- W3204951202 hasRelatedWork W2020067517 @default.
- W3204951202 hasRelatedWork W2051069156 @default.
- W3204951202 hasRelatedWork W2124592445 @default.
- W3204951202 hasRelatedWork W2167746858 @default.
- W3204951202 hasRelatedWork W2169339192 @default.
- W3204951202 hasRelatedWork W2278983970 @default.
- W3204951202 hasRelatedWork W2356558710 @default.
- W3204951202 hasRelatedWork W2376777987 @default.
- W3204951202 hasRelatedWork W2603762427 @default.
- W3204951202 hasRelatedWork W3029800644 @default.
- W3204951202 hasVolume "8" @default.
- W3204951202 isParatext "false" @default.
- W3204951202 isRetracted "false" @default.
- W3204951202 magId "3204951202" @default.
- W3204951202 workType "article" @default.