FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204952600> ?p ?o ?g. }

• W3204952600 endingPage "2682" @default.
• W3204952600 startingPage "2682" @default.
• W3204952600 abstract "The incidence of spinal cord injury (SCI) is ever-growing, resulting in life-changing neurological deficits which can have devastating long-term impacts on a person's quality of life. There is an unmet clinical need for a treatment which will prevent progression of the injury, allowing improved axonal regeneration and functional recovery to occur. The initial mechanical insult, followed by a cascade of secondary mechanisms, leads to the exacerbation and remodelling of the lesion site, thus inhibiting neurological recovery. Oedema rapidly accumulates following SCI and contributes to the detrimental pathophysiology and worsens functional outcomes. This study systematically reviewed the current experimental treatments being explored in the field of SCI, which specifically target oedema. Abiding by PRISMA guidelines and strict inclusion criteria, 14 studies were identified and analysed from three online databases (PubMed, Web of Science and EMBASE). As a result, we identified three key modalities which attenuate oedema: selective inhibition of the main water channel protein, aquaporin 4 (AQP4), modulation of inflammation and surgical interventions. Collectively, however, they all result in the downregulation of AQP4, which crucially leads to a reduction in oedema and improved functional outcomes. We concluded that trifluoperazine (TFP), a calmodulin kinase inhibitor which prevents the cell-surface localisation of AQP4, was the most efficacious treatment, significantly eliminating oedema within 7 days of administration. To date, this study is the most concise analysis of current experimental treatments for oedema, exposing its molecular mechanisms and assessing potential therapeutic pathways for future research." @default.
• W3204952600 created "2021-10-11" @default.
• W3204952600 creator A5018219383 @default.
• W3204952600 creator A5042926722 @default.
• W3204952600 date "2021-10-07" @default.
• W3204952600 modified "2023-10-06" @default.
• W3204952600 title "Experimental Treatments for Oedema in Spinal Cord Injury: A Systematic Review and Meta-Analysis" @default.
• W3204952600 cites W1908112684 @default.
• W3204952600 cites W1964811607 @default.
• W3204952600 cites W1971879128 @default.
• W3204952600 cites W1997781927 @default.
• W3204952600 cites W2003807726 @default.
• W3204952600 cites W2025416757 @default.
• W3204952600 cites W2034199603 @default.
• W3204952600 cites W2035120744 @default.
• W3204952600 cites W2048153910 @default.
• W3204952600 cites W2058571677 @default.
• W3204952600 cites W2058678069 @default.
• W3204952600 cites W2084445731 @default.
• W3204952600 cites W2085462946 @default.
• W3204952600 cites W2098017869 @default.
• W3204952600 cites W2101966356 @default.
• W3204952600 cites W2102515941 @default.
• W3204952600 cites W2126994317 @default.
• W3204952600 cites W2156098321 @default.
• W3204952600 cites W2165365061 @default.
• W3204952600 cites W2214358211 @default.
• W3204952600 cites W2340255241 @default.
• W3204952600 cites W2474204952 @default.
• W3204952600 cites W2484283047 @default.
• W3204952600 cites W2560629039 @default.
• W3204952600 cites W2612011842 @default.
• W3204952600 cites W2765644437 @default.
• W3204952600 cites W2776849779 @default.
• W3204952600 cites W2790104229 @default.
• W3204952600 cites W2791725149 @default.
• W3204952600 cites W2808800285 @default.
• W3204952600 cites W2827724867 @default.
• W3204952600 cites W2896188878 @default.
• W3204952600 cites W2921258905 @default.
• W3204952600 cites W2924590879 @default.
• W3204952600 cites W2946148409 @default.
• W3204952600 cites W2991792334 @default.
• W3204952600 cites W3007802801 @default.
• W3204952600 cites W3025713031 @default.
• W3204952600 cites W3040773580 @default.
• W3204952600 cites W3043135743 @default.
• W3204952600 cites W3184870912 @default.
• W3204952600 doi "https://doi.org/10.3390/cells10102682" @default.
• W3204952600 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8534777" @default.
• W3204952600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34685662" @default.
• W3204952600 hasPublicationYear "2021" @default.
• W3204952600 type Work @default.
• W3204952600 sameAs 3204952600 @default.
• W3204952600 citedByCount "5" @default.
• W3204952600 countsByYear W32049526002022 @default.
• W3204952600 countsByYear W32049526002023 @default.
• W3204952600 crossrefType "journal-article" @default.
• W3204952600 hasAuthorship W3204952600A5018219383 @default.
• W3204952600 hasAuthorship W3204952600A5042926722 @default.
• W3204952600 hasBestOaLocation W32049526001 @default.
• W3204952600 hasConcept C118552586 @default.
• W3204952600 hasConcept C126322002 @default.
• W3204952600 hasConcept C142724271 @default.
• W3204952600 hasConcept C159110408 @default.
• W3204952600 hasConcept C169760540 @default.
• W3204952600 hasConcept C25498285 @default.
• W3204952600 hasConcept C2778334475 @default.
• W3204952600 hasConcept C2779951463 @default.
• W3204952600 hasConcept C2780775167 @default.
• W3204952600 hasConcept C2780886150 @default.
• W3204952600 hasConcept C2781156865 @default.
• W3204952600 hasConcept C60644358 @default.
• W3204952600 hasConcept C71924100 @default.
• W3204952600 hasConcept C86803240 @default.
• W3204952600 hasConcept C99508421 @default.
• W3204952600 hasConceptScore W3204952600C118552586 @default.
• W3204952600 hasConceptScore W3204952600C126322002 @default.
• W3204952600 hasConceptScore W3204952600C142724271 @default.
• W3204952600 hasConceptScore W3204952600C159110408 @default.
• W3204952600 hasConceptScore W3204952600C169760540 @default.
• W3204952600 hasConceptScore W3204952600C25498285 @default.
• W3204952600 hasConceptScore W3204952600C2778334475 @default.
• W3204952600 hasConceptScore W3204952600C2779951463 @default.
• W3204952600 hasConceptScore W3204952600C2780775167 @default.
• W3204952600 hasConceptScore W3204952600C2780886150 @default.
• W3204952600 hasConceptScore W3204952600C2781156865 @default.
• W3204952600 hasConceptScore W3204952600C60644358 @default.
• W3204952600 hasConceptScore W3204952600C71924100 @default.
• W3204952600 hasConceptScore W3204952600C86803240 @default.
• W3204952600 hasConceptScore W3204952600C99508421 @default.
• W3204952600 hasIssue "10" @default.
• W3204952600 hasLocation W32049526001 @default.
• W3204952600 hasLocation W32049526002 @default.
• W3204952600 hasLocation W32049526003 @default.
• W3204952600 hasLocation W32049526004 @default.
• W3204952600 hasLocation W32049526005 @default.
• W3204952600 hasLocation W32049526006 @default.

• next