FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204989708> ?p ?o ?g. }

• W3204989708 endingPage "4499" @default.
• W3204989708 startingPage "4485" @default.
• W3204989708 abstract "Lymphocytes play an important role in antitumor immunity following organ transplantation. However, the function of granzyme B+CD19+B cells on the hepatocellular carcinoma cells from liver transplant recipients remains largely unknown; we aimed to analyze the function and elucidate the mechanisms behind it. Blood samples and clinical data from liver transplant recipients and healthy controls at Beijing Chaoyang Hospital as well as from a validation cohort were collected and analyzed. In this study, we found decreased granzyme B+CD19+B cells were correlated with early hepatocellular carcinoma recurrence and could further identify liver transplant recipients with poor tumor differentiation, microvascular invasion, increased total tumor diameter, and tumor beyond Milan criteria. Notably, granzyme B+CD19+B cells directly inhibited the proliferation, migration, and invasion of hepatocellular carcinoma cells. Upon activation regulatory B cells from liver transplant recipients with hepatocellular carcinoma recurrence displayed a CD5+CD38+CD27+CD138+CD19+ granzyme B+ phenotype, but the increased expression of CD5, CD38, and CD138, and the decreased protein level and transcriptional level requiring JAK/STAT signaling. In an independent validation cohort, liver transplant recipients with decreased granzyme B+CD19+B cells had not only early hepatocellular carcinoma cell recurrence but also shorter survival. Our study provides comprehensive data from liver transplant recipients with hepatocellular carcinoma, indicating a critical role of granzyme B+CD19+B cells in preventing cancer progression. Our findings warrant further investigations for the design of future immunotherapies leading to immune responses and improved patient survival." @default.
• W3204989708 created "2021-10-25" @default.
• W3204989708 creator A5002768191 @default.
• W3204989708 creator A5005854847 @default.
• W3204989708 creator A5016048407 @default.
• W3204989708 creator A5039274612 @default.
• W3204989708 creator A5050915249 @default.
• W3204989708 creator A5058001448 @default.
• W3204989708 creator A5059283624 @default.
• W3204989708 creator A5084846204 @default.
• W3204989708 creator A5086352151 @default.
• W3204989708 date "2021-01-01" @default.
• W3204989708 modified "2023-09-23" @default.
• W3204989708 title "Decreased granzyme B+CD19+B cells are associated with tumor progression following liver transplantation." @default.
• W3204989708 cites W1529273541 @default.
• W3204989708 cites W1846543575 @default.
• W3204989708 cites W1965894847 @default.
• W3204989708 cites W1973392006 @default.
• W3204989708 cites W1975364025 @default.
• W3204989708 cites W1997632683 @default.
• W3204989708 cites W1997851486 @default.
• W3204989708 cites W2006236831 @default.
• W3204989708 cites W2016278725 @default.
• W3204989708 cites W2047819297 @default.
• W3204989708 cites W2078776989 @default.
• W3204989708 cites W2079649533 @default.
• W3204989708 cites W2088328410 @default.
• W3204989708 cites W2099443640 @default.
• W3204989708 cites W2115876761 @default.
• W3204989708 cites W2118599881 @default.
• W3204989708 cites W2127929077 @default.
• W3204989708 cites W2132561915 @default.
• W3204989708 cites W2147557958 @default.
• W3204989708 cites W2167016095 @default.
• W3204989708 cites W2200842302 @default.
• W3204989708 cites W2204209053 @default.
• W3204989708 cites W2301531244 @default.
• W3204989708 cites W2341757884 @default.
• W3204989708 cites W2434055075 @default.
• W3204989708 cites W2465159560 @default.
• W3204989708 cites W2553293686 @default.
• W3204989708 cites W2609406218 @default.
• W3204989708 cites W2609830515 @default.
• W3204989708 cites W3019022599 @default.
• W3204989708 cites W3120226075 @default.
• W3204989708 cites W3127015740 @default.
• W3204989708 cites W3022176110 @default.
• W3204989708 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8493381" @default.
• W3204989708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34659900" @default.
• W3204989708 hasPublicationYear "2021" @default.
• W3204989708 type Work @default.
• W3204989708 sameAs 3204989708 @default.
• W3204989708 citedByCount "1" @default.
• W3204989708 countsByYear W32049897082023 @default.
• W3204989708 crossrefType "journal-article" @default.
• W3204989708 hasAuthorship W3204989708A5002768191 @default.
• W3204989708 hasAuthorship W3204989708A5005854847 @default.
• W3204989708 hasAuthorship W3204989708A5016048407 @default.
• W3204989708 hasAuthorship W3204989708A5039274612 @default.
• W3204989708 hasAuthorship W3204989708A5050915249 @default.
• W3204989708 hasAuthorship W3204989708A5058001448 @default.
• W3204989708 hasAuthorship W3204989708A5059283624 @default.
• W3204989708 hasAuthorship W3204989708A5084846204 @default.
• W3204989708 hasAuthorship W3204989708A5086352151 @default.
• W3204989708 hasConcept C10205521 @default.
• W3204989708 hasConcept C126322002 @default.
• W3204989708 hasConcept C159912055 @default.
• W3204989708 hasConcept C167672396 @default.
• W3204989708 hasConcept C183193105 @default.
• W3204989708 hasConcept C187316574 @default.
• W3204989708 hasConcept C203014093 @default.
• W3204989708 hasConcept C2776062744 @default.
• W3204989708 hasConcept C2776090121 @default.
• W3204989708 hasConcept C2778019345 @default.
• W3204989708 hasConcept C2778957590 @default.
• W3204989708 hasConcept C2779609443 @default.
• W3204989708 hasConcept C2780380082 @default.
• W3204989708 hasConcept C2781438807 @default.
• W3204989708 hasConcept C28328180 @default.
• W3204989708 hasConcept C2911091166 @default.
• W3204989708 hasConcept C502942594 @default.
• W3204989708 hasConcept C54355233 @default.
• W3204989708 hasConcept C553184892 @default.
• W3204989708 hasConcept C71924100 @default.
• W3204989708 hasConcept C86803240 @default.
• W3204989708 hasConcept C8891405 @default.
• W3204989708 hasConceptScore W3204989708C10205521 @default.
• W3204989708 hasConceptScore W3204989708C126322002 @default.
• W3204989708 hasConceptScore W3204989708C159912055 @default.
• W3204989708 hasConceptScore W3204989708C167672396 @default.
• W3204989708 hasConceptScore W3204989708C183193105 @default.
• W3204989708 hasConceptScore W3204989708C187316574 @default.
• W3204989708 hasConceptScore W3204989708C203014093 @default.
• W3204989708 hasConceptScore W3204989708C2776062744 @default.
• W3204989708 hasConceptScore W3204989708C2776090121 @default.
• W3204989708 hasConceptScore W3204989708C2778019345 @default.
• W3204989708 hasConceptScore W3204989708C2778957590 @default.
• W3204989708 hasConceptScore W3204989708C2779609443 @default.

• next