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- W3204990462 abstract "(Cell 119, 815–829; December 17, 2004) Immunoblots in Figures 2C (HA-Nucleolin) and 2B (HA-PARP1) are erroneous duplications incorrectly inserted during the preparation of the figures. The corrected panels are included in the figure shown here. This error in figure preparation does not alter the conclusions in the manuscript. Activating the PARP-1 Sensor Component of the Groucho/ TLE1 Corepressor Complex Mediates a CaMKinase IIδ-Dependent Neurogenic Gene Activation PathwayJu et al.CellDecember 17, 2004In BriefSwitching specific patterns of gene repression and activation in response to precise temporal/spatial signals is critical for normal development. Here we report a pathway in which induction of CaMKIIδ triggers an unexpected switch in the function of the HES1 transcription factor from a TLE-dependent repressor to an activator required for neuronal differentiation. These events are based on activation of the poly(ADP-ribose) polymerase1 (PARP-1) sensor component of the groucho/TLE-corepressor complex mediating dismissal of the corepressor complex from HES1-regulated promoters. Full-Text PDF Open Archive" @default.
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- W3204990462 date "2006-12-01" @default.
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- W3204990462 title "Activating the PARP-1 Sensor Component of the Groucho/ TLE1 Corepressor Complex Mediates a CaMKinase IIδ-Dependent Neurogenic Gene Activation Pathway" @default.
- W3204990462 doi "https://doi.org/10.1016/j.cell.2006.11.028" @default.
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