FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204992151> ?p ?o ?g. }

• W3204992151 abstract "Since autophagy and the immune microenvironment are deeply involved in the tumor development and progression of Lower-grade gliomas (LGG), our study aimed to construct an autophagy-related risk model for prognosis prediction and investigate the relationship between the immune microenvironment and risk signature in LGG. Therefore, we identified six autophagy-related genes (BAG1, PTK6, EEF2, PEA15, ITGA6, and MAP1LC3C) to build in the training cohort (n = 305 patients) and verify the prognostic model in the validation cohort (n = 128) and the whole cohort (n = 433), based on the data from The Cancer Genome Atlas (TCGA). The six-gene risk signature could divide LGG patients into high- and low-risk groups with distinct overall survival in multiple cohorts (all p < 0.001). The prognostic effect was assessed by area under the time-dependent ROC (t-ROC) analysis in the training, validation, and whole cohorts, in which the AUC value at the survival time of 5 years was 0.837, 0.755, and 0.803, respectively. Cox regression analysis demonstrated that the risk model was an independent risk predictor of OS (HR > 1, p < 0.05). A nomogram including the traditional clinical parameters and risk signature was constructed, and t-ROC, C-index, and calibration curves confirmed its robust predictive capacity. KM analysis revealed a significant difference in the subgroup analyses' survival. Functional enrichment analysis revealed that these autophagy-related signatures were mainly involved in the phagosome and immune-related pathways. Besides, we also found significant differences in immune cell infiltration and immunotherapy targets between risk groups. In conclusion, we built a powerful predictive signature and explored immune components (including immune cells and emerging immunotherapy targets) in LGG." @default.
• W3204992151 created "2021-10-25" @default.
• W3204992151 creator A5007910885 @default.
• W3204992151 creator A5013885184 @default.
• W3204992151 creator A5016755232 @default.
• W3204992151 creator A5020048246 @default.
• W3204992151 creator A5027872311 @default.
• W3204992151 creator A5042170464 @default.
• W3204992151 creator A5042572280 @default.
• W3204992151 creator A5046908034 @default.
• W3204992151 creator A5051416943 @default.
• W3204992151 creator A5052348782 @default.
• W3204992151 creator A5065911177 @default.
• W3204992151 creator A5068049337 @default.
• W3204992151 creator A5069731960 @default.
• W3204992151 creator A5074200075 @default.
• W3204992151 creator A5079128182 @default.
• W3204992151 creator A5086010002 @default.
• W3204992151 creator A5086078104 @default.
• W3204992151 date "2021-10-13" @default.
• W3204992151 modified "2023-10-13" @default.
• W3204992151 title "A Novel Six Autophagy-Related Genes Signature Associated With Outcomes and Immune Microenvironment in Lower-Grade Glioma" @default.
• W3204992151 cites W1533942137 @default.
• W3204992151 cites W1569307548 @default.
• W3204992151 cites W1682599886 @default.
• W3204992151 cites W1812256879 @default.
• W3204992151 cites W1952196658 @default.
• W3204992151 cites W1966292905 @default.
• W3204992151 cites W1975146254 @default.
• W3204992151 cites W1977841275 @default.
• W3204992151 cites W1985987855 @default.
• W3204992151 cites W1992346696 @default.
• W3204992151 cites W1992828394 @default.
• W3204992151 cites W1993643473 @default.
• W3204992151 cites W1996908572 @default.
• W3204992151 cites W2000738821 @default.
• W3204992151 cites W2001623365 @default.
• W3204992151 cites W2006344933 @default.
• W3204992151 cites W2009879287 @default.
• W3204992151 cites W2010573862 @default.
• W3204992151 cites W2012430921 @default.
• W3204992151 cites W2035307176 @default.
• W3204992151 cites W2035618305 @default.
• W3204992151 cites W2039607936 @default.
• W3204992151 cites W2055954434 @default.
• W3204992151 cites W2065552179 @default.
• W3204992151 cites W2074176106 @default.
• W3204992151 cites W2082202424 @default.
• W3204992151 cites W2101228747 @default.
• W3204992151 cites W2101909769 @default.
• W3204992151 cites W2117692326 @default.
• W3204992151 cites W2121175301 @default.
• W3204992151 cites W2132020367 @default.
• W3204992151 cites W2137448586 @default.
• W3204992151 cites W2138196293 @default.
• W3204992151 cites W2139591061 @default.
• W3204992151 cites W2141713919 @default.
• W3204992151 cites W2146512944 @default.
• W3204992151 cites W2148847731 @default.
• W3204992151 cites W2148977460 @default.
• W3204992151 cites W2154176599 @default.
• W3204992151 cites W2154618359 @default.
• W3204992151 cites W2158617540 @default.
• W3204992151 cites W2163147674 @default.
• W3204992151 cites W2170649132 @default.
• W3204992151 cites W2308789672 @default.
• W3204992151 cites W2344221521 @default.
• W3204992151 cites W2366536035 @default.
• W3204992151 cites W2527850257 @default.
• W3204992151 cites W2527905628 @default.
• W3204992151 cites W2547394998 @default.
• W3204992151 cites W2567692508 @default.
• W3204992151 cites W2585539786 @default.
• W3204992151 cites W2614556404 @default.
• W3204992151 cites W2734298333 @default.
• W3204992151 cites W2750745141 @default.
• W3204992151 cites W2761081415 @default.
• W3204992151 cites W2762658547 @default.
• W3204992151 cites W2766210434 @default.
• W3204992151 cites W2773100646 @default.
• W3204992151 cites W2793487548 @default.
• W3204992151 cites W2804534898 @default.
• W3204992151 cites W2808617417 @default.
• W3204992151 cites W2903194698 @default.
• W3204992151 cites W2914075439 @default.
• W3204992151 cites W2915867138 @default.
• W3204992151 cites W2948226669 @default.
• W3204992151 cites W2978668158 @default.
• W3204992151 cites W3002319954 @default.
• W3204992151 cites W3005468192 @default.
• W3204992151 cites W3031508706 @default.
• W3204992151 cites W3033241536 @default.
• W3204992151 cites W3047176562 @default.
• W3204992151 cites W3093293792 @default.
• W3204992151 cites W4211220688 @default.
• W3204992151 cites W4294541781 @default.
• W3204992151 doi "https://doi.org/10.3389/fgene.2021.698284" @default.
• W3204992151 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8548643" @default.
• W3204992151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34721517" @default.
• W3204992151 hasPublicationYear "2021" @default.

• next