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- W3204993176 abstract "COVID-19 is a global disease and was characterized as a pandemic by the WHO and the coronavirus is caused also damage nervous system. The aim of this study was to investigate the brain tissue of patients who died from COVID-19. We investigated the brains of 15 patients who died from complications of COVID-19. All patients had a positive test for SARS-CoV-2. Information from the autopsy protocol included macroscopic and microscopic characteristics of brain and general autopsy findings. We used immunohistochemistry staining for astrocytes, microglia and T-lymphocytes in the cortex, basal ganglia, brainstem and cerebellum. All patients died in hospitals and had a median age of 65 years (range, 47–80 years), 66.7% male and 33.3% women. Cause of death of most cases was viral pneumonia as the underlying condition. Neuromorphological studies showed fresh ischemic infarction in three (20%) patients with focal encephalolysis. Hypoxic manifestations with neuronal loss in the frontal lobe, basal ganglia, hippocampus, cerebellum were present. In most of cases the arteriolosclerosis with perivascular rarefaction was present. The reactive astrogliosis with positive astrocytic marker GFAP was seen in all cases but showed variable degrees. The perivascular activation of microglia and the microglial nodules with CD68 positive cells were in the cortex, basal ganglia, hippocampus, brainstem, but less in cerebellum. And perivascular infiltration by CD3 was most pronounced in the brainstem. Thus, the morphological changes of the CNS associated with COVID-19 include ischemic infarction with encephalolysis, astrogliosis, microgliosis, perivascular infiltration by CD3 in different regions of the brain." @default.
- W3204993176 created "2021-10-25" @default.
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- W3204993176 date "2021-10-01" @default.
- W3204993176 modified "2023-09-26" @default.
- W3204993176 title "Pathomorphological changes of the brain in patients with COVID-19" @default.
- W3204993176 doi "https://doi.org/10.1016/j.jns.2021.119837" @default.
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