Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204995688> ?p ?o ?g. }
- W3204995688 endingPage "7033" @default.
- W3204995688 startingPage "7023" @default.
- W3204995688 abstract "Gold nanoparticles (AuNPs) with good physical and biological properties are often used in medicine, diagnostics, food, and similar industries. This paper explored an AuNPs drug delivery system that had good target selectivity for folate-receptor overexpressing cells to induce apoptosis.A novel drug delivery system, Au@MPA-PEG-FA-PTX, was developed carrying paclitaxel (PTX) on folic acid (FA) and polyethylene glycol (PEG)-modified AuNPs. The nanomaterial was characterized by transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), and ultraviolet-visible spectroscopy (UV-Vis). Also, the biological activity of the AuNPs drug delivery system was examined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in HL-7702, Hela, SMMC-7721, and HCT-116 cells. Furthermore, apoptotic activity using annexin V-FITC, mitochondrial membrane potential (MMP), and reactive oxygen species (ROS) levels was estimated by flow cytometry and fluorescence microscopy.Au@MPA-PEG-FA-PTX exhibited a distinct core-shell structure with a controllable size of 28±1 nm. Also, the AuNPs maintained good dispersion and spherical shape uniformity before and after modification. The MTT assay revealed good antitumor activity of the Au@MPA-PEG-FA-PTX against the Hela, SMMC-7721, and HCT-116 cells, while Au@MPA-PEG-FA-PTX produced better pharmacological effects than PTX in isolation. Further mechanistic investigation revealed that effective internalization of AuNPs by folate-receptor overexpressing cancer cells induced cell apoptosis through excessive production of intracellular ROS.The AuNPs drug delivery system showed good target selectivity for folate-receptor overexpressing cancer cells to induce target cell-specific apoptosis. These AuNPs may have great potential as theranostic agents such as in cancer." @default.
- W3204995688 created "2021-10-25" @default.
- W3204995688 creator A5002216839 @default.
- W3204995688 creator A5016070883 @default.
- W3204995688 creator A5060110137 @default.
- W3204995688 creator A5063897374 @default.
- W3204995688 creator A5072735744 @default.
- W3204995688 date "2021-10-01" @default.
- W3204995688 modified "2023-09-26" @default.
- W3204995688 title "Evaluation of the Biological Activity of Folic Acid-Modified Paclitaxel-Loaded Gold Nanoparticles" @default.
- W3204995688 cites W1076073978 @default.
- W3204995688 cites W1518531052 @default.
- W3204995688 cites W1967784525 @default.
- W3204995688 cites W1970101659 @default.
- W3204995688 cites W1980069424 @default.
- W3204995688 cites W1991861632 @default.
- W3204995688 cites W2014850701 @default.
- W3204995688 cites W2022849239 @default.
- W3204995688 cites W2025504885 @default.
- W3204995688 cites W2033281188 @default.
- W3204995688 cites W2070464059 @default.
- W3204995688 cites W2080031538 @default.
- W3204995688 cites W2081994183 @default.
- W3204995688 cites W2107319967 @default.
- W3204995688 cites W2113253343 @default.
- W3204995688 cites W2137634849 @default.
- W3204995688 cites W2315379364 @default.
- W3204995688 cites W2321016242 @default.
- W3204995688 cites W2331722582 @default.
- W3204995688 cites W2341840741 @default.
- W3204995688 cites W2406474812 @default.
- W3204995688 cites W2411817115 @default.
- W3204995688 cites W2612980447 @default.
- W3204995688 cites W2757926682 @default.
- W3204995688 cites W2776231048 @default.
- W3204995688 cites W2894151845 @default.
- W3204995688 cites W2898533848 @default.
- W3204995688 cites W2900366105 @default.
- W3204995688 cites W2903652532 @default.
- W3204995688 cites W2943106036 @default.
- W3204995688 cites W2946277620 @default.
- W3204995688 cites W2966258649 @default.
- W3204995688 cites W2970636828 @default.
- W3204995688 cites W2976149452 @default.
- W3204995688 cites W2977519477 @default.
- W3204995688 cites W2980970575 @default.
- W3204995688 cites W2989611741 @default.
- W3204995688 cites W2998664017 @default.
- W3204995688 cites W3000153528 @default.
- W3204995688 cites W3005982878 @default.
- W3204995688 cites W3009586897 @default.
- W3204995688 cites W3011895213 @default.
- W3204995688 cites W3028862936 @default.
- W3204995688 cites W3037825970 @default.
- W3204995688 cites W3042775835 @default.
- W3204995688 cites W3044931740 @default.
- W3204995688 cites W3081456660 @default.
- W3204995688 cites W3093860619 @default.
- W3204995688 cites W3106122994 @default.
- W3204995688 cites W3116812615 @default.
- W3204995688 cites W3124078372 @default.
- W3204995688 cites W3126576372 @default.
- W3204995688 cites W3134597133 @default.
- W3204995688 cites W3137867853 @default.
- W3204995688 doi "https://doi.org/10.2147/ijn.s322856" @default.
- W3204995688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8526948" @default.
- W3204995688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34703225" @default.
- W3204995688 hasPublicationYear "2021" @default.
- W3204995688 type Work @default.
- W3204995688 sameAs 3204995688 @default.
- W3204995688 citedByCount "7" @default.
- W3204995688 countsByYear W32049956882022 @default.
- W3204995688 countsByYear W32049956882023 @default.
- W3204995688 crossrefType "journal-article" @default.
- W3204995688 hasAuthorship W3204995688A5002216839 @default.
- W3204995688 hasAuthorship W3204995688A5016070883 @default.
- W3204995688 hasAuthorship W3204995688A5060110137 @default.
- W3204995688 hasAuthorship W3204995688A5063897374 @default.
- W3204995688 hasAuthorship W3204995688A5072735744 @default.
- W3204995688 hasBestOaLocation W32049956881 @default.
- W3204995688 hasConcept C10138342 @default.
- W3204995688 hasConcept C104819515 @default.
- W3204995688 hasConcept C121608353 @default.
- W3204995688 hasConcept C12554922 @default.
- W3204995688 hasConcept C1491633281 @default.
- W3204995688 hasConcept C155672457 @default.
- W3204995688 hasConcept C162324750 @default.
- W3204995688 hasConcept C171250308 @default.
- W3204995688 hasConcept C178790620 @default.
- W3204995688 hasConcept C185592680 @default.
- W3204995688 hasConcept C190283241 @default.
- W3204995688 hasConcept C192562407 @default.
- W3204995688 hasConcept C2776964284 @default.
- W3204995688 hasConcept C2777366897 @default.
- W3204995688 hasConcept C2779820397 @default.
- W3204995688 hasConcept C2780306303 @default.
- W3204995688 hasConcept C2780783641 @default.
- W3204995688 hasConcept C54355233 @default.