FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204998181> ?p ?o ?g. }

• W3204998181 endingPage "9501" @default.
• W3204998181 startingPage "9501" @default.
• W3204998181 abstract "In vitro culture of endothelial cells to form capillary-like networks is essential in tissue engineering. Vascular endothelial growth factor (VEGF) is one of the primary signal proteins stimulating blood vessel formation. This growth factor can be soluble in the medium or protein-bound to the substrate. However, less attention has been paid to distinguishing the specific stimulations by soluble and bound VEGF. We conducted a series of experiments to explore the respective effects of these two VEGF forms. An in-house synthesized biogel comprising a definite concentration of collagen and fibronectin was designed to cultivate human umbilical vein endothelial cells to form the capillary-like network. Collagen served as the primary substrate for cell attachment. Fibronectin provided the surface to bind soluble VEGF in the culture medium to create the bound VEGF. The experiment of adding VEGF-blocking-peptide was conducted to prevent the formation of VEGF bound to the fibronectin domains, to distinguish the respective effects of the soluble and bound VEGF. With the in-house biogel of definite components, we were able to clarify the different roles of soluble and bound VEGF. The results indicated that the soluble VEGF promptly induced the cells to change from round to elongated shape, which contributed to forming network cords. Simultaneously, the bound VEGF provided long-term stimulation, causing the cells to migrate and differentiate into the final capillary-like network." @default.
• W3204998181 created "2021-10-25" @default.
• W3204998181 creator A5006637756 @default.
• W3204998181 creator A5055734857 @default.
• W3204998181 creator A5077937525 @default.
• W3204998181 date "2021-10-13" @default.
• W3204998181 modified "2023-09-26" @default.
• W3204998181 title "Endothelial Cell Morphogenesis and Capillary-like Network Induced by Soluble and Bound VEGF in a Definite Biogel Composed of Collagen and Fibronectin" @default.
• W3204998181 cites W1225109155 @default.
• W3204998181 cites W1573363574 @default.
• W3204998181 cites W1623499339 @default.
• W3204998181 cites W1624346216 @default.
• W3204998181 cites W1969732580 @default.
• W3204998181 cites W1976553848 @default.
• W3204998181 cites W1980122996 @default.
• W3204998181 cites W1985359220 @default.
• W3204998181 cites W1991362893 @default.
• W3204998181 cites W1994719482 @default.
• W3204998181 cites W1996910230 @default.
• W3204998181 cites W2013038209 @default.
• W3204998181 cites W2013170875 @default.
• W3204998181 cites W2015186671 @default.
• W3204998181 cites W2026774353 @default.
• W3204998181 cites W2030537668 @default.
• W3204998181 cites W2041558541 @default.
• W3204998181 cites W2043099950 @default.
• W3204998181 cites W2043744566 @default.
• W3204998181 cites W2049408374 @default.
• W3204998181 cites W2056146626 @default.
• W3204998181 cites W2067363890 @default.
• W3204998181 cites W2074622849 @default.
• W3204998181 cites W2078346682 @default.
• W3204998181 cites W2080452175 @default.
• W3204998181 cites W2088765890 @default.
• W3204998181 cites W2091950308 @default.
• W3204998181 cites W2093142697 @default.
• W3204998181 cites W2094111146 @default.
• W3204998181 cites W2095227131 @default.
• W3204998181 cites W2095572961 @default.
• W3204998181 cites W2103674104 @default.
• W3204998181 cites W2106199085 @default.
• W3204998181 cites W2107583561 @default.
• W3204998181 cites W2114098415 @default.
• W3204998181 cites W2114257111 @default.
• W3204998181 cites W2116326143 @default.
• W3204998181 cites W2130872353 @default.
• W3204998181 cites W2137521271 @default.
• W3204998181 cites W2142634963 @default.
• W3204998181 cites W2232204514 @default.
• W3204998181 cites W2272137666 @default.
• W3204998181 cites W2590515065 @default.
• W3204998181 cites W2619944463 @default.
• W3204998181 cites W2620833969 @default.
• W3204998181 cites W2921434986 @default.
• W3204998181 doi "https://doi.org/10.3390/app11209501" @default.
• W3204998181 hasPublicationYear "2021" @default.
• W3204998181 type Work @default.
• W3204998181 sameAs 3204998181 @default.
• W3204998181 citedByCount "0" @default.
• W3204998181 crossrefType "journal-article" @default.
• W3204998181 hasAuthorship W3204998181A5006637756 @default.
• W3204998181 hasAuthorship W3204998181A5055734857 @default.
• W3204998181 hasAuthorship W3204998181A5077937525 @default.
• W3204998181 hasBestOaLocation W32049981811 @default.
• W3204998181 hasConcept C104317684 @default.
• W3204998181 hasConcept C123012128 @default.
• W3204998181 hasConcept C1491633281 @default.
• W3204998181 hasConcept C167734588 @default.
• W3204998181 hasConcept C185592680 @default.
• W3204998181 hasConcept C202751555 @default.
• W3204998181 hasConcept C203014093 @default.
• W3204998181 hasConcept C2777025900 @default.
• W3204998181 hasConcept C2777411675 @default.
• W3204998181 hasConcept C40692019 @default.
• W3204998181 hasConcept C502942594 @default.
• W3204998181 hasConcept C55493867 @default.
• W3204998181 hasConcept C86492073 @default.
• W3204998181 hasConcept C86803240 @default.
• W3204998181 hasConcept C95444343 @default.
• W3204998181 hasConceptScore W3204998181C104317684 @default.
• W3204998181 hasConceptScore W3204998181C123012128 @default.
• W3204998181 hasConceptScore W3204998181C1491633281 @default.
• W3204998181 hasConceptScore W3204998181C167734588 @default.
• W3204998181 hasConceptScore W3204998181C185592680 @default.
• W3204998181 hasConceptScore W3204998181C202751555 @default.
• W3204998181 hasConceptScore W3204998181C203014093 @default.
• W3204998181 hasConceptScore W3204998181C2777025900 @default.
• W3204998181 hasConceptScore W3204998181C2777411675 @default.
• W3204998181 hasConceptScore W3204998181C40692019 @default.
• W3204998181 hasConceptScore W3204998181C502942594 @default.
• W3204998181 hasConceptScore W3204998181C55493867 @default.
• W3204998181 hasConceptScore W3204998181C86492073 @default.
• W3204998181 hasConceptScore W3204998181C86803240 @default.
• W3204998181 hasConceptScore W3204998181C95444343 @default.
• W3204998181 hasIssue "20" @default.
• W3204998181 hasLocation W32049981811 @default.
• W3204998181 hasLocation W32049981812 @default.
• W3204998181 hasOpenAccess W3204998181 @default.

• next