FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3205000342> ?p ?o ?g. }

• W3205000342 endingPage "237" @default.
• W3205000342 startingPage "228" @default.
• W3205000342 abstract "While emerging evidence indicates that N6-methyladenosine (m6A) regulators play crucial roles in cancer progression, their clinical significance in gastric cancer (GC) has thus far not been elucidated. We investigated the expression of the m6A regulator genes and their prognostic potential in a large clinical cohort of 173 GC patients using qRT-PCR assays. In addition, we undertook a series of in-vitro and in-vivo functional studies to investigate the oncogenic role of FTO. GC patients with low expression of METTL3, METTL14, ALKBH5, WTAP and YTHDF1 demonstrated significantly poor OS, while patients with high FTO expression exhibited markedly worse OS. Furthermore, the cumulative risk-score derived from these gene panel also significantly associated with poor OS, with a corresponding hazard ratio of 5.47 (95% CI: 3.18–9.41, p < 0.0001). We observed that FTO expression was frequently upregulated in GC cell lines, with epithelial-mesenchymal-transition (EMT) features. FTO knockdown in HGC27 and AGS cells inhibited cell proliferation and migratory potential, while its overexpression in MKN28 cells resulted in enhanced proliferation and migration. Finally, confirming our in-vitro findings, FTO suppression led to significant tumour growth inhibition in a HGC27 xenograft model. We demonstrate that m6A regulators may serve as promising prognostic biomarkers in GC. Our functional studies reveal that FTO is an important oncogene and may be a promising therapeutic target associated with EMT-alterations in gastric cancer." @default.
• W3205000342 created "2021-10-25" @default.
• W3205000342 creator A5008862399 @default.
• W3205000342 creator A5010023491 @default.
• W3205000342 creator A5018770643 @default.
• W3205000342 creator A5034105171 @default.
• W3205000342 creator A5043978744 @default.
• W3205000342 creator A5051727905 @default.
• W3205000342 creator A5091114864 @default.
• W3205000342 date "2021-10-21" @default.
• W3205000342 modified "2023-10-18" @default.
• W3205000342 title "Novel evidence for m6A methylation regulators as prognostic biomarkers and FTO as a potential therapeutic target in gastric cancer" @default.
• W3205000342 cites W1534578968 @default.
• W3205000342 cites W1764846306 @default.
• W3205000342 cites W1964081206 @default.
• W3205000342 cites W1991807334 @default.
• W3205000342 cites W2007429249 @default.
• W3205000342 cites W2009315890 @default.
• W3205000342 cites W2022770379 @default.
• W3205000342 cites W2038656195 @default.
• W3205000342 cites W2043891422 @default.
• W3205000342 cites W2052277078 @default.
• W3205000342 cites W2062821957 @default.
• W3205000342 cites W2065847836 @default.
• W3205000342 cites W2071930821 @default.
• W3205000342 cites W2076356670 @default.
• W3205000342 cites W2078964320 @default.
• W3205000342 cites W2091235283 @default.
• W3205000342 cites W2091724447 @default.
• W3205000342 cites W2099540110 @default.
• W3205000342 cites W2104706770 @default.
• W3205000342 cites W2122969281 @default.
• W3205000342 cites W2133956265 @default.
• W3205000342 cites W2154345686 @default.
• W3205000342 cites W2165547003 @default.
• W3205000342 cites W2267322052 @default.
• W3205000342 cites W2306179365 @default.
• W3205000342 cites W2322518056 @default.
• W3205000342 cites W2510949956 @default.
• W3205000342 cites W2533922074 @default.
• W3205000342 cites W2546967042 @default.
• W3205000342 cites W2563912688 @default.
• W3205000342 cites W2584920615 @default.
• W3205000342 cites W2590034108 @default.
• W3205000342 cites W2591489902 @default.
• W3205000342 cites W2600626962 @default.
• W3205000342 cites W2600862208 @default.
• W3205000342 cites W2651879272 @default.
• W3205000342 cites W2748369252 @default.
• W3205000342 cites W2765134354 @default.
• W3205000342 cites W2909321160 @default.
• W3205000342 cites W2943608797 @default.
• W3205000342 cites W2955121251 @default.
• W3205000342 cites W2981028350 @default.
• W3205000342 cites W3012839080 @default.
• W3205000342 cites W3034923646 @default.
• W3205000342 cites W3094581650 @default.
• W3205000342 cites W3119005666 @default.
• W3205000342 cites W3128646645 @default.
• W3205000342 cites W3134195530 @default.
• W3205000342 cites W3154106079 @default.
• W3205000342 cites W3184036706 @default.
• W3205000342 cites W4211233744 @default.
• W3205000342 doi "https://doi.org/10.1038/s41416-021-01581-w" @default.
• W3205000342 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34675398" @default.
• W3205000342 hasPublicationYear "2021" @default.
• W3205000342 type Work @default.
• W3205000342 sameAs 3205000342 @default.
• W3205000342 citedByCount "19" @default.
• W3205000342 countsByYear W32050003422022 @default.
• W3205000342 countsByYear W32050003422023 @default.
• W3205000342 crossrefType "journal-article" @default.
• W3205000342 hasAuthorship W3205000342A5008862399 @default.
• W3205000342 hasAuthorship W3205000342A5010023491 @default.
• W3205000342 hasAuthorship W3205000342A5018770643 @default.
• W3205000342 hasAuthorship W3205000342A5034105171 @default.
• W3205000342 hasAuthorship W3205000342A5043978744 @default.
• W3205000342 hasAuthorship W3205000342A5051727905 @default.
• W3205000342 hasAuthorship W3205000342A5091114864 @default.
• W3205000342 hasBestOaLocation W32050003422 @default.
• W3205000342 hasConcept C104317684 @default.
• W3205000342 hasConcept C121608353 @default.
• W3205000342 hasConcept C126322002 @default.
• W3205000342 hasConcept C127561419 @default.
• W3205000342 hasConcept C143998085 @default.
• W3205000342 hasConcept C173396325 @default.
• W3205000342 hasConcept C2779013556 @default.
• W3205000342 hasConcept C2781018059 @default.
• W3205000342 hasConcept C29537977 @default.
• W3205000342 hasConcept C502942594 @default.
• W3205000342 hasConcept C54355233 @default.
• W3205000342 hasConcept C62112901 @default.
• W3205000342 hasConcept C71924100 @default.
• W3205000342 hasConcept C76419328 @default.
• W3205000342 hasConcept C81885089 @default.
• W3205000342 hasConcept C86803240 @default.
• W3205000342 hasConceptScore W3205000342C104317684 @default.
• W3205000342 hasConceptScore W3205000342C121608353 @default.

• next