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- W3205038140 abstract "Abstract Accurate regulation of cutaneous immunity is fundamental for human health and quality of life but is severely compromised in inflammatory skin disease. To investigate the molecular crosstalk underpinning tolerance vs inflammation in human skin, we set up a human in vivo allergen challenge study, exposing patients with atopic dermatitis (AD) to house dust mite (HDM). Analyses of transcriptional programmes at the population and single cell levels in parallel with immunophenotyping of resident and infiltrating immune cells indicated that inflammatory responses to HDM were associated with immune activation in Langerhans cells (LCs) and cutaneous T cells. High basal level of TNFα production by cutaneous Th17 T cells predisposed to an inflammatory reaction and resulted in formation of hub structures where LCs and T cells interacted, leading to loss of functional programming in LCs. Additionally, single nucleotide polymorphisms in MT1X gene associated with enhanced expression of metallothioneins and transcriptional programmes encoding antioxidant defences across skin cell types in non-reactive patients, were protective against T cell mediated inflammation. Our results provide a unique insight into the dynamics of immune regulation in the human skin and define regulatory circuits that can be harnessed to improve skin health and treat disease." @default.
- W3205038140 created "2021-10-25" @default.
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- W3205038140 date "2021-10-11" @default.
- W3205038140 modified "2023-10-01" @default.
- W3205038140 title "TNFα SIGNALLING IN THE CUTANEOUS IMMUNE NETWORK INSTRUCTS LOCAL Th17 ALLERGEN-SPECIFIC INFLAMMATORY RESPONSES IN ATOPIC DERMATITIS" @default.
- W3205038140 cites W1606922774 @default.
- W3205038140 cites W1966327575 @default.
- W3205038140 cites W1974692569 @default.
- W3205038140 cites W1979758192 @default.
- W3205038140 cites W1984525156 @default.
- W3205038140 cites W2003774999 @default.
- W3205038140 cites W2008810664 @default.
- W3205038140 cites W2011603566 @default.
- W3205038140 cites W2018043147 @default.
- W3205038140 cites W2029673387 @default.
- W3205038140 cites W2035165308 @default.
- W3205038140 cites W2037681298 @default.
- W3205038140 cites W2046580930 @default.
- W3205038140 cites W2050654160 @default.
- W3205038140 cites W2053064795 @default.
- W3205038140 cites W2053134332 @default.
- W3205038140 cites W2063478454 @default.
- W3205038140 cites W2066224059 @default.
- W3205038140 cites W2068259827 @default.
- W3205038140 cites W2068419991 @default.
- W3205038140 cites W2074546623 @default.
- W3205038140 cites W2075541573 @default.
- W3205038140 cites W2086692340 @default.
- W3205038140 cites W2088186226 @default.
- W3205038140 cites W2088412871 @default.
- W3205038140 cites W2090775309 @default.
- W3205038140 cites W2095325567 @default.
- W3205038140 cites W2097091578 @default.
- W3205038140 cites W2102212449 @default.
- W3205038140 cites W2102619694 @default.
- W3205038140 cites W2108234281 @default.
- W3205038140 cites W2114104545 @default.
- W3205038140 cites W2119180969 @default.
- W3205038140 cites W2120334440 @default.
- W3205038140 cites W2124580054 @default.
- W3205038140 cites W2124649657 @default.
- W3205038140 cites W2134582937 @default.
- W3205038140 cites W2143710073 @default.
- W3205038140 cites W2146302565 @default.
- W3205038140 cites W2190545194 @default.
- W3205038140 cites W2278683490 @default.
- W3205038140 cites W2323326409 @default.
- W3205038140 cites W2343858810 @default.
- W3205038140 cites W2345356016 @default.
- W3205038140 cites W2396875337 @default.
- W3205038140 cites W2411361269 @default.
- W3205038140 cites W2417483443 @default.
- W3205038140 cites W2541283511 @default.
- W3205038140 cites W2549858476 @default.
- W3205038140 cites W2604389567 @default.
- W3205038140 cites W2613543041 @default.
- W3205038140 cites W2619553685 @default.
- W3205038140 cites W2620721366 @default.
- W3205038140 cites W2772692099 @default.
- W3205038140 cites W2800392236 @default.
- W3205038140 cites W2802753517 @default.
- W3205038140 cites W2913468892 @default.
- W3205038140 cites W2924384775 @default.
- W3205038140 cites W2950549285 @default.
- W3205038140 cites W2978980575 @default.
- W3205038140 cites W2994852580 @default.
- W3205038140 cites W2999630643 @default.
- W3205038140 cites W3005233576 @default.
- W3205038140 cites W3007935255 @default.
- W3205038140 cites W3037482866 @default.
- W3205038140 cites W3046538729 @default.
- W3205038140 cites W3106188259 @default.
- W3205038140 cites W3122917998 @default.
- W3205038140 cites W3124296497 @default.
- W3205038140 cites W3128091223 @default.
- W3205038140 cites W3138699713 @default.
- W3205038140 cites W3161328221 @default.
- W3205038140 cites W3163061470 @default.
- W3205038140 cites W4232510995 @default.