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- W3205054037 abstract "A causal relationship between plasma ceramide concentration and respiratory distress symptoms in COVID-19 patients is inferred. In this study, plasma samples of 52 individuals infected with COVID-19 were utilized in a lipidomic analysis. Lipids belonging to the ceramide class exhibited a 400-fold increase in total plasma concentration in infected patients. Further analysis led to the demonstration of concentration dependency for severe COVID-19 respiratory symptoms in a subclass of ceramides. The subclasses Cer(d18:0/24:1), Cer(d18:1/24:1), and Cer(d18:1/22:0) were shown to be increased by 48-, 40-, and 33-fold, respectively, in infected plasma samples and to 116-, 91- and 50-fold, respectively, in plasma samples with respiratory distress. Hence, monitoring plasma ceramide concentration, can be a valuable tool for measuring effects of therapies on COVID-19 respiratory distress patients." @default.
- W3205054037 created "2021-10-25" @default.
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- W3205054037 date "2021-10-21" @default.
- W3205054037 modified "2023-10-18" @default.
- W3205054037 title "Inferring a causal relationship between ceramide levels and COVID-19 respiratory distress" @default.
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- W3205054037 doi "https://doi.org/10.1038/s41598-021-00286-7" @default.
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