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- W3205062512 endingPage "1473" @default.
- W3205062512 startingPage "1458" @default.
- W3205062512 abstract "Dairy cow subfertility is a worldwide issue arising from multiple factors. It manifests in >30% early pregnancy losses in seasonal pasture-grazed herds, especially when cows are inseminated in the early post-partum period. Most losses occur before implantation, when embryo growth depends on factors present in maternal tract fluids. Here we examined the proteomic composition of early and mid-postpartum uterine luminal fluid (ULF) in crossbred lactating dairy cows to identify molecular determinants of fertility. We also explored changes in ULF from first to third estrus cycles postpartum in individual cows, linking those changes with divergent embryo development. For this, we flushed uteri of 87 cows at Day 7 of pregnancy at first and third estrus postpartum, recovering, and grading their embryos. Out of 1563 proteins detected, 472 had not been previously reported in this fluid, and 408 were predicted to be actively secreted by bioinformatic analysis. The abundance of 18 proteins with roles in immune regulation and metabolic function (e.g. cystatin B, pyruvate kinase M2) was associated with contrasting embryo quality. Matched-paired pathway analysis indicated that, from first to third estrus postpartum, upregulation of metabolic (e.g. creatine and carbohydrate) and immune (e.g. complement regulation, antiviral defense) processes were related to poorer quality embryos in the third estrus cycle postpartum. Conversely, upregulated signal transduction and protein trafficking appeared related to improved embryo quality in third estrus. These results advance the characterization of the molecular environment of bovine ULF and may aid understanding fertility issues in other mammals, including humans." @default.
- W3205062512 created "2021-10-25" @default.
- W3205062512 creator A5020102380 @default.
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- W3205062512 creator A5034835188 @default.
- W3205062512 creator A5044009673 @default.
- W3205062512 creator A5073990749 @default.
- W3205062512 date "2021-10-14" @default.
- W3205062512 modified "2023-09-25" @default.
- W3205062512 title "Proteomic determinants of uterine receptivity for pregnancy in early and mid-postpartum dairy cows" @default.
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