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• W3205072178 startingPage "11174" @default.
• W3205072178 abstract "The selenoprotein family includes 25 members, many of which are antioxidant or redox regulating enzymes. A unique member of this family is Selenoprotein I (SELENOI), which does not catalyze redox reactions, but instead is an ethanolamine phosphotransferase (Ept). In fact, the characteristic selenocysteine residue that defines selenoproteins lies far outside of the catalytic domain of SELENOI. Furthermore, data using recombinant SELENOI lacking the selenocysteine residue have suggested that the selenocysteine amino acid is not directly involved in the Ept reaction. SELENOI is involved in two different pathways for the synthesis of phosphatidylethanolamine (PE) and plasmenyl PE, which are constituents of cellular membranes. Ethanolamine phospholipid synthesis has emerged as an important process for metabolic reprogramming that occurs in pluripotent stem cells and proliferating tumor cells, and this review discusses roles for upregulation of SELENOI during T cell activation, proliferation, and differentiation. SELENOI deficiency lowers but does not completely diminish de novo synthesis of PE and plasmenyl PE during T cell activation. Interestingly, metabolic reprogramming in activated SELENOI deficient T cells is impaired and this reduces proliferative capacity while favoring tolerogenic to pathogenic phenotypes that arise from differentiation. The implications of these findings are discussed related to vaccine responses, autoimmunity, and cell-based therapeutic approaches." @default.
• W3205072178 created "2021-10-25" @default.
• W3205072178 creator A5033498789 @default.
• W3205072178 creator A5039047253 @default.
• W3205072178 creator A5064225289 @default.
• W3205072178 date "2021-10-16" @default.
• W3205072178 modified "2023-09-30" @default.
• W3205072178 title "Roles for Selenoprotein I and Ethanolamine Phospholipid Synthesis in T Cell Activation" @default.
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• W3205072178 doi "https://doi.org/10.3390/ijms222011174" @default.
• W3205072178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8540796" @default.
• W3205072178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34681834" @default.
• W3205072178 hasPublicationYear "2021" @default.
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