Matches in SemOpenAlex for { <https://semopenalex.org/work/W3205111465> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W3205111465 abstract "Abstract Background High-sensitivity C-reactive protein (hsCRP) predicts major cardiovascular events (MACE) in patients with chronic atherosclerotic cardiovascular disease. The relationship between serial longitudinal hsCRP assessment and long-term MACE has not been explored. Purpose We tested the hypothesis that longitudinal follow-up hsCRP levels (repeated measures over time) would associate with 30-month MACE (cardiovascular death, myocardial infarction, cerebrovascular accident, coronary revascularization or hospitalization for unstable angina) rates. Methods We performed a post-hoc analysis of the ACCELERATE trial of optimally-treated patients with high-risk vascular disease and evaluated data from patients with available baseline and at least one follow-up hsCRP level measured at 3, 12, and 24 months. Those with a MACE event occurring before 3 months were omitted. Using multivariable Cox proportional hazard models, we determined the association of longitudinal follow-up hsCRP levels with MACE, its components, and all-cause mortality at 30-months, adjusting for age, race, sex, region, smoking status, body mass index, diabetes, baseline hsCRP, low density lipoprotein-cholesterol, high-density lipoprotein cholesterol, systolic blood pressure, statin use, and treatment group. Results Among 8,563 patients, mean age was 64.6±9.3 years and 22.2% were women. Median baseline hsCRP was 1.49 (0.74, 3.3) mg/L. Median time-weighted average follow-up hsCRP was 1.80 (0.88, 3.9) mg/L and mean time-weighted average follow-up LDL-C was 71.7±28.0 mg/dL. At 30 months, there was a significant stepwise relationship between cumulative MACE and increasing tertiles of last prior hsCRP value before an event or censoring (KM estimates for tertiles 1–3, respectively: 8.9 vs. 12.4 vs. 15.6%, p<0.001). In multivariable analysis, higher longitudinal follow-up hsCRP levels were independently associated with MACE [HR (95% CI) per SD: 1.19 (1.10, 1.29), p<0.001], all-cause death [1.66 (1.48, 1.86), p<0.001], cardiovascular death [1.39 (1.19, 1.62), p<0.001], myocardial infarction [1.28 (1.12, 1.46), p<0.001], stroke [1.32 (1.08, 1.62), p=0.007], and coronary revascularization [1.12 (1.01, 1.24), p=0.03], but not with hospitalization for unstable angina [0.94 (0.77, 1.14), p=0.51]. Longitudinal follow-up hsCRP was significantly associated with MACE in patients with baseline hsCRP <2mg/L [1.16 (1.04, 1.30), p=0.008] and ≥2mg/L [1.25 (1.12, 1.40), p<0.001]. Conclusions In the setting of established medical therapies, longitudinal follow-up hsCRP is significantly associated with an increased risk of long-term MACE, myocardial infarction, stroke, cardiovascular mortality, coronary revascularization, and all-cause death. Longitudinal follow-up hsCRP may thus represent a novel marker of residual cardiovascular risk, supporting further work exploring the potential diagnostic and therapeutic implications of these findings. FUNDunding Acknowledgement Type of funding sources: Foundation. Main funding source(s): Iryna Dykun was supported by the German Research Foundation" @default.
- W3205111465 created "2021-10-25" @default.
- W3205111465 creator A5008481106 @default.
- W3205111465 creator A5011091435 @default.
- W3205111465 creator A5040589473 @default.
- W3205111465 creator A5055849986 @default.
- W3205111465 creator A5062737940 @default.
- W3205111465 creator A5072488754 @default.
- W3205111465 creator A5082821169 @default.
- W3205111465 creator A5087247030 @default.
- W3205111465 date "2021-10-01" @default.
- W3205111465 modified "2023-09-27" @default.
- W3205111465 title "Longitudinal high-sensitivity C-reactive protein and long-term cardiovascular outcomes in optimally-treated patients with high-risk vascular disease" @default.
- W3205111465 doi "https://doi.org/10.1093/eurheartj/ehab724.2513" @default.
- W3205111465 hasPublicationYear "2021" @default.
- W3205111465 type Work @default.
- W3205111465 sameAs 3205111465 @default.
- W3205111465 citedByCount "0" @default.
- W3205111465 crossrefType "journal-article" @default.
- W3205111465 hasAuthorship W3205111465A5008481106 @default.
- W3205111465 hasAuthorship W3205111465A5011091435 @default.
- W3205111465 hasAuthorship W3205111465A5040589473 @default.
- W3205111465 hasAuthorship W3205111465A5055849986 @default.
- W3205111465 hasAuthorship W3205111465A5062737940 @default.
- W3205111465 hasAuthorship W3205111465A5072488754 @default.
- W3205111465 hasAuthorship W3205111465A5082821169 @default.
- W3205111465 hasAuthorship W3205111465A5087247030 @default.
- W3205111465 hasConcept C126322002 @default.
- W3205111465 hasConcept C164705383 @default.
- W3205111465 hasConcept C207103383 @default.
- W3205111465 hasConcept C2776914184 @default.
- W3205111465 hasConcept C2777785093 @default.
- W3205111465 hasConcept C2780221984 @default.
- W3205111465 hasConcept C2780400711 @default.
- W3205111465 hasConcept C2780739214 @default.
- W3205111465 hasConcept C2781195455 @default.
- W3205111465 hasConcept C44249647 @default.
- W3205111465 hasConcept C500558357 @default.
- W3205111465 hasConcept C50382708 @default.
- W3205111465 hasConcept C71924100 @default.
- W3205111465 hasConcept C84393581 @default.
- W3205111465 hasConceptScore W3205111465C126322002 @default.
- W3205111465 hasConceptScore W3205111465C164705383 @default.
- W3205111465 hasConceptScore W3205111465C207103383 @default.
- W3205111465 hasConceptScore W3205111465C2776914184 @default.
- W3205111465 hasConceptScore W3205111465C2777785093 @default.
- W3205111465 hasConceptScore W3205111465C2780221984 @default.
- W3205111465 hasConceptScore W3205111465C2780400711 @default.
- W3205111465 hasConceptScore W3205111465C2780739214 @default.
- W3205111465 hasConceptScore W3205111465C2781195455 @default.
- W3205111465 hasConceptScore W3205111465C44249647 @default.
- W3205111465 hasConceptScore W3205111465C500558357 @default.
- W3205111465 hasConceptScore W3205111465C50382708 @default.
- W3205111465 hasConceptScore W3205111465C71924100 @default.
- W3205111465 hasConceptScore W3205111465C84393581 @default.
- W3205111465 hasIssue "Supplement_1" @default.
- W3205111465 hasLocation W32051114651 @default.
- W3205111465 hasOpenAccess W3205111465 @default.
- W3205111465 hasPrimaryLocation W32051114651 @default.
- W3205111465 hasRelatedWork W1992696214 @default.
- W3205111465 hasRelatedWork W1999531413 @default.
- W3205111465 hasRelatedWork W2020050573 @default.
- W3205111465 hasRelatedWork W2049397185 @default.
- W3205111465 hasRelatedWork W2089715561 @default.
- W3205111465 hasRelatedWork W2382991963 @default.
- W3205111465 hasRelatedWork W3146182361 @default.
- W3205111465 hasRelatedWork W3165669502 @default.
- W3205111465 hasRelatedWork W4281253028 @default.
- W3205111465 hasRelatedWork W4304166097 @default.
- W3205111465 hasVolume "42" @default.
- W3205111465 isParatext "false" @default.
- W3205111465 isRetracted "false" @default.
- W3205111465 magId "3205111465" @default.
- W3205111465 workType "article" @default.