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- W3205155021 abstract "Abstract Ecteinascidin-743 (Trabectidin, Trabectedin ® , Yondelis ® ) is a synthetically obtained pharmaceutical drug originally isolated from a marine tunicate. Trabectedin is used for the chemotherapy of soft-tissue sarcoma and ovarian cancer. The isoquinolinium metabolite ETM-204 has been found in biotransformation and degradation studies of Trabectedin. We report the first total synthesis of ETM-204 and its full spectroscopic characterization confirming the postulated structure. Central elements of the 12-step synthesis starting from 2-methyl-6-nitrophenol are a Cu-mediated conversion of an iodoarene to a phenol, a Skattebøl-formylation, and a modified Pomeranz–Fritsch cyclization to assemble the isoquinoline ring. The pH-dependence of its visual absorbance could be clarified. Graphic abstract" @default.
- W3205155021 created "2021-10-25" @default.
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- W3205155021 date "2021-10-19" @default.
- W3205155021 modified "2023-10-15" @default.
- W3205155021 title "Total synthesis of the isoquinolinium metabolite ETM-204 of Trabectidin" @default.
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- W3205155021 doi "https://doi.org/10.1007/s00706-021-02844-1" @default.
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