FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3205167711> ?p ?o ?g. }

• W3205167711 abstract "Synchronization and bursting activity are intrinsic electrophysiological properties of in vivo and in vitro neural networks. During early development, cortical cultures exhibit a wide repertoire of synchronous bursting dynamics whose characterization may help to understand the parameters governing the transition from immature to mature networks. Here we used machine learning techniques to characterize and predict the developing spontaneous activity in mouse cortical neurons on microelectrode arrays (MEAs) during the first three weeks in vitro. Network activity at three stages of early development was defined by 18 electrophysiological features of spikes, bursts, synchrony, and connectivity. The variability of neuronal network activity during early development was investigated by applying k-means and self-organizing map (SOM) clustering analysis to features of bursts and synchrony. These electrophysiological features were predicted at the third week in vitro with high accuracy from those at earlier times using three machine learning models: Multivariate Adaptive Regression Splines, Support Vector Machines, and Random Forest. Our results indicate that initial patterns of electrical activity during the first week in vitro may already predetermine the final development of the neuronal network activity. The methodological approach used here may be applied to explore the biological mechanisms underlying the complex dynamics of spontaneous activity in developing neuronal cultures." @default.
• W3205167711 created "2021-10-25" @default.
• W3205167711 creator A5001040130 @default.
• W3205167711 creator A5001284489 @default.
• W3205167711 creator A5003062463 @default.
• W3205167711 creator A5034122674 @default.
• W3205167711 creator A5050543125 @default.
• W3205167711 creator A5072077240 @default.
• W3205167711 date "2021-10-14" @default.
• W3205167711 modified "2023-10-06" @default.
• W3205167711 title "Early prediction of developing spontaneous activity in cultured neuronal networks" @default.
• W3205167711 cites W1529448825 @default.
• W3205167711 cites W1976805317 @default.
• W3205167711 cites W1977019056 @default.
• W3205167711 cites W1987958715 @default.
• W3205167711 cites W1999653836 @default.
• W3205167711 cites W2017539895 @default.
• W3205167711 cites W2036435819 @default.
• W3205167711 cites W2045527633 @default.
• W3205167711 cites W2051013962 @default.
• W3205167711 cites W2064241002 @default.
• W3205167711 cites W2070340804 @default.
• W3205167711 cites W2074019524 @default.
• W3205167711 cites W2082249282 @default.
• W3205167711 cites W2083100423 @default.
• W3205167711 cites W2102297429 @default.
• W3205167711 cites W2104476748 @default.
• W3205167711 cites W2105445038 @default.
• W3205167711 cites W2105475977 @default.
• W3205167711 cites W2107123049 @default.
• W3205167711 cites W2110802877 @default.
• W3205167711 cites W2115632274 @default.
• W3205167711 cites W2115801392 @default.
• W3205167711 cites W2120204563 @default.
• W3205167711 cites W2120485883 @default.
• W3205167711 cites W2124354910 @default.
• W3205167711 cites W2142107686 @default.
• W3205167711 cites W2147918634 @default.
• W3205167711 cites W2148143831 @default.
• W3205167711 cites W2153947402 @default.
• W3205167711 cites W2155338866 @default.
• W3205167711 cites W2157586156 @default.
• W3205167711 cites W2167822639 @default.
• W3205167711 cites W2172274087 @default.
• W3205167711 cites W2175528441 @default.
• W3205167711 cites W2293324340 @default.
• W3205167711 cites W2332303179 @default.
• W3205167711 cites W2338149947 @default.
• W3205167711 cites W2344855436 @default.
• W3205167711 cites W2401629147 @default.
• W3205167711 cites W2543267583 @default.
• W3205167711 cites W2771169143 @default.
• W3205167711 cites W2785184350 @default.
• W3205167711 cites W2803718659 @default.
• W3205167711 cites W2901072521 @default.
• W3205167711 cites W2911964244 @default.
• W3205167711 cites W2946884482 @default.
• W3205167711 cites W2952121911 @default.
• W3205167711 cites W2954254309 @default.
• W3205167711 cites W2963119595 @default.
• W3205167711 cites W2965145684 @default.
• W3205167711 cites W2973696834 @default.
• W3205167711 cites W2990811301 @default.
• W3205167711 cites W2997657494 @default.
• W3205167711 cites W3046749939 @default.
• W3205167711 cites W3106438912 @default.
• W3205167711 cites W4241499463 @default.
• W3205167711 cites W65738273 @default.
• W3205167711 doi "https://doi.org/10.1038/s41598-021-99538-9" @default.
• W3205167711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8516856" @default.
• W3205167711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34650146" @default.
• W3205167711 hasPublicationYear "2021" @default.
• W3205167711 type Work @default.
• W3205167711 sameAs 3205167711 @default.
• W3205167711 citedByCount "10" @default.
• W3205167711 countsByYear W32051677112022 @default.
• W3205167711 countsByYear W32051677112023 @default.
• W3205167711 crossrefType "journal-article" @default.
• W3205167711 hasAuthorship W3205167711A5001040130 @default.
• W3205167711 hasAuthorship W3205167711A5001284489 @default.
• W3205167711 hasAuthorship W3205167711A5003062463 @default.
• W3205167711 hasAuthorship W3205167711A5034122674 @default.
• W3205167711 hasAuthorship W3205167711A5050543125 @default.
• W3205167711 hasAuthorship W3205167711A5072077240 @default.
• W3205167711 hasBestOaLocation W32051677111 @default.
• W3205167711 hasConcept C111670793 @default.
• W3205167711 hasConcept C121332964 @default.
• W3205167711 hasConcept C154945302 @default.
• W3205167711 hasConcept C169760540 @default.
• W3205167711 hasConcept C17525397 @default.
• W3205167711 hasConcept C185263204 @default.
• W3205167711 hasConcept C195221683 @default.
• W3205167711 hasConcept C2780196419 @default.
• W3205167711 hasConcept C41008148 @default.
• W3205167711 hasConcept C62520636 @default.
• W3205167711 hasConcept C74254510 @default.
• W3205167711 hasConcept C86803240 @default.
• W3205167711 hasConcept C95967509 @default.
• W3205167711 hasConceptScore W3205167711C111670793 @default.
• W3205167711 hasConceptScore W3205167711C121332964 @default.

• next