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- W3205219313 abstract "Natural products that inhibit cell cycle progression show promise as anticancer agents and chemical probes. In our research on biologically active natural products that affect cell cycle progression of HeLa/fluorescent ubiquitination-based cell cycle indicator (Fucci)2 cells, the extract of the marine sponge Neopetrosia chaliniformis was revealed to inhibit cell proliferation. Purification of the extract afforded four new pyridine alkaloids, neopetrosidines A–D (1–4). Their structures were elucidated by the interpretation of spectroscopic data and chemical degradation. Compounds 1–4 were found to inhibit cell proliferation of HeLa/Fucci2 cells, and time-lapse imaging showed that 1 exerts its effect by increasing the duration of the cell cycle. Furthermore, we show that 1 perturbs bioenergetics to exhibit a cytostatic effect by reducing the mitochondrial membrane potential." @default.
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- W3205219313 date "2021-11-01" @default.
- W3205219313 modified "2023-10-16" @default.
- W3205219313 title "Neopetrosidines A–D, pyridine alkaloids isolated from the marine sponge Neopetrosia chaliniformis and their cell cycle elongation activity" @default.
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- W3205219313 doi "https://doi.org/10.1016/j.bmc.2021.116461" @default.
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