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- W3205244870 abstract "Abstract The mechanistic events leading to alterations of DNA replication in normal and diseased cells remain unknown. The present study uncovers the role of a new class of non-coding RNAs induced in early S-phase, able to activate and repress replication origins formation. The discovery of a RNA-mediated mechanism governing the replication of c-MYC locus offers novel strategies to control DNA replication by modulating transcriptional activity, and pave the way for future clinical applications to treat cancer and genetic disorders." @default.
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- W3205244870 date "2021-10-20" @default.
- W3205244870 modified "2023-10-03" @default.
- W3205244870 title "S-phase induced RNAs initiate formation of DNA replication origins" @default.
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- W3205244870 doi "https://doi.org/10.1101/2021.10.19.465050" @default.
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