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• W3205247625 endingPage "1345" @default.
• W3205247625 startingPage "1338" @default.
• W3205247625 abstract "Radical-directed dissociation (RDD) is a powerful technique for structural characterization of peptides in mass spectrometry experiments. Prior to analysis, a radical precursor must typically be appended to facilitate generation of a free radical. To explore the use of a radical precursor that can be easily attached in a single step, we modified peptides using a “click” reaction with iodophenyl isothiocyanate. Coupling with amine functional groups proceeds with high yields, producing stable iodophenylthiourea-modified peptides. Photodissociation yields were recorded at 266 and 213 nm for the 2-, 3-, and 4-iodo isomers of the modifier and found to be highest for the 4-iodo isomer in nearly all cases. Fragmentation of the modified peptides following collisional activation revealed favorable losses of the tag, and electronic structure calculations were used to evaluate a potential mechanism involving hydrogen transfer within the thiourea group. Examination of RDD data revealed that 4-iodobenzoic acid, 4-iodophenylthiourea, and 3-iodotyrosine yield similar fragmentation patterns for a given peptide, although differences in fragment abundance are noted. Iodophenyl isothiocyanate labeling in combination with RDD can be used to differentiate isomeric amino acids within peptides, which should facilitate simplified evaluation of isomers present in complex biological samples." @default.
• W3205247625 created "2021-10-25" @default.
• W3205247625 creator A5023557796 @default.
• W3205247625 creator A5042739373 @default.
• W3205247625 date "2021-10-20" @default.
• W3205247625 modified "2023-09-26" @default.
• W3205247625 title "Efficient Isothiocyanate Modification of Peptides Facilitates Structural Analysis by Radical-Directed Dissociation" @default.
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• W3205247625 doi "https://doi.org/10.1021/jasms.1c00237" @default.
• W3205247625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34670075" @default.
• W3205247625 hasPublicationYear "2021" @default.
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