FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3205248519> ?p ?o ?g. }

• W3205248519 endingPage "806" @default.
• W3205248519 startingPage "796" @default.
• W3205248519 abstract "Parvalbumin (PV)-positive cells are strategic elements of neuronal networks capable of influencing memory and learning processes. However, it is not known whether pituitary hormones may be related to PV expression in the hippocampus - a part of the limbic system with important functions in learning and memory.Since previous studies indicate that prolactin (PRL) plays a significant role in hippocampal-dependent learning and synaptic plasticity, we hypothesized that a rise in PRL levels can modify PV expression in the hippocampus.We employed biochemical, immunohistochemistry, and densitometry techniques - as well as a behavioural assay - in a hyperprolactinemia model using subcutaneous osmotic pumps in female mice.PRL treatment via osmotic pump induced an increase in PRL receptor (PRLR) expression in most regions of the hippocampus analysed by Western blotting and immunohistochemistry methods. Fluorescent densitometry analysis revealed that PV expression decreases in the same layers in the hippocampus following PRL treatment, while double labelling immunostaining indicated close localization of PV and PRLR in PV-positive interneurons. In addition, we found that PRL induced a reduction in the β2/3 subunit of GABAA receptor (GABAAR) expression that was linearly correlated with the reduction in PV expression. This reduction in the β2/3 subunit of GABAAR expression was maintained in trained animals in which PRL treatment improved the learning of a spatial memory task.These data show, for the first time, that an increase in PRL level is associated with changes in key constituent elements of inhibitory circuits in the hippocampus and may be of relevance for the alterations in cognitive function reported in hyperprolactinemia." @default.
• W3205248519 created "2021-10-25" @default.
• W3205248519 creator A5008315119 @default.
• W3205248519 creator A5015904215 @default.
• W3205248519 creator A5033758787 @default.
• W3205248519 creator A5036041998 @default.
• W3205248519 creator A5085367073 @default.
• W3205248519 date "2021-10-19" @default.
• W3205248519 modified "2023-10-18" @default.
• W3205248519 title "Prolactin Reduces Hippocampal Parvalbumin and GABA_A Receptor Expression in Female Mice" @default.
• W3205248519 cites W1543985160 @default.
• W3205248519 cites W1975952480 @default.
• W3205248519 cites W1980123107 @default.
• W3205248519 cites W1990653946 @default.
• W3205248519 cites W1999251867 @default.
• W3205248519 cites W2007475689 @default.
• W3205248519 cites W2016321438 @default.
• W3205248519 cites W2016652516 @default.
• W3205248519 cites W2017169966 @default.
• W3205248519 cites W2019055295 @default.
• W3205248519 cites W2022378061 @default.
• W3205248519 cites W2026233193 @default.
• W3205248519 cites W2035696194 @default.
• W3205248519 cites W2047347093 @default.
• W3205248519 cites W2047403459 @default.
• W3205248519 cites W2049511526 @default.
• W3205248519 cites W2054521012 @default.
• W3205248519 cites W2069464803 @default.
• W3205248519 cites W2070626104 @default.
• W3205248519 cites W2072316582 @default.
• W3205248519 cites W2113103296 @default.
• W3205248519 cites W2119677102 @default.
• W3205248519 cites W2124793944 @default.
• W3205248519 cites W2130844101 @default.
• W3205248519 cites W2144531560 @default.
• W3205248519 cites W2157146316 @default.
• W3205248519 cites W2162666247 @default.
• W3205248519 cites W2164875032 @default.
• W3205248519 cites W2167916157 @default.
• W3205248519 cites W2263642492 @default.
• W3205248519 cites W2395911570 @default.
• W3205248519 cites W2604616981 @default.
• W3205248519 cites W2695501819 @default.
• W3205248519 cites W2758506046 @default.
• W3205248519 cites W2791836612 @default.
• W3205248519 cites W2799510659 @default.
• W3205248519 cites W2801036304 @default.
• W3205248519 cites W2904776885 @default.
• W3205248519 cites W2935902195 @default.
• W3205248519 cites W2996095329 @default.
• W3205248519 cites W3107213669 @default.
• W3205248519 cites W3112137146 @default.
• W3205248519 cites W3190155904 @default.
• W3205248519 cites W4211199751 @default.
• W3205248519 doi "https://doi.org/10.1159/000520279" @default.
• W3205248519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34666336" @default.
• W3205248519 hasPublicationYear "2021" @default.
• W3205248519 type Work @default.
• W3205248519 sameAs 3205248519 @default.
• W3205248519 citedByCount "1" @default.
• W3205248519 countsByYear W32052485192023 @default.
• W3205248519 crossrefType "journal-article" @default.
• W3205248519 hasAuthorship W3205248519A5008315119 @default.
• W3205248519 hasAuthorship W3205248519A5015904215 @default.
• W3205248519 hasAuthorship W3205248519A5033758787 @default.
• W3205248519 hasAuthorship W3205248519A5036041998 @default.
• W3205248519 hasAuthorship W3205248519A5085367073 @default.
• W3205248519 hasBestOaLocation W32052485191 @default.
• W3205248519 hasConcept C126322002 @default.
• W3205248519 hasConcept C134018914 @default.
• W3205248519 hasConcept C141547260 @default.
• W3205248519 hasConcept C148762608 @default.
• W3205248519 hasConcept C168258287 @default.
• W3205248519 hasConcept C169760540 @default.
• W3205248519 hasConcept C170493617 @default.
• W3205248519 hasConcept C185592680 @default.
• W3205248519 hasConcept C2776464000 @default.
• W3205248519 hasConcept C2779064019 @default.
• W3205248519 hasConcept C2781161787 @default.
• W3205248519 hasConcept C71315377 @default.
• W3205248519 hasConcept C71924100 @default.
• W3205248519 hasConcept C86803240 @default.
• W3205248519 hasConceptScore W3205248519C126322002 @default.
• W3205248519 hasConceptScore W3205248519C134018914 @default.
• W3205248519 hasConceptScore W3205248519C141547260 @default.
• W3205248519 hasConceptScore W3205248519C148762608 @default.
• W3205248519 hasConceptScore W3205248519C168258287 @default.
• W3205248519 hasConceptScore W3205248519C169760540 @default.
• W3205248519 hasConceptScore W3205248519C170493617 @default.
• W3205248519 hasConceptScore W3205248519C185592680 @default.
• W3205248519 hasConceptScore W3205248519C2776464000 @default.
• W3205248519 hasConceptScore W3205248519C2779064019 @default.
• W3205248519 hasConceptScore W3205248519C2781161787 @default.
• W3205248519 hasConceptScore W3205248519C71315377 @default.
• W3205248519 hasConceptScore W3205248519C71924100 @default.
• W3205248519 hasConceptScore W3205248519C86803240 @default.
• W3205248519 hasIssue "8" @default.
• W3205248519 hasLocation W32052485191 @default.

• next