Matches in SemOpenAlex for { <https://semopenalex.org/work/W3205277926> ?p ?o ?g. }
- W3205277926 endingPage "1545" @default.
- W3205277926 startingPage "1538" @default.
- W3205277926 abstract "To investigate the potential anti-breast cancer activity of zerumbone in regulating apoptotic mediators and cytokines in comparison with paclitaxel (positive control).In this study, assays such as viability, apoptosis, reactive oxygen species, cell cycle, DNA fragmentation, and cytokines were carried out on MCF-7 cells after treatment with zerumbone and paclitaxel.The results showed that zerumbone demonstrated a higher (18-fold) IC50 value (126.7 µg/ml) than paclitaxel (7.29 µg/ml) in order to suppress proliferation and induce cell death of MCF-7. The cell cycle arrest at the G0/G1 phase and excessive intracellular ROS production during the in vitro zerumbone treatment indicated occurrence of apoptotic cell death although nuclear DNA fragmentation was not observed. The flow cytometer analysis of treated cells revealed secretion of proinflammatory cytokines suggesting the potential immunomodulatory activity of zerumbone.Although, zerumbone exhibited a higher IC50 value compared with paclitaxel yet its anticancer activity against MCF-7 cells is still parallel to paclitaxel hence zerumbone has the potential to be an antineoplastic agent in the treatment of breast cancer especially the luminal type A." @default.
- W3205277926 created "2021-10-25" @default.
- W3205277926 creator A5024117835 @default.
- W3205277926 creator A5034281726 @default.
- W3205277926 creator A5046793884 @default.
- W3205277926 creator A5053889059 @default.
- W3205277926 creator A5055118153 @default.
- W3205277926 creator A5080118423 @default.
- W3205277926 date "2021-11-01" @default.
- W3205277926 modified "2023-09-27" @default.
- W3205277926 title "Zerumbone mediates apoptosis and induces secretion of proinflammatory cytokines in breast carcinoma cell culture." @default.
- W3205277926 cites W1954774358 @default.
- W3205277926 cites W1968295892 @default.
- W3205277926 cites W1976599392 @default.
- W3205277926 cites W2008757142 @default.
- W3205277926 cites W2010241704 @default.
- W3205277926 cites W2014392759 @default.
- W3205277926 cites W2037382204 @default.
- W3205277926 cites W2037679360 @default.
- W3205277926 cites W2041140495 @default.
- W3205277926 cites W2051930121 @default.
- W3205277926 cites W2078862204 @default.
- W3205277926 cites W2085138770 @default.
- W3205277926 cites W2102897174 @default.
- W3205277926 cites W2110361622 @default.
- W3205277926 cites W2121121796 @default.
- W3205277926 cites W2124173308 @default.
- W3205277926 cites W2149399725 @default.
- W3205277926 cites W2150937729 @default.
- W3205277926 cites W2154747925 @default.
- W3205277926 cites W2158716053 @default.
- W3205277926 cites W2274754252 @default.
- W3205277926 cites W2317055602 @default.
- W3205277926 cites W2325707043 @default.
- W3205277926 cites W2595346203 @default.
- W3205277926 cites W2620241325 @default.
- W3205277926 cites W2673032869 @default.
- W3205277926 cites W2726959413 @default.
- W3205277926 cites W2760634636 @default.
- W3205277926 cites W2767900770 @default.
- W3205277926 cites W2789306186 @default.
- W3205277926 cites W2789342623 @default.
- W3205277926 cites W2790967116 @default.
- W3205277926 cites W2802528458 @default.
- W3205277926 cites W2807500538 @default.
- W3205277926 cites W2811485525 @default.
- W3205277926 cites W2900960361 @default.
- W3205277926 cites W2914885691 @default.
- W3205277926 cites W2917058676 @default.
- W3205277926 cites W2921753789 @default.
- W3205277926 cites W2950071015 @default.
- W3205277926 cites W2958846431 @default.
- W3205277926 cites W2964650211 @default.
- W3205277926 cites W3021120812 @default.
- W3205277926 cites W3091014886 @default.
- W3205277926 cites W3110830766 @default.
- W3205277926 cites W3118804670 @default.
- W3205277926 cites W3128646645 @default.
- W3205277926 doi "https://doi.org/10.22038/ijbms.2021.58573.13012" @default.
- W3205277926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35317109" @default.
- W3205277926 hasPublicationYear "2021" @default.
- W3205277926 type Work @default.
- W3205277926 sameAs 3205277926 @default.
- W3205277926 citedByCount "0" @default.
- W3205277926 crossrefType "journal-article" @default.
- W3205277926 hasAuthorship W3205277926A5024117835 @default.
- W3205277926 hasAuthorship W3205277926A5034281726 @default.
- W3205277926 hasAuthorship W3205277926A5046793884 @default.
- W3205277926 hasAuthorship W3205277926A5053889059 @default.
- W3205277926 hasAuthorship W3205277926A5055118153 @default.
- W3205277926 hasAuthorship W3205277926A5080118423 @default.
- W3205277926 hasConcept C105696609 @default.
- W3205277926 hasConcept C109541995 @default.
- W3205277926 hasConcept C121608353 @default.
- W3205277926 hasConcept C126322002 @default.
- W3205277926 hasConcept C164027704 @default.
- W3205277926 hasConcept C185592680 @default.
- W3205277926 hasConcept C190283241 @default.
- W3205277926 hasConcept C203014093 @default.
- W3205277926 hasConcept C2776914184 @default.
- W3205277926 hasConcept C2777292972 @default.
- W3205277926 hasConcept C29537977 @default.
- W3205277926 hasConcept C2994423619 @default.
- W3205277926 hasConcept C31573885 @default.
- W3205277926 hasConcept C43759708 @default.
- W3205277926 hasConcept C49039625 @default.
- W3205277926 hasConcept C502942594 @default.
- W3205277926 hasConcept C55493867 @default.
- W3205277926 hasConcept C71924100 @default.
- W3205277926 hasConcept C86803240 @default.
- W3205277926 hasConcept C96232424 @default.
- W3205277926 hasConcept C98274493 @default.
- W3205277926 hasConceptScore W3205277926C105696609 @default.
- W3205277926 hasConceptScore W3205277926C109541995 @default.
- W3205277926 hasConceptScore W3205277926C121608353 @default.
- W3205277926 hasConceptScore W3205277926C126322002 @default.
- W3205277926 hasConceptScore W3205277926C164027704 @default.
- W3205277926 hasConceptScore W3205277926C185592680 @default.