Matches in SemOpenAlex for { <https://semopenalex.org/work/W3205281520> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W3205281520 abstract "The sole output of the eye are the retinal ganglion cells (RGCs) that project into multiple brain nuclei via the optic nerve (ON). A key choice point for RGC axons is to decussate at the midline to project either ipsi-laterally or contra-laterally. The first aim of this thesis is to evaluate whether the narrow set of molecules regulating RGC decussation is evolutionarily conserved. Secondly, we strive for a finer understanding of specific axon guidance molecules by using conditional mutant mice. To this end, we design a novel clearing tool (EyeDISCO) to access the entire visual system in three dimensions, from the eyes to the brain proper. First, we uncover that ipsi-lateral retinal projections (IRPs) are present in the first ray-finned fish as well as lobe-finned fish. These results suggest that IRPs most likely emerged in the common vertebrate ancestor. We further show that the molecular program orchestrating IRPs is not evolutionarily conserved in a ray-finned species. This hints at the fundamental idea that other cues may be responsible for the guidance of IRPs. Second, we shed light on the role of Dcc/Netrin-1 in RGC projections of mice. Remarkably, while a significant subset of RGC axons are unable to project into the ON, we reveal that a large population of RGCs still manages to project correctly in the absence of Dcc and Netrin-1. This heterogeneity underlines the probable interplay of multiple other, still undiscovered, guidance cues. Together, our work proposes a more complex model for RGC targeting across species and warrants future studies to take on an evolutionary perspective to better understand the fundamental mechanism at play during axon guidance." @default.
- W3205281520 created "2021-10-25" @default.
- W3205281520 creator A5032245159 @default.
- W3205281520 date "2020-09-28" @default.
- W3205281520 modified "2023-09-27" @default.
- W3205281520 title "Diversity of visual projections in vertebrates" @default.
- W3205281520 hasPublicationYear "2020" @default.
- W3205281520 type Work @default.
- W3205281520 sameAs 3205281520 @default.
- W3205281520 citedByCount "0" @default.
- W3205281520 crossrefType "dissertation" @default.
- W3205281520 hasAuthorship W3205281520A5032245159 @default.
- W3205281520 hasConcept C127955056 @default.
- W3205281520 hasConcept C144024400 @default.
- W3205281520 hasConcept C149923435 @default.
- W3205281520 hasConcept C169760540 @default.
- W3205281520 hasConcept C177264268 @default.
- W3205281520 hasConcept C199360897 @default.
- W3205281520 hasConcept C2777093970 @default.
- W3205281520 hasConcept C2777624874 @default.
- W3205281520 hasConcept C2778659636 @default.
- W3205281520 hasConcept C2779530196 @default.
- W3205281520 hasConcept C2779797997 @default.
- W3205281520 hasConcept C2780837183 @default.
- W3205281520 hasConcept C2908647359 @default.
- W3205281520 hasConcept C41008148 @default.
- W3205281520 hasConcept C69125201 @default.
- W3205281520 hasConcept C78458016 @default.
- W3205281520 hasConcept C86803240 @default.
- W3205281520 hasConceptScore W3205281520C127955056 @default.
- W3205281520 hasConceptScore W3205281520C144024400 @default.
- W3205281520 hasConceptScore W3205281520C149923435 @default.
- W3205281520 hasConceptScore W3205281520C169760540 @default.
- W3205281520 hasConceptScore W3205281520C177264268 @default.
- W3205281520 hasConceptScore W3205281520C199360897 @default.
- W3205281520 hasConceptScore W3205281520C2777093970 @default.
- W3205281520 hasConceptScore W3205281520C2777624874 @default.
- W3205281520 hasConceptScore W3205281520C2778659636 @default.
- W3205281520 hasConceptScore W3205281520C2779530196 @default.
- W3205281520 hasConceptScore W3205281520C2779797997 @default.
- W3205281520 hasConceptScore W3205281520C2780837183 @default.
- W3205281520 hasConceptScore W3205281520C2908647359 @default.
- W3205281520 hasConceptScore W3205281520C41008148 @default.
- W3205281520 hasConceptScore W3205281520C69125201 @default.
- W3205281520 hasConceptScore W3205281520C78458016 @default.
- W3205281520 hasConceptScore W3205281520C86803240 @default.
- W3205281520 hasLocation W32052815201 @default.
- W3205281520 hasOpenAccess W3205281520 @default.
- W3205281520 hasPrimaryLocation W32052815201 @default.
- W3205281520 hasRelatedWork W1147327437 @default.
- W3205281520 hasRelatedWork W1980257381 @default.
- W3205281520 hasRelatedWork W2006939786 @default.
- W3205281520 hasRelatedWork W2023416141 @default.
- W3205281520 hasRelatedWork W2026050820 @default.
- W3205281520 hasRelatedWork W2029279488 @default.
- W3205281520 hasRelatedWork W2063997169 @default.
- W3205281520 hasRelatedWork W2098827723 @default.
- W3205281520 hasRelatedWork W2160406987 @default.
- W3205281520 hasRelatedWork W2498743285 @default.
- W3205281520 hasRelatedWork W25499442 @default.
- W3205281520 hasRelatedWork W2742488714 @default.
- W3205281520 hasRelatedWork W2770690804 @default.
- W3205281520 hasRelatedWork W2800550141 @default.
- W3205281520 hasRelatedWork W2827510129 @default.
- W3205281520 hasRelatedWork W2924641346 @default.
- W3205281520 hasRelatedWork W3024657574 @default.
- W3205281520 hasRelatedWork W3124719857 @default.
- W3205281520 hasRelatedWork W46241006 @default.
- W3205281520 hasRelatedWork W61171989 @default.
- W3205281520 isParatext "false" @default.
- W3205281520 isRetracted "false" @default.
- W3205281520 magId "3205281520" @default.
- W3205281520 workType "dissertation" @default.