Matches in SemOpenAlex for { <https://semopenalex.org/work/W3205308001> ?p ?o ?g. }
- W3205308001 abstract "Abstract Serine/Arginine-Rich Splicing Factor 7 (SRSF7), which is previously recognized as a splicing factor, has been revealed to play oncogenic roles in multiple cancers. However, the mechanisms underlying its oncogenic roles have not been well addressed. Here, based on N6-methyladenosine (m 6 A) co-methylation network analysis across diverse cell lines, we found SRSF7 positively correlated with glioblastoma cell-specific m 6 A methylation. We then proved SRSF7 is a novel m 6 A regulator that specifically facilitates the m 6 A methylation near its binding sites on the mRNAs involved in cell proliferation and migration through recruiting methyltransferase complex. Moreover, SRSF7 promotes the proliferation and migration of glioblastoma cells largely dependent on the m 6 A methyltransferase. The two single-nucleotide m 6 A sites on PBK are regulated by SRSF7 and partially mediate the effects of SRSF7 on glioblastoma cells through recognition by IGF2BP2. Together, our discovery revealed a novel role of SRSF7 in regulating m 6 A and timely confirmed the existence and functional importance of RNA binding protein (RBP) mediated specific regulation of m 6 A." @default.
- W3205308001 created "2021-10-25" @default.
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- W3205308001 date "2021-10-11" @default.
- W3205308001 modified "2023-09-28" @default.
- W3205308001 title "Serine/arginine-rich splicing factor 7 plays oncogenic roles through specific regulation of m6A RNA modification" @default.
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