Matches in SemOpenAlex for { <https://semopenalex.org/work/W3205311345> ?p ?o ?g. }
- W3205311345 endingPage "195" @default.
- W3205311345 startingPage "173" @default.
- W3205311345 abstract "Microglia cells are active players in regulating synaptic development and plasticity in the brain. However, how they influence the normal functioning of synapses is largely unknown. In this study, we characterized the effects of pharmacological microglia depletion, achieved by administration of PLX5622, on hippocampal CA3-CA1 synapses of adult wild type mice. Following microglial depletion, we observed a reduction of spontaneous and evoked glutamatergic activity associated with a decrease of dendritic spine density. We also observed the appearance of immature synaptic features and higher levels of plasticity. Microglia depleted mice showed a deficit in the acquisition of the Novel Object Recognition task. These events were accompanied by hippocampal astrogliosis, although in the absence ofneuroinflammatory condition. PLX-induced synaptic changes were absent in Cx3cr1-/- mice, highlighting the role of CX3CL1/CX3CR1 axis in microglia control of synaptic functioning. Remarkably, microglia repopulation after PLX5622 withdrawal was associated with the recovery of hippocampal synapses and learning functions. Altogether, these data demonstrate that microglia contribute to normal synaptic functioning in the adult brain and that their removal induces reversible changes in organization and activity of glutamatergic synapses." @default.
- W3205311345 created "2021-10-25" @default.
- W3205311345 creator A5000640278 @default.
- W3205311345 creator A5002400884 @default.
- W3205311345 creator A5005172269 @default.
- W3205311345 creator A5007553002 @default.
- W3205311345 creator A5008701657 @default.
- W3205311345 creator A5008789500 @default.
- W3205311345 creator A5010995692 @default.
- W3205311345 creator A5021223799 @default.
- W3205311345 creator A5021435286 @default.
- W3205311345 creator A5023161302 @default.
- W3205311345 creator A5024593469 @default.
- W3205311345 creator A5028028069 @default.
- W3205311345 creator A5035936838 @default.
- W3205311345 creator A5039610838 @default.
- W3205311345 creator A5047316024 @default.
- W3205311345 creator A5047489586 @default.
- W3205311345 creator A5057102319 @default.
- W3205311345 creator A5060578164 @default.
- W3205311345 creator A5061166248 @default.
- W3205311345 creator A5062444844 @default.
- W3205311345 creator A5065401101 @default.
- W3205311345 creator A5066557231 @default.
- W3205311345 creator A5067223813 @default.
- W3205311345 creator A5074251872 @default.
- W3205311345 creator A5075967708 @default.
- W3205311345 creator A5081860121 @default.
- W3205311345 creator A5086494201 @default.
- W3205311345 creator A5089835851 @default.
- W3205311345 creator A5091068908 @default.
- W3205311345 date "2021-10-18" @default.
- W3205311345 modified "2023-10-16" @default.
- W3205311345 title "Microglia control glutamatergic synapses in the adult mouse hippocampus" @default.
- W3205311345 cites W1258429216 @default.
- W3205311345 cites W1544320664 @default.
- W3205311345 cites W1571745125 @default.
- W3205311345 cites W1593600686 @default.
- W3205311345 cites W1920357305 @default.
- W3205311345 cites W1955943544 @default.
- W3205311345 cites W1968024448 @default.
- W3205311345 cites W1970992446 @default.
- W3205311345 cites W1980789245 @default.
- W3205311345 cites W1981142987 @default.
- W3205311345 cites W1986281170 @default.
- W3205311345 cites W1996055705 @default.
- W3205311345 cites W1997497060 @default.
- W3205311345 cites W2003493421 @default.
- W3205311345 cites W2005933589 @default.
- W3205311345 cites W2008986835 @default.
- W3205311345 cites W2010609802 @default.
- W3205311345 cites W2011209444 @default.
- W3205311345 cites W2012010559 @default.
- W3205311345 cites W2019016101 @default.
- W3205311345 cites W2022767998 @default.
- W3205311345 cites W2025498751 @default.
- W3205311345 cites W2033617297 @default.
- W3205311345 cites W2035325710 @default.
- W3205311345 cites W2038813826 @default.
- W3205311345 cites W2044202654 @default.
- W3205311345 cites W2046922635 @default.
- W3205311345 cites W2054675346 @default.
- W3205311345 cites W2060915232 @default.
- W3205311345 cites W2062564051 @default.
- W3205311345 cites W2065393542 @default.
- W3205311345 cites W2066943555 @default.
- W3205311345 cites W2078690243 @default.
- W3205311345 cites W2087321410 @default.
- W3205311345 cites W2095551600 @default.
- W3205311345 cites W2096500024 @default.
- W3205311345 cites W2099005297 @default.
- W3205311345 cites W2104431737 @default.
- W3205311345 cites W2108891955 @default.
- W3205311345 cites W2113107925 @default.
- W3205311345 cites W2114570899 @default.
- W3205311345 cites W2120911948 @default.
- W3205311345 cites W2121085475 @default.
- W3205311345 cites W2125236750 @default.
- W3205311345 cites W2127381922 @default.
- W3205311345 cites W2137979527 @default.
- W3205311345 cites W2148389554 @default.
- W3205311345 cites W2151241903 @default.
- W3205311345 cites W2152712045 @default.
- W3205311345 cites W2163751922 @default.
- W3205311345 cites W2167022467 @default.
- W3205311345 cites W2169700519 @default.
- W3205311345 cites W2171785899 @default.
- W3205311345 cites W2192281019 @default.
- W3205311345 cites W2252088905 @default.
- W3205311345 cites W2256955303 @default.
- W3205311345 cites W2346538481 @default.
- W3205311345 cites W2522591839 @default.
- W3205311345 cites W2572710398 @default.
- W3205311345 cites W2791700208 @default.
- W3205311345 cites W2792302958 @default.
- W3205311345 cites W2893505137 @default.
- W3205311345 cites W2894787694 @default.
- W3205311345 cites W2897353323 @default.