Matches in SemOpenAlex for { <https://semopenalex.org/work/W3205356921> ?p ?o ?g. }
- W3205356921 endingPage "n/a" @default.
- W3205356921 startingPage "n/a" @default.
- W3205356921 abstract "PTEN is a dual-specificity phosphatase and well-known tumor suppressor gene. When functioning properly, it works in its canonical pathway to inhibit AKT/mTOR and MAPK signaling, leading to cell death and growth regulation. PTEN mutations cause dysregulation of these pathways, resulting in cellular proliferation and overgrowth. When germline mutations are present as in patients with PTEN Hamartoma Tumor Syndrome (PHTS), benign and malignant neoplasias occur as well as cerebral overgrowth and neurodevelopmental abnormalities. This review article will summarize recent laboratory and clinical investigations relating to PTEN, highlighting the overgrowth aspects of this syndrome and the molecular drivers behind these key phenotypes. Finally, therapies developed targeted the PI3K/AKT/mTOR pathway for other tumor predisposition syndromes will be discussed. © 2013 Wiley Periodicals, Inc." @default.
- W3205356921 created "2021-10-25" @default.
- W3205356921 creator A5053279930 @default.
- W3205356921 creator A5085761300 @default.
- W3205356921 date "2013-04-01" @default.
- W3205356921 modified "2023-09-26" @default.
- W3205356921 title "When Overgrowth Bumps Into Cancer: The PTEN-Opathies" @default.
- W3205356921 cites W1489145507 @default.
- W3205356921 cites W1973591203 @default.
- W3205356921 cites W1974900259 @default.
- W3205356921 cites W1977416006 @default.
- W3205356921 cites W1980269984 @default.
- W3205356921 cites W1984894895 @default.
- W3205356921 cites W1988609792 @default.
- W3205356921 cites W1990278643 @default.
- W3205356921 cites W1997649361 @default.
- W3205356921 cites W1998038367 @default.
- W3205356921 cites W2006890919 @default.
- W3205356921 cites W2015007646 @default.
- W3205356921 cites W2015232131 @default.
- W3205356921 cites W2019017173 @default.
- W3205356921 cites W2029938976 @default.
- W3205356921 cites W2033783187 @default.
- W3205356921 cites W2039501678 @default.
- W3205356921 cites W2040218616 @default.
- W3205356921 cites W2044095570 @default.
- W3205356921 cites W2047674796 @default.
- W3205356921 cites W2049041885 @default.
- W3205356921 cites W2053486980 @default.
- W3205356921 cites W2056004552 @default.
- W3205356921 cites W2060387248 @default.
- W3205356921 cites W2063437420 @default.
- W3205356921 cites W2065827515 @default.
- W3205356921 cites W2068025786 @default.
- W3205356921 cites W2068345721 @default.
- W3205356921 cites W2068427129 @default.
- W3205356921 cites W2084151879 @default.
- W3205356921 cites W2087812126 @default.
- W3205356921 cites W2089193884 @default.
- W3205356921 cites W2089354038 @default.
- W3205356921 cites W2094667242 @default.
- W3205356921 cites W2094941511 @default.
- W3205356921 cites W2102648794 @default.
- W3205356921 cites W2102837197 @default.
- W3205356921 cites W2107158827 @default.
- W3205356921 cites W2110452000 @default.
- W3205356921 cites W2110638436 @default.
- W3205356921 cites W2111062014 @default.
- W3205356921 cites W2116552110 @default.
- W3205356921 cites W2121186684 @default.
- W3205356921 cites W2121776570 @default.
- W3205356921 cites W2122230708 @default.
- W3205356921 cites W2130661390 @default.
- W3205356921 cites W2134749898 @default.
- W3205356921 cites W2147114673 @default.
- W3205356921 cites W2147941657 @default.
- W3205356921 cites W2150233389 @default.
- W3205356921 cites W2151308486 @default.
- W3205356921 cites W2161810908 @default.
- W3205356921 cites W2163685432 @default.
- W3205356921 cites W2165516672 @default.
- W3205356921 cites W2168231175 @default.
- W3205356921 cites W2168582583 @default.
- W3205356921 cites W2222586063 @default.
- W3205356921 cites W2383259826 @default.
- W3205356921 cites W4241102102 @default.
- W3205356921 cites W4253454796 @default.
- W3205356921 doi "https://doi.org/10.1002/j.1552-4876.2013.31364.x" @default.
- W3205356921 hasPublicationYear "2013" @default.
- W3205356921 type Work @default.
- W3205356921 sameAs 3205356921 @default.
- W3205356921 citedByCount "1" @default.
- W3205356921 countsByYear W32053569212014 @default.
- W3205356921 crossrefType "journal-article" @default.
- W3205356921 hasAuthorship W3205356921A5053279930 @default.
- W3205356921 hasAuthorship W3205356921A5085761300 @default.
- W3205356921 hasConcept C104317684 @default.
- W3205356921 hasConcept C121608353 @default.
- W3205356921 hasConcept C126322002 @default.
- W3205356921 hasConcept C127716648 @default.
- W3205356921 hasConcept C2777609662 @default.
- W3205356921 hasConcept C2778264664 @default.
- W3205356921 hasConcept C2780846426 @default.
- W3205356921 hasConcept C502942594 @default.
- W3205356921 hasConcept C54355233 @default.
- W3205356921 hasConcept C555283112 @default.
- W3205356921 hasConcept C60644358 @default.
- W3205356921 hasConcept C62478195 @default.
- W3205356921 hasConcept C71924100 @default.
- W3205356921 hasConcept C75217442 @default.
- W3205356921 hasConcept C86554907 @default.
- W3205356921 hasConcept C86803240 @default.
- W3205356921 hasConceptScore W3205356921C104317684 @default.
- W3205356921 hasConceptScore W3205356921C121608353 @default.
- W3205356921 hasConceptScore W3205356921C126322002 @default.
- W3205356921 hasConceptScore W3205356921C127716648 @default.
- W3205356921 hasConceptScore W3205356921C2777609662 @default.
- W3205356921 hasConceptScore W3205356921C2778264664 @default.