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- W3205361831 abstract "Tumour cell necrosis is one of the histopathological characteristics of a uterine sarcoma. On ultrasound, the features used to define central necrosis are often unclear, reflecting the diversity of its presentation. Central necrosis is here defined as an irregular mostly hyperechogenic avascular area with or without a central cystic area with irregular borders, within a moderate to highly vascularised solid mass. This is a retrospective descriptive monocentric study with inclusion of uterine sarcomas and benign leiomyomas, diagnosed at the University Hospital of Leuven between 2010-2019 and 2016-2019 respectively. Preoperative ultrasound images were assessed by two independent ultrasound examiners, blinded for the histology results. We identified 15 uterine sarcomas which were compared to 31 benign leiomyomas. Median age in the group of uterine sarcomas was 64 years (35-80 years), versus 45 years (36-54 years) for the leiomyoma group. 8/15 uterine sarcomas were diagnosed in FIGO stage I. Of the 15 uterine sarcomas, most were leiomyosarcomas (6/15). Central necrosis was detected on ultrasound by both observers in 60 and 73% of the uterine sarcoma cases respectively as compared to 13 and 13% in the benign leiomyoma group respectively. The interobserver agreement for the presence of central necrosis between the two ultrasound examiners was 57,6%. Central necrosis was visible on ultrasound in most uterine sarcomas and only in a minority of benign leiomyomas. Therefore, this feature may prove to be a good marker to use in ultrasound diagnosis. Besides the retrospective study design, the use of still images is an evident limitation of this study and is reflected by the low interobserver agreement. A strict description of the typical ultrasound features of central necrosis using real-time 2D- and 3D-ultrasonography with power Doppler imaging may improve the detection of high-risk cases. This should be assessed in a prospective trial comparing the typical ultrasound features of central necrosis in myometrial lesions with histopathology." @default.
- W3205361831 created "2021-10-25" @default.
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- W3205361831 date "2021-10-01" @default.
- W3205361831 modified "2023-09-26" @default.
- W3205361831 title "OC09.01: “Central necrosis”: a key sign in the sonographic diagnosis of uterine sarcomas?" @default.
- W3205361831 doi "https://doi.org/10.1002/uog.23841" @default.
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