Matches in SemOpenAlex for { <https://semopenalex.org/work/W3205379013> ?p ?o ?g. }
- W3205379013 abstract "Eukaryotic initiation factor 2A (eIF2A) is a 65 kDa protein that functions in minor initiation pathways, which affect the translation of only a subset of messenger ribonucleic acid (mRNAs), such as internal ribosome entry site (IRES)-containing mRNAs and/or mRNAs harboring upstream near cognate/non-AUG start codons. These non-canonical initiation events are important for regulation of protein synthesis during cellular development and/or the integrated stress response. Selective eIF2A knockdown in cellular systems significantly inhibits translation of such mRNAs, which rely on alternative initiation mechanisms for their translation. However, there exists a gap in our understanding of how eIF2A functions in mammalian systems in vivo (on the organismal level) and ex vivo (in cells). Here, using an eIF2A-knockout (KO) mouse model, we present evidence implicating eIF2A in the biology of aging, metabolic syndrome and central tolerance. We discovered that eIF2A-KO mice have reduced life span and that eIF2A plays an important role in maintenance of lipid homeostasis, the control of glucose tolerance, insulin resistance and also reduces the abundance of B lymphocytes and dendritic cells in the thymic medulla of mice. We also show the eIF2A KO affects male and female mice differently, suggesting that eIF2A may affect sex-specific pathways. Interestingly, our experiments involving pharmacological induction of endoplasmic reticulum (ER) stress with tunicamycin did not reveal any substantial difference between the response to ER stress in eIF2A-KO and wild-type mice. The identification of eIF2A function in the development of metabolic syndrome bears promise for the further identification of specific eIF2A targets responsible for these changes." @default.
- W3205379013 created "2021-10-25" @default.
- W3205379013 creator A5023344939 @default.
- W3205379013 creator A5025432010 @default.
- W3205379013 creator A5026152469 @default.
- W3205379013 creator A5035546319 @default.
- W3205379013 creator A5039598060 @default.
- W3205379013 creator A5041015307 @default.
- W3205379013 creator A5045610551 @default.
- W3205379013 creator A5054205591 @default.
- W3205379013 creator A5058869043 @default.
- W3205379013 creator A5059695318 @default.
- W3205379013 creator A5068619002 @default.
- W3205379013 creator A5072725425 @default.
- W3205379013 creator A5074403771 @default.
- W3205379013 creator A5075956912 @default.
- W3205379013 date "2021-10-19" @default.
- W3205379013 modified "2023-10-18" @default.
- W3205379013 title "eIF2A‐knockout mice reveal decreased life span and metabolic syndrome" @default.
- W3205379013 cites W11753821 @default.
- W3205379013 cites W1495096570 @default.
- W3205379013 cites W1541999139 @default.
- W3205379013 cites W182607020 @default.
- W3205379013 cites W1887169756 @default.
- W3205379013 cites W1898640512 @default.
- W3205379013 cites W1918892711 @default.
- W3205379013 cites W1935437564 @default.
- W3205379013 cites W1976406898 @default.
- W3205379013 cites W1987027605 @default.
- W3205379013 cites W2000686310 @default.
- W3205379013 cites W2007505836 @default.
- W3205379013 cites W2008410413 @default.
- W3205379013 cites W2009776996 @default.
- W3205379013 cites W2019550402 @default.
- W3205379013 cites W2025071373 @default.
- W3205379013 cites W2025483501 @default.
- W3205379013 cites W2027255721 @default.
- W3205379013 cites W2029030011 @default.
- W3205379013 cites W2035667407 @default.
- W3205379013 cites W2065326187 @default.
- W3205379013 cites W2066332959 @default.
- W3205379013 cites W2069501059 @default.
- W3205379013 cites W2071804506 @default.
- W3205379013 cites W2081495506 @default.
- W3205379013 cites W2085951097 @default.
- W3205379013 cites W2087962053 @default.
- W3205379013 cites W2088940658 @default.
- W3205379013 cites W2089198803 @default.
- W3205379013 cites W2093158584 @default.
- W3205379013 cites W2101964276 @default.
- W3205379013 cites W2103059305 @default.
- W3205379013 cites W2113980731 @default.
- W3205379013 cites W2121161073 @default.
- W3205379013 cites W2121305410 @default.
- W3205379013 cites W2124571763 @default.
- W3205379013 cites W2125049701 @default.
- W3205379013 cites W2125355462 @default.
- W3205379013 cites W2128852331 @default.
- W3205379013 cites W2130068692 @default.
- W3205379013 cites W2144024988 @default.
- W3205379013 cites W2145502099 @default.
- W3205379013 cites W2148824946 @default.
- W3205379013 cites W2153500348 @default.
- W3205379013 cites W2154874198 @default.
- W3205379013 cites W2165286872 @default.
- W3205379013 cites W2169392626 @default.
- W3205379013 cites W2255242978 @default.
- W3205379013 cites W2325596649 @default.
- W3205379013 cites W2345328813 @default.
- W3205379013 cites W2361659253 @default.
- W3205379013 cites W2427010553 @default.
- W3205379013 cites W2474079873 @default.
- W3205379013 cites W2490099107 @default.
- W3205379013 cites W2524852194 @default.
- W3205379013 cites W2524941869 @default.
- W3205379013 cites W2579217144 @default.
- W3205379013 cites W2617212687 @default.
- W3205379013 cites W2621232571 @default.
- W3205379013 cites W2743837016 @default.
- W3205379013 cites W2762801938 @default.
- W3205379013 cites W2794474032 @default.
- W3205379013 cites W2800941955 @default.
- W3205379013 cites W2802521793 @default.
- W3205379013 cites W2803476128 @default.
- W3205379013 cites W2903107073 @default.
- W3205379013 cites W2908320623 @default.
- W3205379013 cites W2922212539 @default.
- W3205379013 cites W2939897467 @default.
- W3205379013 cites W2950572741 @default.
- W3205379013 cites W2951890467 @default.
- W3205379013 cites W3010910558 @default.
- W3205379013 cites W3013791354 @default.
- W3205379013 cites W3030834164 @default.
- W3205379013 cites W3090750095 @default.
- W3205379013 cites W3095478621 @default.
- W3205379013 cites W3132196499 @default.
- W3205379013 cites W3185665707 @default.
- W3205379013 cites W3205379013 @default.
- W3205379013 doi "https://doi.org/10.1096/fj.202101105r" @default.
- W3205379013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34665898" @default.