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- W3205379617 abstract "Chemodynamic therapy (CDT) catalyzed by transition metal and starvation therapy catalyzed by intracellular metabolite oxidases are both classic tumor treatments based on nanocatalysts. CDT monotherapy has limitations including low catalytic efficiency of metal ions and insufficient endogenous hydrogen peroxide (H2O2). Also, single starvation therapy shows limited ability on resisting tumors. The metal-oxidase cascade catalytic system is to introduce intracellular metabolite oxidases into the metal-based nanoplatform, which perfectly solves the shortcomings of the above-mentioned monotherapiesIn this system, oxidases can not only consume tumor nutrients to produce a starvation effect, but also provide CDT with sufficient H2O2 and a suitable acidic environment, which further promote synergy between CDT and starvation therapy, leading to enhanced antitumor effects. More importantly, the metal-oxidase system can be combined with other antitumor therapies (such as photothermal therapy, hypoxia-activated drug therapy, chemotherapy, and immunotherapy) to maximize their antitumor effects. In addition, both metal-based nanoparticles and oxidases can activate tumor immunity through multiple pathways, so the combination of the metal-oxidase system with immunotherapy has a powerful synergistic effect. This article firstly introduced the metals which induce CDT and the oxidases which induce starvation therapy and then described the metal-oxidase cascade catalytic system in detail. Moreover, we highlight the application of the metal-oxidase system in combination with numerous antitumor therapies, especially in combination with immunotherapy, expecting to provide new ideas for tumor treatment." @default.
- W3205379617 created "2021-10-25" @default.
- W3205379617 creator A5007692427 @default.
- W3205379617 creator A5009232538 @default.
- W3205379617 creator A5033030336 @default.
- W3205379617 creator A5072562230 @default.
- W3205379617 creator A5074811571 @default.
- W3205379617 creator A5076426489 @default.
- W3205379617 creator A5084772683 @default.
- W3205379617 date "2021-10-16" @default.
- W3205379617 modified "2023-10-16" @default.
- W3205379617 title "Fenton/Fenton-like metal-based nanomaterials combine with oxidase for synergistic tumor therapy" @default.
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