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- W3205395616 abstract "We are pleased that the journal club chose to discuss our article and are indebted to the letter writers for their thoughtful questions. Our responses are as follows. First, the nomenclature we used for major vs minor adverse events (AEs) is standard. Major AEs require a return to the operating room and minor AEs do not. Second, there is no clear reason to suspect that children who cannot cooperate for specular microscopy have a greater rate of endothelial cell loss than those who can. Third, we agree that specular microscopy is important in longer-term follow-up. But, given that the rate of endothelial cell loss was low comparatively, returning uncooperative children to the operating room for specular microscopy under general anesthesia would be difficult to justify. Fourth, for extreme (pathologic) myopia, age and refractive error correlate poorly. Many preschool children in our cohort had magnitudes of myopia exceeding that of adolescents. Fifth, there was no discernable relationship between refractive error and pupillary block (or anterior chamber depth or axial length) in the few patients with this AE. Sixth, the correct number of children implanted bilaterally was 62 and unilaterally 36 (160 eyes). Seventh, we did propose a randomized, prospective clinical trial to further assess benefits and risks. The review panel of the National Eye Institute declined to fund the study. Their reason: The nonrandomized studies published to date demonstrate that benefits (average gains in visual acuity of a log unit) substantially outweigh risks (a minor rate of AE)." @default.
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- W3205395616 date "2021-12-01" @default.
- W3205395616 modified "2023-10-14" @default.
- W3205395616 title "Reply: Safety of phakic intraocular collamer lens implantation in 95 highly myopic special-needs children" @default.
- W3205395616 doi "https://doi.org/10.1097/j.jcrs.0000000000000851" @default.
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