Matches in SemOpenAlex for { <https://semopenalex.org/work/W3205430247> ?p ?o ?g. }
- W3205430247 abstract "Acute Kidney Injury (AKI) is an independent risk factor for mortality in hospitalized patients. AKI syndrome leads to fluid overload, electrolyte and acid-base disturbances, immunoparalysis, and propagates multiple organ dysfunction through organ crosstalk. Preclinical models suggest AKI causes acute lung injury (ALI), and conversely, mechanical ventilation and ALI cause AKI. In the clinical setting, respiratory complications are a key driver of increased mortality in patients with AKI, highlighting the bidirectional relationship. This article highlights the challenging and complex interactions between the lung and kidney in critically ill patients with AKI and acute respiratory distress syndrome (ARDS) and global implications of AKI. We discuss disease-specific molecular mediators and inflammatory pathways involved in organ crosstalk in the AKI-ARDS construct, and highlight the reciprocal hemodynamic effects of elevated pulmonary vascular resistance and central venous pressure (CVP) leading to renal hypoperfusion and pulmonary edema associated with fluid overload and increased right ventricular afterload. Finally, we discuss the notion of different ARDS phenotypes and the response to fluid overload, suggesting differential organ crosstalk in specific pathological states. While the directionality of effect remains challenging to distinguish at the bedside due to lag in diagnosis with conventional renal function markers and lack of tangible damage markers, this review provides a paradigm for understanding kidney-lung interactions in the critically ill patient." @default.
- W3205430247 created "2021-10-25" @default.
- W3205430247 creator A5022860583 @default.
- W3205430247 creator A5041950377 @default.
- W3205430247 creator A5042538381 @default.
- W3205430247 creator A5051567393 @default.
- W3205430247 creator A5058478191 @default.
- W3205430247 creator A5088942765 @default.
- W3205430247 date "2021-10-18" @default.
- W3205430247 modified "2023-10-01" @default.
- W3205430247 title "Two to Tango: Kidney-Lung Interaction in Acute Kidney Injury and Acute Respiratory Distress Syndrome" @default.
- W3205430247 cites W1537144565 @default.
- W3205430247 cites W1953282120 @default.
- W3205430247 cites W1955184950 @default.
- W3205430247 cites W1965033316 @default.
- W3205430247 cites W1968104658 @default.
- W3205430247 cites W1982613382 @default.
- W3205430247 cites W1986240011 @default.
- W3205430247 cites W1989710628 @default.
- W3205430247 cites W1992644453 @default.
- W3205430247 cites W1993985512 @default.
- W3205430247 cites W1996784183 @default.
- W3205430247 cites W1998765886 @default.
- W3205430247 cites W2008455196 @default.
- W3205430247 cites W2011112825 @default.
- W3205430247 cites W2014870509 @default.
- W3205430247 cites W2024224130 @default.
- W3205430247 cites W2030177843 @default.
- W3205430247 cites W2031776344 @default.
- W3205430247 cites W2034546193 @default.
- W3205430247 cites W2036823815 @default.
- W3205430247 cites W2040380840 @default.
- W3205430247 cites W2043671295 @default.
- W3205430247 cites W2049720707 @default.
- W3205430247 cites W2051180106 @default.
- W3205430247 cites W2051338691 @default.
- W3205430247 cites W2057687163 @default.
- W3205430247 cites W2060017302 @default.
- W3205430247 cites W2061628196 @default.
- W3205430247 cites W2074801801 @default.
- W3205430247 cites W2077726738 @default.
- W3205430247 cites W2081500137 @default.
- W3205430247 cites W2083175765 @default.
- W3205430247 cites W2083376892 @default.
- W3205430247 cites W2097665403 @default.
- W3205430247 cites W2107616906 @default.
- W3205430247 cites W2109492521 @default.
- W3205430247 cites W2110023205 @default.
- W3205430247 cites W2110720586 @default.
- W3205430247 cites W2114360920 @default.
- W3205430247 cites W2115672224 @default.
- W3205430247 cites W2116412377 @default.
- W3205430247 cites W2120048138 @default.
- W3205430247 cites W2123698136 @default.
- W3205430247 cites W2124451420 @default.
- W3205430247 cites W2124519382 @default.
- W3205430247 cites W2127991910 @default.
- W3205430247 cites W2133809160 @default.
- W3205430247 cites W2133904980 @default.
- W3205430247 cites W2135154890 @default.
- W3205430247 cites W2138698968 @default.
- W3205430247 cites W2143530377 @default.
- W3205430247 cites W2150737557 @default.
- W3205430247 cites W2152963006 @default.
- W3205430247 cites W2157225099 @default.
- W3205430247 cites W2163053457 @default.
- W3205430247 cites W2164965999 @default.
- W3205430247 cites W2165628507 @default.
- W3205430247 cites W2175574290 @default.
- W3205430247 cites W2210192368 @default.
- W3205430247 cites W2283083267 @default.
- W3205430247 cites W2314787815 @default.
- W3205430247 cites W2317492785 @default.
- W3205430247 cites W2322016253 @default.
- W3205430247 cites W2515625652 @default.
- W3205430247 cites W2550172802 @default.
- W3205430247 cites W2563335821 @default.
- W3205430247 cites W2570320605 @default.
- W3205430247 cites W2602915668 @default.
- W3205430247 cites W2605728799 @default.
- W3205430247 cites W2743806965 @default.
- W3205430247 cites W2772757612 @default.
- W3205430247 cites W2784785350 @default.
- W3205430247 cites W2788458080 @default.
- W3205430247 cites W2810427028 @default.
- W3205430247 cites W2883789215 @default.
- W3205430247 cites W2885500852 @default.
- W3205430247 cites W2891284285 @default.
- W3205430247 cites W2900765807 @default.
- W3205430247 cites W2907663273 @default.
- W3205430247 cites W2911440747 @default.
- W3205430247 cites W2912902612 @default.
- W3205430247 cites W2963362122 @default.
- W3205430247 cites W2970308898 @default.
- W3205430247 cites W2972970515 @default.
- W3205430247 cites W2994563255 @default.
- W3205430247 cites W3021791518 @default.
- W3205430247 cites W3036234613 @default.
- W3205430247 cites W3092778876 @default.
- W3205430247 cites W3128044416 @default.