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- W3205436253 abstract "Abstract We aimed to investigate whether antiresorptive agent drug holidays contributed to the formation of sequester separation and treatment outcome in medication-related osteonecrosis of the jaw (MRONJ) patients whose primary disease was malignancy. A total of 105 MRONJ patients with malignant tumors as the primary disease who underwent surgery at Nagasaki University Hospital and Kansai Medical University Hospital from January 2009 to December 2020 were included. We recorded patient age, sex, primary disease (solid cancer, non-solid cancer), MRONJ stage, type and administration period of antiresorptive agents, presence of diabetes, corticosteroid use, drug holiday period, white blood cell count, serum, albumin, serum creatinine, outcomes, and computed tomography findings. We examined the relationship between a drug holiday and sequester separation and outcome. Drug holiday of more than 90 days (P=0.629) was not a significant factor for sequester separation in the univariate analysis. In the multivariate analysis, steroid use (P=0.009) and serum albumin (P=0.003) were extracted as factors affecting prognosis; withdrawal for more than 90 days (P=0.98) was not a significant factor. MRONJ patients with cancer as the primary disease should be operated early without drug holidays if their general condition is relatively good, clinical symptoms are strong, and quality of life is improved." @default.
- W3205436253 created "2021-10-25" @default.
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- W3205436253 date "2021-10-13" @default.
- W3205436253 modified "2023-10-16" @default.
- W3205436253 title "Effects of Preoperative Drug Holiday On Sequester Separation and Treatment Outcome in Cancer Patients With Medication-Related Osteonecrosis of The Jaw" @default.
- W3205436253 doi "https://doi.org/10.21203/rs.3.rs-958449/v1" @default.
- W3205436253 hasPublicationYear "2021" @default.
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