FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3205436888> ?p ?o ?g. }

• W3205436888 endingPage "16" @default.
• W3205436888 startingPage "1" @default.
• W3205436888 abstract "The destruction of the low oxygen microenvironment in nucleus pulposus (NP) cells played a critical role in the pathogenesis of intervertebral disc degeneration (IVDD). The purpose of this study was to determine the potential role of integrin alpha 6 (ITG α6) in NP cells in response to high oxygen tension (HOT) in IVDD. Immunofluorescence staining and western blot analysis showed that the levels of ITG α6 expression were increased in the NP tissue from IVDD patients and the IVDD rat model with mild degeneration, which were reduced as the degree of degeneration increases in severity. In NP cells, the treatment of HOT resulted in upregulation of ITG α6 expression, which could be alleviated by blocking the PI3K/AKT signaling pathway. Further studies found that ITG α6 could protect NP cells against HOT-induced apoptosis and oxidative stress and protect NP cells from HOT-inhibited ECM protein synthesis. Upregulation of ITG α6 expression by HOT contributed to maintaining NP tissue homeostasis through the interaction with hypoxia-inducible factor-1α (HIF-1α). Furthermore, silencing of ITG α6 in vivo could obviously accelerate puncture-induced IVDD. Taken together, these results revealed that the increase of ITG α6 expression by HOT in NP cells might be a protective factor in IVD degeneration as well as restore NP cell function." @default.
• W3205436888 created "2021-10-25" @default.
• W3205436888 creator A5018717358 @default.
• W3205436888 creator A5021012194 @default.
• W3205436888 creator A5028317510 @default.
• W3205436888 creator A5030064573 @default.
• W3205436888 creator A5035059257 @default.
• W3205436888 creator A5042973046 @default.
• W3205436888 creator A5044464188 @default.
• W3205436888 creator A5050847096 @default.
• W3205436888 creator A5064510089 @default.
• W3205436888 creator A5074723866 @default.
• W3205436888 creator A5082025247 @default.
• W3205436888 date "2021-10-18" @default.
• W3205436888 modified "2023-10-17" @default.
• W3205436888 title "Increased Expression of Integrin Alpha 6 in Nucleus Pulposus Cells in Response to High Oxygen Tension Protects against Intervertebral Disc Degeneration" @default.
• W3205436888 cites W1552315430 @default.
• W3205436888 cites W1576773659 @default.
• W3205436888 cites W1651268213 @default.
• W3205436888 cites W1745281255 @default.
• W3205436888 cites W1894046416 @default.
• W3205436888 cites W1963772254 @default.
• W3205436888 cites W1966188170 @default.
• W3205436888 cites W1970734303 @default.
• W3205436888 cites W1977389886 @default.
• W3205436888 cites W1978877749 @default.
• W3205436888 cites W1979510017 @default.
• W3205436888 cites W1984500740 @default.
• W3205436888 cites W1995487944 @default.
• W3205436888 cites W2030460048 @default.
• W3205436888 cites W2035709886 @default.
• W3205436888 cites W2041997771 @default.
• W3205436888 cites W2049017382 @default.
• W3205436888 cites W2049985803 @default.
• W3205436888 cites W2107724393 @default.
• W3205436888 cites W2124078280 @default.
• W3205436888 cites W2124646082 @default.
• W3205436888 cites W2125208830 @default.
• W3205436888 cites W2134726909 @default.
• W3205436888 cites W2146617670 @default.
• W3205436888 cites W2154546982 @default.
• W3205436888 cites W2308789672 @default.
• W3205436888 cites W2512431324 @default.
• W3205436888 cites W2528626986 @default.
• W3205436888 cites W2765772050 @default.
• W3205436888 cites W2794421573 @default.
• W3205436888 cites W2804559184 @default.
• W3205436888 cites W2885551446 @default.
• W3205436888 cites W2926028701 @default.
• W3205436888 cites W2945973743 @default.
• W3205436888 cites W2952276039 @default.
• W3205436888 cites W2969504066 @default.
• W3205436888 cites W2989876701 @default.
• W3205436888 cites W3015099791 @default.
• W3205436888 cites W4213313767 @default.
• W3205436888 doi "https://doi.org/10.1155/2021/8632823" @default.
• W3205436888 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8545551" @default.
• W3205436888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34707783" @default.
• W3205436888 hasPublicationYear "2021" @default.
• W3205436888 type Work @default.
• W3205436888 sameAs 3205436888 @default.
• W3205436888 citedByCount "6" @default.
• W3205436888 countsByYear W32054368882022 @default.
• W3205436888 countsByYear W32054368882023 @default.
• W3205436888 crossrefType "journal-article" @default.
• W3205436888 hasAuthorship W3205436888A5018717358 @default.
• W3205436888 hasAuthorship W3205436888A5021012194 @default.
• W3205436888 hasAuthorship W3205436888A5028317510 @default.
• W3205436888 hasAuthorship W3205436888A5030064573 @default.
• W3205436888 hasAuthorship W3205436888A5035059257 @default.
• W3205436888 hasAuthorship W3205436888A5042973046 @default.
• W3205436888 hasAuthorship W3205436888A5044464188 @default.
• W3205436888 hasAuthorship W3205436888A5050847096 @default.
• W3205436888 hasAuthorship W3205436888A5064510089 @default.
• W3205436888 hasAuthorship W3205436888A5074723866 @default.
• W3205436888 hasAuthorship W3205436888A5082025247 @default.
• W3205436888 hasBestOaLocation W32054368881 @default.
• W3205436888 hasConcept C104317684 @default.
• W3205436888 hasConcept C127561419 @default.
• W3205436888 hasConcept C153911025 @default.
• W3205436888 hasConcept C178790620 @default.
• W3205436888 hasConcept C185592680 @default.
• W3205436888 hasConcept C190283241 @default.
• W3205436888 hasConcept C2776151105 @default.
• W3205436888 hasConcept C2776415932 @default.
• W3205436888 hasConcept C2993207723 @default.
• W3205436888 hasConcept C540031477 @default.
• W3205436888 hasConcept C55493867 @default.
• W3205436888 hasConcept C62478195 @default.
• W3205436888 hasConcept C75217442 @default.
• W3205436888 hasConcept C86803240 @default.
• W3205436888 hasConcept C95444343 @default.
• W3205436888 hasConceptScore W3205436888C104317684 @default.
• W3205436888 hasConceptScore W3205436888C127561419 @default.
• W3205436888 hasConceptScore W3205436888C153911025 @default.
• W3205436888 hasConceptScore W3205436888C178790620 @default.
• W3205436888 hasConceptScore W3205436888C185592680 @default.
• W3205436888 hasConceptScore W3205436888C190283241 @default.

• next