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- W3205445270 endingPage "5666" @default.
- W3205445270 startingPage "5647" @default.
- W3205445270 abstract "Continually emerging resistant strains of malarial parasites to current drugs present challenges. Understanding the underlying resistance mechanisms, especially those linked to allostery is, thus, highly crucial for drug design. This forms the main concern of the paper through a case study of falcipain 2 (FP-2) and its mutations, some of which are linked to artemisinin (ART) drug resistance. Here, we applied a variety of in silico approaches and tools that we developed recently, together with existing computational tools. This included novel essential dynamics and dynamic residue network (DRN) analysis algorithms. We identified six pockets demonstrating dynamic differences in the presence of some mutations. We observed striking allosteric effects in two mutant proteins. In the presence of M245I, a cryptic pocket was detected via a unique mechanism in which Pocket 2 fused with Pocket 6. In the presence of the A353T mutation, which is located at Pocket 2, the pocket became the most rigid among all protein systems analyzed. Pocket 6 was also highly stable in all cases, except in the presence of M245I mutation. The effect of ART linked mutations was more subtle, and the changes were at residue level. Importantly, we identified an allosteric communication path formed by four unique averaged BC hubs going from the mutated residue to the catalytic site and passing through the interface of three identified pockets. Collectively, we established and demonstrated that we have robust tools and a pipeline that can be applicable to the analysis of mutations." @default.
- W3205445270 created "2021-10-25" @default.
- W3205445270 creator A5004870074 @default.
- W3205445270 creator A5012149856 @default.
- W3205445270 creator A5013605617 @default.
- W3205445270 creator A5055672152 @default.
- W3205445270 creator A5088028251 @default.
- W3205445270 date "2021-01-01" @default.
- W3205445270 modified "2023-09-25" @default.
- W3205445270 title "Allosteric pockets and dynamic residue network hubs of falcipain 2 in mutations including those linked to artemisinin resistance" @default.
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