FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3205474328> ?p ?o ?g. }

• W3205474328 abstract "Smoking is known to be an added risk factor for tuberculosis (TB), with nearly a quarter of the TB cases attributed to cigarette smokers in the 22 countries with the highest TB burden. Many studies have indicated a link between risk of active TB and cigarette smoke. Smoking is also known to significantly decrease TB cure and treatment completion rate and increase mortality rates. Cigarette smoke contains thousands of volatile compounds including carcinogens, toxins, reactive solids, and oxidants in both particulate and gaseous phase. Yet, to date, limited studies have analyzed the impact of cigarette smoke components on Mycobacterium tuberculosis (Mtb), the causative agent of TB. Here we report the impact of cigarette smoke condensate (CSC) on survival, mutation frequency, and gene expression of Mtb in vitro. We show that exposure of virulent Mtb to cigarette smoke increases the mutation frequency of the pathogen and strongly induces the expression of the regulon controlled by SigH-a global transcriptional regulator of oxidative stress. SigH has previously been shown to be required for Mtb to respond to oxidative stress, survival, and granuloma formation in vivo. A high-SigH expression phenotype is known to be associated with greater virulence of Mtb. In patients with pulmonary TB who smoke, these changes may therefore play an important, yet unexplored, role in the treatment efficacy by potentially enhancing the virulence of tubercle bacilli." @default.
• W3205474328 created "2021-10-25" @default.
• W3205474328 creator A5025375015 @default.
• W3205474328 creator A5041209759 @default.
• W3205474328 creator A5064494874 @default.
• W3205474328 creator A5090964394 @default.
• W3205474328 date "2021-10-15" @default.
• W3205474328 modified "2023-09-24" @default.
• W3205474328 title "Transcriptional Response of Mycobacterium tuberculosis to Cigarette Smoke Condensate" @default.
• W3205474328 cites W1525242421 @default.
• W3205474328 cites W1549522998 @default.
• W3205474328 cites W1551684330 @default.
• W3205474328 cites W1894302566 @default.
• W3205474328 cites W1907919212 @default.
• W3205474328 cites W1921134765 @default.
• W3205474328 cites W1964566476 @default.
• W3205474328 cites W1964583664 @default.
• W3205474328 cites W1965455083 @default.
• W3205474328 cites W1974981032 @default.
• W3205474328 cites W1975401101 @default.
• W3205474328 cites W1987925634 @default.
• W3205474328 cites W1990505860 @default.
• W3205474328 cites W1992755900 @default.
• W3205474328 cites W1995354786 @default.
• W3205474328 cites W1995627495 @default.
• W3205474328 cites W1999294120 @default.
• W3205474328 cites W2000299318 @default.
• W3205474328 cites W2004247011 @default.
• W3205474328 cites W2005166795 @default.
• W3205474328 cites W2009857356 @default.
• W3205474328 cites W2011756735 @default.
• W3205474328 cites W2014892455 @default.
• W3205474328 cites W2014949552 @default.
• W3205474328 cites W2025742642 @default.
• W3205474328 cites W2028014530 @default.
• W3205474328 cites W2032930312 @default.
• W3205474328 cites W2033593008 @default.
• W3205474328 cites W2037878492 @default.
• W3205474328 cites W2044418926 @default.
• W3205474328 cites W2048351247 @default.
• W3205474328 cites W2049072333 @default.
• W3205474328 cites W2050154707 @default.
• W3205474328 cites W2056291500 @default.
• W3205474328 cites W2060726390 @default.
• W3205474328 cites W2062992777 @default.
• W3205474328 cites W2069764897 @default.
• W3205474328 cites W2070152071 @default.
• W3205474328 cites W2070424325 @default.
• W3205474328 cites W2070934613 @default.
• W3205474328 cites W2077088025 @default.
• W3205474328 cites W2079534946 @default.
• W3205474328 cites W2081138250 @default.
• W3205474328 cites W2085519327 @default.
• W3205474328 cites W2088731192 @default.
• W3205474328 cites W2091300474 @default.
• W3205474328 cites W2091405739 @default.
• W3205474328 cites W2091586024 @default.
• W3205474328 cites W2092469334 @default.
• W3205474328 cites W2096606273 @default.
• W3205474328 cites W2097883560 @default.
• W3205474328 cites W2098286274 @default.
• W3205474328 cites W2100235293 @default.
• W3205474328 cites W2101534380 @default.
• W3205474328 cites W2101830136 @default.
• W3205474328 cites W2106232644 @default.
• W3205474328 cites W2107292110 @default.
• W3205474328 cites W2111159572 @default.
• W3205474328 cites W2116799869 @default.
• W3205474328 cites W2117027913 @default.
• W3205474328 cites W2121823715 @default.
• W3205474328 cites W2123084649 @default.
• W3205474328 cites W2123624778 @default.
• W3205474328 cites W2123786680 @default.
• W3205474328 cites W2127974176 @default.
• W3205474328 cites W2130121916 @default.
• W3205474328 cites W2131129064 @default.
• W3205474328 cites W2137386776 @default.
• W3205474328 cites W2142136274 @default.
• W3205474328 cites W2143718468 @default.
• W3205474328 cites W2145007277 @default.
• W3205474328 cites W2146398753 @default.
• W3205474328 cites W2150600032 @default.
• W3205474328 cites W2154496968 @default.
• W3205474328 cites W2157159615 @default.
• W3205474328 cites W2158555503 @default.
• W3205474328 cites W2163311612 @default.
• W3205474328 cites W2168152179 @default.
• W3205474328 cites W2170060803 @default.
• W3205474328 cites W2235792065 @default.
• W3205474328 cites W2269375097 @default.
• W3205474328 cites W2272418187 @default.
• W3205474328 cites W2315426949 @default.
• W3205474328 cites W2343364184 @default.
• W3205474328 cites W2414326239 @default.
• W3205474328 cites W2415503013 @default.
• W3205474328 cites W2462425717 @default.
• W3205474328 cites W2499650193 @default.
• W3205474328 cites W2510124546 @default.
• W3205474328 cites W2512465611 @default.
• W3205474328 cites W2522390632 @default.

• next