Matches in SemOpenAlex for { <https://semopenalex.org/work/W3205489630> ?p ?o ?g. }
- W3205489630 abstract "A drug delivery system based on mesoporous particles MCM-41 was post-synthetically modified by photo-sensitive ligand, methyl-(2E)-3-(4-(triethoxysilyl)-propoxyphenyl)-2-propenoate (CA) and the pores of MCM-41 particles were loaded with Naproxen sodium salt (NAP). The CA was used as a photoactive molecule that can undergo a reversible photo-dimerization by [2π + 2π] cycloaddition when irradiated with UV light of specific wavelengths. Thus, it has a function of gate-keeper that is responsible for opening/closing the pores and minimizing premature release of NAP. The physicochemical properties of the prepared system were studied by infrared spectroscopy (IR), nitrogen adsorption measurements, thermogravimetric analysis (TGA), scanning transmission electron microscopy (STEM) and energy dispersive X-ray spectroscopy (EDX). The mechanism of the opening/closing pores was confirmed by UV measurements. In vitro and in vivo drug release experiments and the concentration of released NAP was determined by UV spectroscopy and high-performance liquid chromatography (HPLC). In vivo drug release in the blood circulatory system of rats has demonstrated the effective photo-cleavage reaction of CA molecules after UV-light stimulation. The localization and morphological changes of the particles were studied in the blood and liver of rats at different time intervals. The particles in the blood have been shown to retain their original rod-like shape, and the particles in the liver have been hydrolysed, which has resulted in spherical shape with a reduced size." @default.
- W3205489630 created "2021-10-25" @default.
- W3205489630 creator A5015735274 @default.
- W3205489630 creator A5022316830 @default.
- W3205489630 creator A5022730775 @default.
- W3205489630 creator A5024725522 @default.
- W3205489630 creator A5054101068 @default.
- W3205489630 creator A5069711840 @default.
- W3205489630 creator A5070249916 @default.
- W3205489630 creator A5072164428 @default.
- W3205489630 creator A5087123682 @default.
- W3205489630 creator A5089757477 @default.
- W3205489630 creator A5089946547 @default.
- W3205489630 date "2021-10-12" @default.
- W3205489630 modified "2023-10-16" @default.
- W3205489630 title "In vivo study of light-driven naproxen release from gated mesoporous silica drug delivery system" @default.
- W3205489630 cites W1019028989 @default.
- W3205489630 cites W2024881308 @default.
- W3205489630 cites W2031217171 @default.
- W3205489630 cites W2036559515 @default.
- W3205489630 cites W2058559717 @default.
- W3205489630 cites W2063280109 @default.
- W3205489630 cites W2082990150 @default.
- W3205489630 cites W2111423624 @default.
- W3205489630 cites W2139699067 @default.
- W3205489630 cites W2160771041 @default.
- W3205489630 cites W2168528735 @default.
- W3205489630 cites W2168731521 @default.
- W3205489630 cites W2322744662 @default.
- W3205489630 cites W2543322000 @default.
- W3205489630 cites W2559836632 @default.
- W3205489630 cites W2605218434 @default.
- W3205489630 cites W2621290312 @default.
- W3205489630 cites W2739931821 @default.
- W3205489630 cites W2780719111 @default.
- W3205489630 cites W2786121344 @default.
- W3205489630 cites W2811049607 @default.
- W3205489630 cites W2884195964 @default.
- W3205489630 cites W2885835642 @default.
- W3205489630 cites W2889233911 @default.
- W3205489630 cites W2894811421 @default.
- W3205489630 cites W2898114337 @default.
- W3205489630 cites W2914817763 @default.
- W3205489630 cites W2937653330 @default.
- W3205489630 cites W2941493172 @default.
- W3205489630 cites W2971651667 @default.
- W3205489630 cites W2978548546 @default.
- W3205489630 cites W2996348084 @default.
- W3205489630 cites W3013356872 @default.
- W3205489630 cites W3020761754 @default.
- W3205489630 cites W3042912767 @default.
- W3205489630 cites W3109769703 @default.
- W3205489630 cites W3141062222 @default.
- W3205489630 cites W3156981526 @default.
- W3205489630 cites W3163920737 @default.
- W3205489630 cites W4252706901 @default.
- W3205489630 doi "https://doi.org/10.1038/s41598-021-99678-y" @default.
- W3205489630 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8511123" @default.
- W3205489630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34642409" @default.
- W3205489630 hasPublicationYear "2021" @default.
- W3205489630 type Work @default.
- W3205489630 sameAs 3205489630 @default.
- W3205489630 citedByCount "24" @default.
- W3205489630 countsByYear W32054896302022 @default.
- W3205489630 countsByYear W32054896302023 @default.
- W3205489630 crossrefType "journal-article" @default.
- W3205489630 hasAuthorship W3205489630A5015735274 @default.
- W3205489630 hasAuthorship W3205489630A5022316830 @default.
- W3205489630 hasAuthorship W3205489630A5022730775 @default.
- W3205489630 hasAuthorship W3205489630A5024725522 @default.
- W3205489630 hasAuthorship W3205489630A5054101068 @default.
- W3205489630 hasAuthorship W3205489630A5069711840 @default.
- W3205489630 hasAuthorship W3205489630A5070249916 @default.
- W3205489630 hasAuthorship W3205489630A5072164428 @default.
- W3205489630 hasAuthorship W3205489630A5087123682 @default.
- W3205489630 hasAuthorship W3205489630A5089757477 @default.
- W3205489630 hasAuthorship W3205489630A5089946547 @default.
- W3205489630 hasBestOaLocation W32054896301 @default.
- W3205489630 hasConcept C121332964 @default.
- W3205489630 hasConcept C13245373 @default.
- W3205489630 hasConcept C13965031 @default.
- W3205489630 hasConcept C142724271 @default.
- W3205489630 hasConcept C150903083 @default.
- W3205489630 hasConcept C153642686 @default.
- W3205489630 hasConcept C161790260 @default.
- W3205489630 hasConcept C178790620 @default.
- W3205489630 hasConcept C185592680 @default.
- W3205489630 hasConcept C192562407 @default.
- W3205489630 hasConcept C204787440 @default.
- W3205489630 hasConcept C207001950 @default.
- W3205489630 hasConcept C2777496208 @default.
- W3205489630 hasConcept C2778115740 @default.
- W3205489630 hasConcept C2779820397 @default.
- W3205489630 hasConcept C2909752691 @default.
- W3205489630 hasConcept C32891209 @default.
- W3205489630 hasConcept C43617362 @default.
- W3205489630 hasConcept C60100273 @default.
- W3205489630 hasConcept C62520636 @default.
- W3205489630 hasConcept C71924100 @default.
- W3205489630 hasConcept C82776694 @default.