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• W3205536813 abstract "Pathogen-induced sepsis represents the main cause of infection-related death, and is becoming a great threat to human health. In this study, we developed a pathogen infection-responsive and macrophage endoplasmic reticulum-targeting nanoplatform to alleviate sepsis. The nanoplatform is composed of large-pore mesoporous silica nanoparticles (MSNs) grafted by an endoplasmic reticulum-targeting peptide (ERP), and a pathogen infection-responsive cap (TPB) containing the reactive oxygen species (ROS)-cleavable boronobenzyl acid linker (TSPBA) and bovine serum albumin (BSA). The TPB-capped MSNs exhibited the capacity to highly load the antimicrobial peptide melittin (MEL), and to rapidly release the cargo triggered by H2O2 or the pathogen-macrophage interaction system. During the interaction between pathogenic C. albicans cells and macrophages, the MEL-loading nanoplatform MSNE+MEL+TPB strongly inhibited pathogen growth, survived macrophages, and suppressed endoplasmic reticulum stress and secretion of pro-inflammatory cytokines. In a systemic infection model, the nanoplatform efficiently protected the mice from death, prevented kidney dysfunction and alleviated sepsis symptoms. This study developed an efficient multifunctional nanoplatform for treatment of sepsis.Funding Information: This work was supported by National Natural Science Foundation of China (3217010793, 31870139), Natural Science Foundation of Tianjin (19JCZDJC33800), and Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project (TSBICIP-KJGG-006).Declaration of Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.Ethics Approval Statement: All animal experiments were approved by the Animal Care and Use Committee at Nankai University." @default.
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• W3205536813 date "2021-01-01" @default.
• W3205536813 modified "2023-10-06" @default.
• W3205536813 title "Pathogen Infection-Responsive Nanoplatform Targeting Macrophage Endoplasmic Reticulum for Alleviating Sepsis" @default.
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• W3205536813 doi "https://doi.org/10.2139/ssrn.3940189" @default.
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