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- W3205547140 abstract "We show evolutionarily conserved pairwise genetic linkage and clustering of majority of colon and lung cancer susceptibility QTLs in mice, rats and humans. The patterns of susceptibility or resistance to these two cancers in recombinant congenic mouse strains were concordant and the responsible susceptibility loci closely linked, in spite of completely different carcinogens and protocols used for induction of the two tumors. Most DUSP (Dual specificity phosphatase) genes are linked to these clusters. These data suggest that an important part of colon and lung cancer susceptibility is controlled by related and evolutionarily conserved processes." @default.
- W3205547140 created "2021-10-25" @default.
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- W3205547140 date "2021-10-14" @default.
- W3205547140 modified "2023-09-26" @default.
- W3205547140 title "Evolutionarily conserved clusters of colon with lung cancer susceptibility loci, linked with most DUSP phosphatase genes, may help to dissect mechanisms of cancer susceptibility" @default.
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- W3205547140 doi "https://doi.org/10.1101/2021.10.13.461047" @default.
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