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- W3205561180 abstract "Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive death of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies (LBs). Mutations in PD-related genes lead to neuronal pathogenesis through various mechanisms, with known examples including SNCA/α-synuclein (PAKR1), Parkin (PARK2), PINK1 (PARK6), DJ-1 (PARK7), and LRRK2 (PARK8). Molecular chaperones/co-chaperones are proteins that aid the folding of other proteins into a functionally active conformation. It has been demonstrated that chaperones/co-chaperones interact with PD-related proteins and regulate their function in PD. HSP70, HSP90 and small heat shock proteins can prevent neurodegeneration by regulating α-syn misfolding, oligomerization and aggregation. The function of chaperones is regulated by co-chaperones such as HSP110, HSP40, HOP, CHIP, and BAG family proteins. Parkin, PINK1 and DJ-1 are PD-related proteins which are associated with mitochondrial function. Molecular chaperones regulate mitochondrial function and protein homeostasis by interacting with these PD-related proteins. This review discusses critical molecular chaperones/co-chaperones and PD-related proteins which contribute to the pathogenesis of PD, hoping to provide new molecular targets for therapeutic interventions to thwart the disease progression instead of only bringing symptomatic relief. Moreover, appreciating the critical role of chaperones in PD can also help us screen efficient biomarkers to identify PD at an early stage." @default.
- W3205561180 created "2021-10-25" @default.
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- W3205561180 date "2021-12-01" @default.
- W3205561180 modified "2023-09-30" @default.
- W3205561180 title "Molecular chaperones and Parkinson's disease" @default.
- W3205561180 cites W1559661072 @default.
- W3205561180 cites W1573542929 @default.
- W3205561180 cites W1588992473 @default.
- W3205561180 cites W1965888147 @default.
- W3205561180 cites W1969362677 @default.
- W3205561180 cites W1971108880 @default.
- W3205561180 cites W1972121275 @default.
- W3205561180 cites W1974208595 @default.
- W3205561180 cites W1974927898 @default.
- W3205561180 cites W1976325983 @default.
- W3205561180 cites W1977224722 @default.
- W3205561180 cites W1977723295 @default.
- W3205561180 cites W1979591162 @default.
- W3205561180 cites W1980087135 @default.
- W3205561180 cites W1981017216 @default.
- W3205561180 cites W1987155530 @default.
- W3205561180 cites W1991231925 @default.
- W3205561180 cites W1992725065 @default.
- W3205561180 cites W1995191747 @default.
- W3205561180 cites W1997524825 @default.
- W3205561180 cites W2008748100 @default.
- W3205561180 cites W2013453206 @default.
- W3205561180 cites W2017040646 @default.
- W3205561180 cites W2019933368 @default.
- W3205561180 cites W2021976306 @default.
- W3205561180 cites W2024243591 @default.
- W3205561180 cites W2025493128 @default.
- W3205561180 cites W2026314272 @default.
- W3205561180 cites W2026875466 @default.
- W3205561180 cites W2028705478 @default.
- W3205561180 cites W2032817175 @default.
- W3205561180 cites W2034659679 @default.
- W3205561180 cites W2035989121 @default.
- W3205561180 cites W2036604732 @default.
- W3205561180 cites W2037156284 @default.
- W3205561180 cites W2037316279 @default.
- W3205561180 cites W2039425688 @default.
- W3205561180 cites W2040233624 @default.
- W3205561180 cites W2041660879 @default.
- W3205561180 cites W2045132404 @default.
- W3205561180 cites W2045257543 @default.
- W3205561180 cites W2046784631 @default.
- W3205561180 cites W2049016912 @default.
- W3205561180 cites W2049631853 @default.
- W3205561180 cites W2052004580 @default.
- W3205561180 cites W2052098570 @default.
- W3205561180 cites W2052885679 @default.
- W3205561180 cites W2056353837 @default.
- W3205561180 cites W2057358353 @default.
- W3205561180 cites W2057364502 @default.
- W3205561180 cites W2059524588 @default.
- W3205561180 cites W2059577301 @default.
- W3205561180 cites W2062454540 @default.
- W3205561180 cites W2064774245 @default.
- W3205561180 cites W2066552226 @default.
- W3205561180 cites W2067094102 @default.
- W3205561180 cites W2068262186 @default.
- W3205561180 cites W2070529078 @default.
- W3205561180 cites W2076287552 @default.
- W3205561180 cites W2076981817 @default.
- W3205561180 cites W2079139546 @default.
- W3205561180 cites W2081155723 @default.
- W3205561180 cites W2083081815 @default.
- W3205561180 cites W2087689873 @default.
- W3205561180 cites W2091586455 @default.
- W3205561180 cites W2091993153 @default.
- W3205561180 cites W2092548312 @default.
- W3205561180 cites W2096966529 @default.
- W3205561180 cites W2099146435 @default.
- W3205561180 cites W2104655584 @default.
- W3205561180 cites W2105249930 @default.
- W3205561180 cites W2106296270 @default.
- W3205561180 cites W2108705280 @default.
- W3205561180 cites W2110780830 @default.
- W3205561180 cites W2114835861 @default.
- W3205561180 cites W2115988944 @default.
- W3205561180 cites W2119375793 @default.
- W3205561180 cites W2125465720 @default.
- W3205561180 cites W2127020153 @default.
- W3205561180 cites W2132796720 @default.
- W3205561180 cites W2135446666 @default.
- W3205561180 cites W2136452399 @default.
- W3205561180 cites W2137417707 @default.
- W3205561180 cites W2137952321 @default.
- W3205561180 cites W2138070282 @default.