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• W3205585964 abstract "Microbial dysbiosis and microbiome-induced inflammation have emerged as important factors in oral squamous cell carcinoma (OSCC) tumorigenesis during the last two decades. However, the rare biosphere of the oral microbiome, including fungi, has been sparsely investigated. This study aimed to characterize the salivary mycobiome in a prospective Sudanese cohort of OSCC patients and to explore patterns of diversities associated with overall survival (OS).Unstimulated saliva samples (n = 72) were collected from patients diagnosed with OSCC (n = 59) and from non-OSCC control volunteers (n = 13). DNA was extracted using a combined enzymatic-mechanical extraction protocol. The salivary mycobiome was assessed using a next-generation sequencing (NGS)-based methodology by amplifying the ITS2 region. The impact of the abundance of different fungal genera on the survival of OSCC patients was analyzed using Kaplan-Meier and Cox regression survival analyses (SPPS).Sixteen genera were identified exclusively in the saliva of OSCC patients. Candida, Malassezia, Saccharomyces, Aspergillus, and Cyberlindnera were the most relatively abundant fungal genera in both groups and showed higher abundance in OSCC patients. Kaplan-Meier survival analysis showed higher salivary carriage of the Candida genus significantly associated with poor OS of OSCC patients (Breslow test: p = 0.043). In contrast, the higher salivary carriage of Malassezia showed a significant association with favorable OS in OSCC patients (Breslow test: p = 0.039). The Cox proportional hazards multiple regression model was applied to adjust the salivary carriage of both Candida and Malassezia according to age (p = 0.029) and identified the genus Malassezia as an independent predictor of OS (hazard ratio = 0.383, 95% CI = 0.16-0.93, p = 0.03).The fungal compositional patterns in saliva from OSCC patients were different from those of individuals without OSCC. The fungal genus Malassezia was identified as a putative prognostic biomarker and therapeutic target for OSCC." @default.
• W3205585964 created "2021-10-25" @default.
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• W3205585964 date "2021-10-12" @default.
• W3205585964 modified "2023-10-07" @default.
• W3205585964 title "Analysis of Salivary Mycobiome in a Cohort of Oral Squamous Cell Carcinoma Patients From Sudan Identifies Higher Salivary Carriage of Malassezia as an Independent and Favorable Predictor of Overall Survival" @default.
• W3205585964 cites W1700919928 @default.
• W3205585964 cites W1965582081 @default.
• W3205585964 cites W1973513164 @default.
• W3205585964 cites W1974616606 @default.
• W3205585964 cites W1988171160 @default.
• W3205585964 cites W1989428785 @default.
• W3205585964 cites W1991669423 @default.
• W3205585964 cites W1994512840 @default.
• W3205585964 cites W1998490921 @default.
• W3205585964 cites W2000542878 @default.
• W3205585964 cites W2002836781 @default.
• W3205585964 cites W2025019766 @default.
• W3205585964 cites W2029103323 @default.
• W3205585964 cites W2046118138 @default.
• W3205585964 cites W2055304249 @default.
• W3205585964 cites W2056279562 @default.
• W3205585964 cites W2060626876 @default.
• W3205585964 cites W2064146024 @default.
• W3205585964 cites W2069094714 @default.
• W3205585964 cites W2074150122 @default.
• W3205585964 cites W2074552431 @default.
• W3205585964 cites W2077088073 @default.
• W3205585964 cites W2095566926 @default.
• W3205585964 cites W2107472852 @default.
• W3205585964 cites W2111672063 @default.
• W3205585964 cites W2113925621 @default.
• W3205585964 cites W2121748291 @default.
• W3205585964 cites W2121774335 @default.
• W3205585964 cites W2123105952 @default.
• W3205585964 cites W2126164662 @default.
• W3205585964 cites W2128769815 @default.
• W3205585964 cites W2130145167 @default.
• W3205585964 cites W2133817086 @default.
• W3205585964 cites W2137698181 @default.
• W3205585964 cites W2140539745 @default.
• W3205585964 cites W2144329388 @default.
• W3205585964 cites W2144986029 @default.
• W3205585964 cites W2159527342 @default.
• W3205585964 cites W2159535059 @default.
• W3205585964 cites W2401404581 @default.
• W3205585964 cites W2422545212 @default.
• W3205585964 cites W2438154719 @default.
• W3205585964 cites W2506667604 @default.
• W3205585964 cites W2562278855 @default.
• W3205585964 cites W2579544737 @default.
• W3205585964 cites W2587374790 @default.
• W3205585964 cites W2604886469 @default.
• W3205585964 cites W2606604256 @default.
• W3205585964 cites W2608515760 @default.
• W3205585964 cites W2623108751 @default.
• W3205585964 cites W2735288596 @default.
• W3205585964 cites W2739154049 @default.
• W3205585964 cites W2761493261 @default.
• W3205585964 cites W2762408691 @default.
• W3205585964 cites W2765423081 @default.
• W3205585964 cites W2765747110 @default.
• W3205585964 cites W2767133886 @default.
• W3205585964 cites W2768123055 @default.
• W3205585964 cites W2775765333 @default.
• W3205585964 cites W2788873704 @default.
• W3205585964 cites W2792063834 @default.
• W3205585964 cites W2792371390 @default.
• W3205585964 cites W2801050647 @default.
• W3205585964 cites W2803137361 @default.
• W3205585964 cites W2803328907 @default.
• W3205585964 cites W2803361005 @default.
• W3205585964 cites W2886557383 @default.
• W3205585964 cites W2889841399 @default.
• W3205585964 cites W2890523726 @default.
• W3205585964 cites W2900030356 @default.
• W3205585964 cites W2900678021 @default.
• W3205585964 cites W2909107070 @default.
• W3205585964 cites W2914746576 @default.
• W3205585964 cites W2937753868 @default.
• W3205585964 cites W2945673209 @default.
• W3205585964 cites W2949939796 @default.
• W3205585964 cites W2952463830 @default.
• W3205585964 cites W2953116118 @default.
• W3205585964 cites W2963276645 @default.
• W3205585964 cites W2979146632 @default.

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